Fukuda Atsuo

2017 - 2020 ゲノム編集技術を用いた希少難治性神経発達障害の原因遺伝子変異ノックインマウスモデルの確立およびその解析による病態解明と新規治療薬探索

2015 - 2020 Modal shifts in cellular and network oscillations

2017 - 2019 Developmental disorder model based on fetal hypothalamic GABA-Cl system disturbances

2015 - 2019 Crosstalk mechanism between glial cell- nerve cells with the GABA/ glutamic acid in the sensory ganglia

2015 - 2018 Effects of general anesthetics on the regulatory mechanisms of neuronal development in the critical period

2014 - 2017 Analyses on the mechanisms underlying the perturbation of regulatory machinery of intrinsic cellular properties of neural progenitors by the suppressed level of maternally-derived taurine

2014 - 2017 Models for developmental disorder induced by interaction of maternal stress and fetal factors

2015 - 2017 難治性てんかん病態におけるグリア機能の解明と診療ガイドライン作成の研究

2014 - 2016 PV-positive GABA cells-Role of extracellular sugar chains in glial tripartite synapse

2013 - 2016 Regulation of developmental switiching of inhibitory circuits

2013 - 2016 Multimodal GABA systems responding to environmental stress

2014 - 2016 難治性てんかんを呈する希少疾患群の遺伝要因と分子病態の解明

2012 - 2015 The study of the trigeminal neuralgia occurrence mechanism which an aberrant joining between cells in the ganglion causes

2012 - 2014 Taurine abnormality may underlie developmental disorders via perturbation of multimodal GABA actions

2011 - 2013 Rewriting of postnatal cortical meso-neural circuits by GABA modal shift perturbation during neurogenesis and migration

2010 - 2012 Developmentaldisorder of fetal GABA system by maternal stress

2011 - 2011 Perturbation of developmental Cl^-homeodynamics may underlie fetal and neonatal brain disorders

2009 - 2011 The approach to a trigeminal neuralgia mechanism based on a local GABA system hypothesis

2009 - 2010 Developmental modal shift of fetal brain GABA-A receptor action induced by maternal taurine

2008 - 2010 Approach to trigeminal neuralgia etiology based on the active chloride homeostasis hypothesis

2008 - 2009 Post-translational modification of chloride transporter KCC2 in fetal cerebral cortex in vivo

2007 - 2009 Cl-homeodynamics and resulting GABA_A-receptor-mediated functional changes underlying the cortical developmental disorder induced by stress

2007 - 2008 Universality and diversity of extrasynaptic signals and sensing mechanisms in the developmental environment of the brain

2006 - 2007 Functional coordination of GABAA receptor, Cl- transporter and taurine during cerebro-cortical neural circuit formation

2006 - 2006 Physiological approach to elucidate the mechanism of the newly discovered pre-synaptic action of midazolam

2005 - 2006 Exhaustive detection and analysis of gene expression associated with radial migration and differentiation in developing neocortical neurons

2004 - 2006 Environmental influences on cortical development and plasticity via Cl^-homeostasis modulation

2005 - 2005 A new hypothesis for a mechanism of actions of general anesthetics focusing on pre- and post-synaptic intracellular Cl- concentrations

2005 - 2005 Roles of GABA and taurine in cell-to-cell crosstalk during network formation of cerebral cortex

2004 - 2005 Establishment of trigeminal neuralgia model and role of ATP receptor for neuropathic pain

2004 - 2005 Glial Cl- transporter regulates extracellular Cl- to control excitability of neural circuits

2004 - 2004 Roles of Cl- in intercellular crosstalk of tangential and radial migrations during cerebral corticogenesis

2003 - 2004 Cl^-homeostasis failure and abnormal cell migration by endocrine disruptor cause damage to nervous system

2002 - 2004 Molecular mechanism of abnormal Cl- homeostasis and resultant abnormal GABA actions in the human epileptogenic focal cortical dysplasia

2003 - 2003 Cross-talk between Cajal-Retzius cells and migrating crotical palte neurons during neocortical neural network formation

2002 - 2003 Analysis for the cycle variation of [Cl^-]_i in supraoptic chiasma nucreus neuron

2000 - 2003 An approach for anti-sense therapy based on the establishment of an animal model for the epileptogenic cortical malformations

2002 - 2002 Cross-talk between Cajal-Retzius cells and migrating crotical palte neurons during neocortical neural network formation

2001 - 2001 発達脳の神経回路形成過程における細胞移動とCl^-ホメオタシス

2000 - 2001 Circadian Variation of GABAergic Action in the Supracgiasmatic Nucleus Neurons.

2000 - 2000 発達脳の神経回路形成過程における細胞移動とCl^-ホメオスタシス

1999 - 2000 Study of the dynamics of the local neural circuit by using Cl- imaging technique and understanding of the system

1998 - 1999 Striatal vulnerability and functional repair by neural grafts

1997 - 1999 Development of Huntington's model animals and protection of the symptom by antisense strategy

1998 - 1998 Cl^-輸送体/ポンプ機能の発達とGABA作用の変化による大脳皮質神経回路の発達

1997 - 1998 Neuron-Glia Interaction and Neural Network Function Involved in Ischemic Brain Damage.

1997 - 1997 Roles of Cl- transporters in the specific function of the immature inhibitory neural transmission in the neocortex

1996 - 1997 Striatal vulnerability and function repair by neural grafts

1995 - 1996 Mechanisms of cell in following brain ischemia and reconstruction of disturbed function by neural graft

1995 - 1996 Membrane Properties, Sunaptic Currents, and Intracellular Ca Transients in Transplanted Neurons in the Model Rats of Diseases of the Central Nervous System

1994 - 1994 Mechanism for the recovery of the neural network function in the Parkinsonian model rats treated with transplantation of the fetal substantia nigral cells.