Rchr

J-GLOBAL ID：200901052331896967 Update date: Apr. 17, 2024

AOKI Kazuhiro

アオキカズヒロ | AOKI Kazuhiro

Affiliation and department：
Job title： Professor

Research field (1)： Oral medicine

Research keywords (4)： Research related to the connection between oral bacteria and systemic diseases , Development of surface coating materials for the prevention of plaque growth , non-invasive method of bone augmentation , Development of bone anabolic agents

Research theme for competitive and other funds (57)：

2017 - 現在口腔細菌と全身健康との関連研究
2017 - 現在プラーク忌避表面コート剤の開発
2009 - 現在非侵襲的な骨量増量方法の開発
2019 - 2023 Development of a revolutionary bone anabolic reagent by optimizing the RANKL reverse signaling to stimulate bone formation.
2019 - 2023 骨形成を促進するRANKL逆シグナルスイッチの最適化から新規骨形成促進薬開発へ

2019 - 2022 骨形成を促進するRANKL逆シグナルスイッチの最適化から新規骨形成促進薬開発へ

2018 - 2020 口腔内細菌の持続的血管内注入による発癌および血栓形成惹起モデル確立への挑戦

2017 - 2020 BMP-2遺伝子発現ベクターとRANKL結合ペプチドによる新規骨形成法の開発

2017 - 2020 副作用の少ない小児ステロイド性顎骨骨粗鬆症治療における骨吸収阻害薬の開発

2017 - 2019 The therapeutic applications of RANKL working as a bone-formation-stimulating receptor

2016 - 2019 Examination of bone regeneration in cleft palate using RANKL binding peptide

2016 - 2019 Relationship between physical activity and mandibular growth: morphometric analysis of human facial skeleton and experiment using a mouse voluntary climbing exercise model

2016 - 2019 Repairing of heamatopoietic niche in bone marrow after X-ray irradiation

2016 - 2019 Consideration of inhibitory effect for inflammatory bone resorption with Cathepsin K inhibitors and Parathormone.

2018 - 2019 口腔内細菌の持続的血管内注入による発癌および血栓形成惹起モデル確立への挑戦

2017 - 2019 BMP-2遺伝子発現ベクターとRANKL結合ペプチドによる新規骨形成法の開発

2016 - 2018 A new drug development for accelerating bone and/or cartilage formation by RANK-like peptide

2017 - 2018 骨形成を促進する受容体として働くRANKLの解析と治療への応用

2016 - 2018 カテプシンK阻害薬とPTH併用による炎症性骨吸収抑制効果の検討

2016 - 2018 放射線照射による骨髄内環境の損傷とマクロファージによる修復機構の解析

2014 - 2017 Evaluation of the effects of occlusal disharmony-induced stress on bone metabolism during growth period in mice

2016 - 2017 RANK様ペプチドによる新規骨・軟骨形成促進薬の創生

2013 - 2016 Development of a new drug candidate to stimulate bone formation by oligomerization of RANKL-binding peptides

2013 - 2016 New bone resrption inhibitor based on agonistic function for TNF type 2 receptor

2012 - 2015 Development of TNF-receptor Antagonists which have both Anti-inflammatory Action and Bone Formation Activity and Apply Them for the Treatment of Periodontal Diseases.

2013 - 2015 TNF2型受容体アゴニストによる新規骨吸収抑制薬の創生

2013 - 2015 RANKL結合ペプチドのオリゴマー化による新規骨形成促進剤の創生

2012 - 2014 Effects of beta-adrenergic receptor signaling on occlusal disharmony-induced osteoporosis.

2011 - 2014 Molecular mechanism by which the alternative NF-kB pathway regulates bone metabolism and bone regeneration

2012 - 2014 抗炎症、骨量増加作用を併せ持つTNF拮抗薬開発と歯周疾患への応用

2011 - 2013 Establishment of bone invasion model by oral cancer and effects of NF-kB inhibitor on bone invasion.

2011 - 2012 Development of a new anabolic peptide on bone by the identification

2008 - 2010 The molecular mechanisms by which NF-κB regulates osteoclastogenesis and its application for the treatment of periodontitis

2007 - 2009 Development of new therapeutic drugs for inflammatory bone destruction by the CIAM compound, a new TNF receptor antagonist.

