Rchr
J-GLOBAL ID：200901052326022550
Update date: Mar. 31, 2024
Goto Yuji
後 藤祐児 | Goto Yuji
Affiliation and department：
Job title：
Specially Appointed Researcher
Research field (4)：
Biophysics
, Structural biochemistry
, Nanobioscience
, Nanomaterials
Research keywords (2)：
蛋白質科学
, Protien Science
Research theme for competitive and other funds (51)：
- 2022 - 2026 Exploring the supersaturation-dependent protein science
- 2020 - 2024 新規リン代謝マーカー:ポリリン酸と腎臓病で増悪する感染症の関連
- 2021 - 2023 Polyphosphate-dependent protein aggregation and its biological significance
- 2017 - 2022 Mechanism and regulation of protein aggregation in complicated cellular systems
- 2016 - 2018 Understanding the mechanism of amyloid fibrillation of proteins
- 2016 - 2018 Supersaturation-limited Large-scale Phase Transition of Denatured Proteins
- 2015 - 2018 Mechanism and regulation of protein aggregation in complicated cellular systems
- 2015 - 2018 Development of next-generation wireless-electroless oscillator biosensors for diagnosis and drug development
- 2015 - 2017 Experimental verification of hidden amyloidogenicity of proteins
- 2015 - 2016 Study of biomarkers of Parkinson's disease by the amplification of amyloid fibrils in biological sample
- 2012 - 2015 Role of supersaturation in the formation of amyloid fibrils
- 2011 - 2015 NMR approach and prediction for the residual structures in the intrinsically disordered proteins
- 2010 - 2014 Molecular design of nylon oligomer degradation enzyme and its application to bioproduction
- 2008 - 2012 Mechanism of abnormal protein aggregation and the study of the repair enzyme.
- 2010 - 2011 アミロイド異常凝集体の形成機構と制御
- 2009 - 2011 Understanding the mechanism of amyloid fibrillation on the basis of single fibril and real-time observation
- 2009 - 2011 Study on Peptide Display on Liposome Membranes for Disaggregation of Amyloid Fibrils
- 2009 - 2010 アミロイド線維形成中間体の立体構造と揺らぎ
- 2008 - 2010 アミロイド線維の構造とダイナミクスに関する研究
- 2008 - 2009 Study on crystallization and polymorphism of amyloidgenic proteins on biomembranes
- 2006 - 2008 Molecular pathogenesis of dialysis-related amyloidosis-A fusion of the in vitro model and the animal model-
- 2003 - 2008 水と生体分子が織り成す生命現象の化学に関する研究の総括
- 2003 - 2007 蛋白質のアミロイド線維形成における水の役割
- 2003 - 2005 Development of Sensor System to Analyse and Diagnose the abnormality of Protein Conformation
- 2003 - 2004 アミロイド線維形成反応の蛋白質立体構造に基づく研究
- 2003 - 2003 β2ミクログロブリンのアミロイド線維と分子シャペロンαクリスタリンの相互作用に関する研究
- 2001 - 2003 Understanding the amyloid fibril formation of β2-microglobulin on the basis of protein conformation
- 2001 - 2003 至適温度の異なる類縁蛋白質のフォールディングと構造安定化の機構
- 2002 - 2002 アミロイド線維形成反応の蛋白質立体構造に基づく研究
- 2001 - 2001 蛋白質フォールディング研究の企画調査
- 1997 - 2001 Dynamic interaction between chaperone and its substrates
- 1999 - 2000 Role of α-β transition in the folding of proteins
- 1998 - 2000 Single molecular analysis of protein folding
- 1999 - アミロイド線維形成
- 1999 - Amyloid Fibril Formation
- 1997 - 1998 Folding Mechanism of beta-Lactogobulin
- 1995 - 1998 タンパク質立体構造の安定性・ダイナミックス・折れたたみ機構
- 1995 - 1996 Structure and function of beta2-glycoprotein I
- 1995 - 1996 Joint Study on the Mechanism of Protein Folding
- 1995 - 1995 分子シャペロンの認識する基質タンパク質の高次構造の研究
- 1994 - 1995 Structures and Formation Mechanisms of Folding Intermediates of Proteins
- 1994 - 1994 分子シャペロンが認識する標的蛋白質の高次構造の研究
- 1993 - 1994 Molten Globule State of Proteins-Conformation, Stability, and Its Physiological Role
- 1990 - 1992 Molten-Globule of Proteins and Its Physiological Role
- 1986 - 1988 Conformations of Isolated Fragments of Pancreatic Polypeptide
- 1983 - 蛋白質の構造と安定性
- 1983 - 蛋白質の構造形成反応機構
- 1983 - Conformation and Stability of Proteins
- 1983 - Mechanism of Protein Folding
- アミロイドーシスの分子機構
- Molecular mechanism of amyloidosis
Show all
Papers (448)：
