Rchr
J-GLOBAL ID：200901052479621533
Update date: Jan. 30, 2024
Tsukamoto Hirotake
ツカモト ヒロタケ | Tsukamoto Hirotake
Affiliation and department：
Job title：
Junior Associate Professor
Research field (1)：
Immunology
Research keywords (5)：
T細胞
, がん
, 老化
, 免疫
, Immunology aging cancer
Research theme for competitive and other funds (7)：
Papers (75)：
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Yusuke Tomita, Shinya Sakata, Kosuke Imamura, Shinji Iyama, Takayuki Jodai, Koichi Saruwatari, Shohei Hamada, Kimitaka Akaike, Moriyasu Anai, Kazuaki Fukusima, et al. Association of Clostridium butyricum Therapy Using the Live Bacterial Product CBM588 with the Survival of Patients with Lung Cancer Receiving Chemoimmunotherapy Combinations. Cancers. 2023. 16. 1. 47-47
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Yuji Miura, Takanobu Motoshima, Toshiki Anami, Hiromu Yano, Remi Mito, Cheng Pan, Shinji Urakami, Keiichi Kinowaki, Hirotake Tsukamoto, Ryoma Kurahashi, et al. Predictive value of CXCL10 for the occurrence of immune-related adverse events in patient with renal cell carcinoma. Microbiology and immunology. 2023
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Yoshihiro Komohara, Daisuke Kurotaki, Hirotake Tsukamoto, Yuko Miyasato, Hiromu Yano, Cheng Pan, Yutaka Yamamoto, Yukio Fujiwara. Involvement of protumor macrophages in breast cancer progression and characterization of macrophage phenotypes. Cancer science. 2023
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Takahiko Akiyama, Tadahito Yasuda, Tomoyuki Uchihara, Noriko Yasuda-Yoshihara, Benjy J Y Tan, Atsuko Yonemura, Takashi Semba, Juntaro Yamasaki, Yoshihiro Komohara, Koji Ohnishi, et al. Stromal reprogramming through dual PDGFRα/β blockade boosts the efficacy of anti-PD-1 immunotherapy in fibrotic tumors. Cancer research. 2022. 83. 5. 753-770
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Hirotake Tsukamoto, Yoshihiro Komohara, Yusuke Tomita, Yuji Miura, Takanobu Motoshima, Kosuke Imamura, Toshiki Kimura, Tokunori Ikeda, Yukio Fujiwara, Hiromu Yano, et al. Aging-associated and CD4 T-cell-dependent ectopic CXCL13 activation predisposes to anti-PD-1 therapy-induced adverse events. Proceedings of the National Academy of Sciences. 2022. 119. 29
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MISC (44)：
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菰原 義弘, 塚本 博丈. 【がん免疫療法の個別化を支える 新・腫瘍免疫学】第I部 腫瘍免疫応答の基本とその制御メカニズム (第1章)腫瘍免疫応答の正負の調節機構 がん免疫におけるマクロファージの役割 病態形成における存在意義と標的細胞としての可能性. 実験医学. 2019. 37. 15. 2443-2451
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塚本 博丈, 押海 裕之. 【がん免疫と免疫療法】IL-6とPD-1/PD-L1シグナルの併用阻害による免疫抑制効果の相互制御の遮断. 臨床免疫・アレルギー科. 2019. 72. 2. 165-173
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栗山 春香, 福島 聡, 木村 俊寛, 石橋 卓行, 門久 美菜, 久保 陽介, 中原 智史, 宮下 梓, 猪爪 隆史, 塚本 博丈, et al. 悪性黒色腫に対する4-1BBリガンド導入iPS細胞由来ミエロイドラインを用いた免疫療法. 日本がん免疫学会総会プログラム・抄録集. 2019. 23回. 110-110
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Yasuharu Nishimura, Koji Fujieda, Azusa Miyashita, Satoshi Fukushima, Tokunori Ikeda, Yosuke Kubo, Satoru Senju, Hironobu Ihn, Hiroyuki Oshiumi, Hirotake Tsukamoto. Combination of anti-IL-6 and anti-PD-L1 antibodies synergistically reinvigorates cancer immunity by activating both CTL and Th1 cells in mice. CANCER RESEARCH. 2019. 79. 13
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Hirotake Tsukamoto, Koji Fujieda, Azusa Miyashita, Satoshi Fukushima, Tokunori Ikeda, Yosuke Kubo, Satoru Senju, Hironobu Ihn, Yasuharu Nishimura, Hiroyuki Oshiumi. Combined blockade of IL-6 and PD-1/PD-L1 signals breaks mutual regulation of their immunosuppressive effects. CANCER SCIENCE. 2018. 109. 624-624
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Books (11)：
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Precision Medicine "Development of combined cancer immunotherapy based on age-associated immune dysfunction"
2020
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The role of macrophages in anti-tumor immune response
Yodosha 2019
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「IL-6とPD-1/PD-L1シグナルの併用阻害による免疫抑制効果の相互制御の遮断」 臨床免疫・アレルギー科
科学評論社 2019
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「免疫老化とがん免疫」 アンチ・エイジング医学
メディカルレビュー社 2017
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「IL-6と老年における免疫応答の低下」 臨床免疫・アレルギー科, 科学評論社
科学評論社 2016
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Lectures and oral presentations (14)：
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Exosomal miR192 regulates inflammatory response induced by Influenza whole vaccine
(2019)
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Targeting of age-associated increased in IL-6 improves the responsiveness to cancer immunotherapies in old age
(2019)
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Combined blockade of IL-6 and PD-1/PD-L1 signaling abrogates mutual regulation of their immunosuppressive effects in the tumor microenvironment
(2018)
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Combined blockade of IL-6 and PD-1/PD-L1 signals breaks mutual regulation of their immunosuppressive effects
(2018)
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Combined blockade of IL-6 and PD-1/PD-L1 signals breaks mutual regulation of their immunosuppressive effects in tumor
(2017)
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Works (4)：
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老齢個体のT細胞増殖不全と、それによるがん免疫療法効果低下におけるHippo経路の関与
2015 - 2017
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CD4+T細胞を介した抗腫瘍免疫応答に対する 可溶性IL-6受容体の影響の解析
2013 - 2014
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担癌固体でのCD4+T細胞機能不全の発生機序におけるミエロイド系抑制性細胞(MDSC)由来のIL-6の影響についての検討
2012 - 2013
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担癌個体におけるミエロイド系抑制性細胞によるT細胞機能不全の発生機序の解明
2010 - 2011
Education (3)：
- 2002 - 2006 Kumamoto University
- 2000 - 2002 Kumamoto University
- 1996 - 2000 Tottori University
Professional career (1)：
- Ph.D (Kumamoto University)
Work history (3)：
- 2016/04 - 2021/03 Graduate School of Medical Sciences, Kumamoto University Department of Immunology
- 2010 - Kumamoto University Faculty of Life Sciences
- 2010 - Assistant Professor,Faculty of Life Sciences(Basic medicine group),Kumamoto University
Committee career (1)：
Awards (4)：
- 2018/12 - Japanese Society of Immunology Best Presentation Award
- 2016/11 - Research Achievement Award
- 2013 - Young Investigator Award
- 2013 - Tadamitsu Kishimoto International Travel Award
Association Membership(s) (4)：
アメリカ免疫学会
, 日本がん免疫学会
, 免疫学会
, American Association of Immunologists