2007 - 2008 Development of peptide-delivery system using nanogel carrier for the control release of the peptide as the inhibitor of bone resorption toward clinical applications

2007 - 2008 破骨細胞のRANKオルタネイティブ・シグナル伝達を修飾するペプチドの創成

2006 - 2008 Studies on the control mechanism of osteoclast differentiation by non-coding RNA

2005 - 2006 破骨細胞のRANK-TRAF6結合を阻害する新規機能ペプチドの創成

2005 - 2006 炎症性骨吸収抑制薬による骨形成促進作用の検討

2004 - 2006 Development of New Hybrid-type Drugs Targeted to the Mechanism of Bone Remodeling

2004 - 2005 The functional analysis of RANKL signaling in osteoclast for developing the agonist of SHP-1

2004 - 2005 Molecular and cell biological approach to promote the eruption of impacted teeth

2002 - 2004 Development of inhibitor for inflammatory bone resorption using neuropeptide vasoactive intestinal peptide

2002 - 2003 Development of therapeutic RANKL vaccination approach against inflammatory alveolar-bone-destruction

2002 - 2003 The development of a new drug TNFα antagonistic peptide that inhibits bone destruction by cancer cells

2001 - 2003 Search for the new target points of bisphosphonates in bone cells: Their inhibitory actions on bone resorption and the stimulatory actions on bone formation

2001 - 2002 The epoch-making drug development of the inhibitor blocking inflammatory bone destruction in alveolar bones.

2000 - 2001 A new approach for the development of the inhibitor on bone resorption: New drug development from the contact point between ligand and receptor.

1999 - 2001 Regulation of bone resorption in jaw by the drug administration. Analysis by the 3D-bone histomorphometry and by the measurement of bone mineral density.

1997 - 1998 DEVELOPMENT OF DRUG WHICH REGULATES BONE RESORPTION ACTIVITY IN OSTEOCLASTS VIA CYTOSKELTON AND SIGNAL TRANSDUCTION SYSTEM

1996 - 1996 低Ca食飼育ラット脛骨におけるサイトカインの発現時期に関する基礎的研究

抗酸化作用とPDE阻害作用を併せ持つ新規骨粗鬆症治療薬の開発に関する研究

成長期骨代謝に与える身体運動刺激と咀嚼刺激の相乗作用:血中ホルモン動態に着目して

根尖部ニッチにおけるセメント質形成微小環境の構築と歯根吸収予防・修復への臨床展開

NFーkBの非古典的経路による骨代謝機構の分子基盤の解明と骨再生への応用

副作用の少ない小児ステロイド性顎骨骨粗鬆症治療における骨吸収阻害薬の開発

抗炎症、骨量増加作用を併せ持つTNF拮抗薬開発と歯周疾患への応用

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Papers (166)：

Hirohashi Yuna, Kamijo Shingo, Khan Masud, Ikeda Masaomi, Oki Meiko, Matin Khairul, Rashed Fatma, Aoki Kazuhiro. Tetracycline, an Appropriate Reagent for Measuring Bone-Formation Activity in the Murine Model of the Streptococcus mutans-Induced Bone Loss. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY. 2021. 11. 714366
Gao Jing, Muroya Ryusuke, Huang Fei, Nagata Kengo, Shin Masashi, Nagano Ryoko, Tajiri Yudai, Fujii Shinsuke, Yamaza Takayoshi, Aoki Kazuhiro, et al. Bone morphogenetic protein induces bone invasion of melanoma by epithelial-mesenchymal transition via the Smad1/5 signaling pathway. LABORATORY INVESTIGATION. 2021. 101. 1475-1483
Rashed Fatma, Kamijyo Shingo, Shimizu Yuri, Hirohashi Yuna, Khan Masud, Sugamori Yasutaka, Murali Ramachandran, Aoki Kazuhiro. The Effects of Receptor Activator of NF-kappa B Ligand-Binding Peptides on Bone Resorption and Bone Formation. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2021. 9. 648084
Okawara H, Arai Y, Matsuno H, Marcián P, Borák L, Aoki K, Wakabayashi N. Effect of load-induced local mechanical strain on peri-implant bone cell activity related to bone resorption and formation in mice: An analysis of histology and strain distributions. Journal of the mechanical behavior of biomedical materials. 2021. 116. 104370
天野均, 大庭伸介, 青木和広. ヘリオキサンチン誘導体による破骨細胞分化誘導系に及ぼす影響に関する研究. 日本骨代謝学会学術集会プログラム抄録集. 2020. 38回. 126-126

