Job title：
Associate Professor
Other affiliations (1)：
Osaka University
Institute for Protein Research
Associate Professor
Research field (3)：
Bioorganic chemistry
, Biophysics
, Structural biochemistry
Research keywords (6)：
Peptide Chemistry
, Solid State NMR
, Membrane Protein
, Structural Biology
, Biophysics
, Protein Chemistry
Research theme for competitive and other funds (7)：
2021 - 2024 Mechanism of Notch receptor signaling and its dependency on lipids
2016 - 2019 Chemical synthesis of caveolin
2014 - 2018 Elucidation of substrate recognition mechanism of I-CLiP in the trans- and juxta-membrane regions
2014 - 2015 1回膜貫通型蛋白質を一方向でリポソーム上に存在させる技術の開発
2012 - 2015 受容体型チロシンキナーゼの半合成と構造機能解析
2007 - 2008 Function of the transmembrane-juxtamembrane region of receptor tyrosine kinase in its activity regulation
2003 - 2008 Development of a method for membrane protein synthesis based on ligation chemistry
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Papers (40)：
Takeshi Sato, Akira Shinohara. Characterizing interaction between the juxtamembrane region of the single transmembrane protein and membrane using chemically synthesized peptides. STAR Protocols. 2023. 4. 3. 102454-102454
Ryo Maeda, Hiroko Tamagaki-Asahina, Takeshi Sato, Masataka Yanagawa, Yasushi Sako. Threonine phosphorylation regulates the molecular assembly and signaling of EGFR in cooperation with membrane lipids. Journal of Cell Science. 2022. 135. 15
Yuki Takechi-Haraya, Takashi Ohgita, Mana Kotani, Hiroki Kono, Chihiro Saito, Hiroko Tamagaki-Asahina, Kazuchika Nishitsuji, Kenji Uchimura, Takeshi Sato, Ryuji Kawano, et al. Effect of hydrophobic moment on membrane interaction and cell penetration of apolipoprotein E-derived arginine-rich amphipathic α-helical peptides. Sci.Rep. 2022. 23. 12. 4959
Hanumanthu BD Prasada Rao, Takeshi Sato, Kiran Challa, Yurika Fujita, Miki Shinohara, Akira Shinohara. Phosphorylation of luminal region of the SUN-domain protein Mps3 promotes nuclear envelope localization during meiosis. eLife. 2021. 10
Hironobu Hojo, Toshiki Takei, Yuya Asahina, Nobuaki Okumura, Toshifumi Takao, Masatomo So, Isao Suetake, Takeshi Sato, Akihiro Kawamoto, Yoshio Hirabayashi. Total Synthesis and Structural Characterization of Caveolin-1. Angewandte Chemie International Edition. 2021. 60. 25. 13900-13905
K. Nakamura, T. Hara, H. Tamagaki, Y. Akai, T. Sato, T. Kawakami, T. Kurokawa, Y. Fujiwara, Y. Okamura, S. Aimoto. SYNTHETIC STUDY OF VOLTAGE-GATED PROTON CHANNEL (VSOP/Hv). BIOPOLYMERS. 2009. 92. 4. 367-367
T. Hara, A. Tainosho, T. Sato, K. Nakamura, T. Kawakami, H. Akutsu, S. Aimoto. CHEMICAL SYNTHESIS, ISOLATION AND ASSEMBLY OF C-SUBUNITS OF HUMAN FOF1-ATP SYNTHASE. BIOPOLYMERS. 2009. 92. 4. 342-342
UESUGI Tomoya, NAKAMURA Ken'ichiroh, SATO Takeshi, KAWAKAMI Toru, AIMOTO Saburo. Chemical Synthesis of the Extracellular Juxtamembrane-Transmembrane Region of the Thrombopoietin Receptor. 2008. 2007. 211-212
NAKAMURA Ken'ichiroh, UESUGI Tomoya, SATO Takeshi, KAWAKAMI Toru, AIMOTO Saburo. Peptide Thioester Synthesis Based on an N-S Acyl Shift Reaction. 2008. 2007. 41-42
Function of transmembrane-juxtammebrane region of EGFR
(Symposium in the 56th annual meeting of the Biophysical Society of Japan, “Regulation of the signal transduction in cell membrane via localization and clustering of receptors” 2018)
Signaling across the membrane by receptor tyrosine kinase
(International Seminar on Biophysics and Chemical Biology of Biomembrane and Lipid Bilayers 2017)
Synthetic peptide for structure and function of membrane protein
(IPR International Seminar 2016)
Research on structure and function of membrane protein using synthetic transmembrane peptides
(19th Korean Peptide Protein Symposium 2015)
Mechanism for signaling through the membrane in activation of receptor tyrosine kinase;
(Molecular Targets for Diseases and Structural Life Science, The 9th International Symposium of the Institute Network 2014)