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Kichitaro Nakajima, Tomoki Ota, Hajime Toda, Keiichi Yamaguchi, Yuji Goto, Hirotsugu Ogi. Surface Modification of Ultrasonic Cavitation by Surfactants Improves Detection Sensitivity of α-Synuclein Amyloid Seeds. ACS Chemical Neuroscience. 2024
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Suguru Yamamoto, Keiko Yamamoto, Yoshitoshi Hirao, Keiichi Yamaguchi, Kichitaro Nakajima, Mami Sato, Miho Kawachi, Mio Domon, Kei Goto, Kentaro Omori, et al. Mass spectrometry-based proteomic analysis of proteins adsorbed by hexadecyl-immobilized cellulose bead column for the treatment of dialysis-related amyloidosis. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. 2024. 1-11
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Yuji Goto, Kichitaro Nakajima, Suguru Yamamoto, Keiichi Yamaguchi. Supersaturation, a critical factor underlying proteostasis of amyloid fibril formation. Journal of molecular biology. 2024. 168475-168475
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Lianjie Zhou, Touko Hajiri, Kichitaro Nakajima, César Aguirre, Kensuke Ikenaka, Hideki Mochizuki, Keiichi Yamaguchi, Yuji Goto, Hirotsugu Ogi. Ultrastiff Amyloid-Fibril Network of α-Synuclein Formed by Surface Seeding Reaction Confirmed by Multichannel Electrodeless Quartz-Crystal-Microbalance Biosensor. ACS Sensors. 2023
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Chi Jing Choong, César Aguirre, Keita Kakuda, Goichi Beck, Hiroki Nakanishi, Yasuyoshi Kimura, Shuichi Shimma, Kei Nabekura, Makoto Hideshima, Junko Doi, et al. Phosphatidylinositol-3,4,5-trisphosphate interacts with alpha-synuclein and initiates its aggregation and formation of Parkinson’s disease-related fibril polymorphism. ACTA NEUROPATHOLOGICA. 2023. 145. 5. 573-595
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MISC (99)：
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柚佳祐, 山本直樹, 野地真広, 宗正智, 後藤祐児, 岩崎哲史, 岩崎哲史, 鍔木基成, 茶谷絵理. Multi-step conformational changes via intermediate states induced by cross-seeding of human and bovine insulin amyloid fibrils. 日本生化学会大会(Web). 2020. 93rd
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櫻井一正, 茶谷絵理, 後藤祐児. タンパク質に対する圧力研究の新展開-基本熱力学から,分子構造に基づく理解,アミロイド線維まで. 化学. 2020. 75. 11
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CHATANI ERI, 後藤 祐児. 分子夾雑のタンパク質物理化学:タンパク質凝集研究の進展とこれから. 現代化学. 2019. 578. 26-30
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田巻初, 宗正智, 川本晃大, 後藤祐児, 藤原敏道, 松木陽. β2-microglobulinアミロイド線維のex vivo立体構造解析. Abstracts. Annual Meeting of the NMR Society of Japan. 2019. 58th (CD-ROM)
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田巻初, 宗正智, 後藤祐児, 藤原敏道, 松木陽. 固体NMRによるβ2-microglobulinアミロイド線維の立体構造解析. Abstracts. Annual Meeting of the NMR Society of Japan. 2018. 57th
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Books (7)：
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タンパク質科学
化学同人 2005
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Protein Science
KAGAKUDOJIN 2005
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Molecular chaperones in the life cycle of proteins : Structure, function, and mode of action. (共著)
Marcel Dekker 1997
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(訳本)タンパク質のフォールディング原理・機構・応用(共著)
シュプリンガー・フェアラーク東京 1995
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Mechanism of protein folding
1995
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Works (1)：
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タンパク質の構造異常性の解析・診断システムの構築
2004 -
Education (4)：
- - 1982 Osaka University
- - 1982 Osaka University Graduate School, Division of Natural Science Biologieal Chemistry
- - 1977 Osaka University School of Science
- - 1977 Osaka University Faculty of Science
Professional career (2)：
Committee career (3)：
- 2003 - 生物物理学会 委員
- 日本蛋白質科学会 理事
- 生化学会 評議員
Awards (1)：
Association Membership(s) (4)：
日本蛋白質科学会
, Protein Society
, 生物物理学会
, 生化学会