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MISC (73)：

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Patents (3)：

オステオプロテジェリン誘導体及びその用途(青木和広、加藤玄樹、大谷啓一)
新規な架橋構造を含むTNFレセプターループペプチドの模倣ペプチドを用いた医薬組成物
新規な架橋構造を含むTNFレセプターループペプチドの模倣ペプチドを用いた医薬組成物.

Books (17)：

現代歯科薬理学第6版 4刷改訂
医歯薬出版 2021
Beclin1 は,破骨細胞および軟骨細胞の分化の制御により骨恒常性を調節する
JBMR日本語版vol 7 No.1 2020
特定の RANK 細胞内モチーフが破骨細胞形成を推進する
JBMR日本語版vol 7 No.1 2020
歯科衛生学辞典
永末書店 2019
「WAIF1 は骨吸収と骨形成をカップリングさせる細胞表面 CTHRC1 結合蛋白質である」
JBMR日本語版vol 5 No.3 2019

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Lectures and oral presentations (255)：

ヘリオキサンチン誘導体による破骨細胞分化誘導系に及ぼす影響に関する研究
(第38回日本骨代謝学会学術集会 2020)
石灰化組織評価の実践とネットワーキング骨形態計測法からシグナル伝達研究への発展
(第62回歯科基礎医学会学術大会骨形態計測学会・歯科基礎医学会合同シンポジウム 2020)
RANKL-RANK-OPGシグナル研究の最前線膜型RANKLを標的にした骨形成促進薬の開発
(第62回歯科基礎医学会学術大会アップデートシンポジウム 2020)
The peptide drug delivery for bone regeneration
(Cutting Edge of Bone and Mineral Research in 2019 2019)
The effects of RANKL-binding peptides on osteoblast differentiation
(The 42nd Annual Meeting of the Molecular Biology Society of Japan 2019)

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Education (2)：

- 1992 Tokyo Medical and Dental University Graduate School, Division of Dental Research Dental Pharmacology
- 1988 Tokyo Medical and Dental University Faculty of Dentistry Faculty of Dentistry

Professional career (1)：

Ph.D (Tokyo Medical and Dental University)

Work history (6)：

2017/02 - 現在 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Medical and Dental Science and Technology Basic Oral Health Engineering Professor
2009/04/01 - 2017/01/31 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Medical and Dental Sciences Bio-Matrix Pharmacology Associate Professor
2010/08/01 - 2012/07/31 Ministry of Education, Program officer
1995/04/01 - 2009/03/31 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Medical and Dental Sciences Bio-Matrix Pharmacology Assistant Professor
1997/10/01 - 1999/09/30 Yale University Faculty of Medicine Department of Cell Biology Postdoctoral fellow (Prof. Roland Baron's Lab)

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Committee career (11)：

2009 - 現在日本骨代謝学会評議員
2009 - 現在歯科基礎医学会評議員
2008 - 現在日本骨形態計測学会評議員
2018/05 - 2020/07 歯科基礎医学会理事
2009 - 2017 日本薬理学会学術評議員

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Awards (11)：

2019/11 - The 2nd International Oral Health Engineering Consortium (Taipei) The 2nd and 3rd prizes of the student competition at the 2nd Meeting of International Oral Health Engineering Consortium (Yosuke Sasaki, Yuna hirohashi)
2018/09 - The 2nd prize of the student competition at the 1st Meeting of International Oral Health Engineering Consortium (Ayaka Urakawa)
2018/09 - 第6回レーザー歯学会学術奨励賞 (三上理沙子)
2018/06 - 第38回日本骨形態計測学会若手研究者賞 (新井祐貴)
2016/08 - 第58回歯科基礎医学会学術大会モリタ賞(薬理部門)(上原智己) RANKL 結合ペプチド(OP3-4)の注射投与は,BMP-2 により誘導されるマウス上顎の骨造成を促進する

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