Oshiumi Hiroyuki

オシウミヒロユキ | Oshiumi Hiroyuki

Affiliation and department：
Job title： Professor

Research field (2)： Virology , Immunology

Research keywords (5)：ウイルス , ワクチン , 感染症 , 免疫学 , Immunology

Research theme for competitive and other funds (13)：

2023 - 2026 代謝異常がウイルスに対する自然免疫を制御する新たなメカニズムの解明
2019 - 2022 Study of innate immune responses against viral infection
2017 - 2019 The role of novel molecules on innate immune respose.
2015 - 2018 Novel interaction between virus and host innate immune system
2012 - 2015 Novel molecular mechanisms of antiviral innate immune response

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Papers (130)：

Mako Yamaguchi, Yohana S. Mtali, Hitomi Sonokawa, Ken Takashima, Yoshimi Fukushima, Takahisa Kouwaki, Hiroyuki Oshiumi. HPV vaccines induce trained immunity and modulate pro-inflammatory cytokine expression in response to secondary Toll-like receptor stimulations. Microbiology and Immunology. 2023. 68. 2. 65-74
Yoshifumi Baba, Noriko Yasuda, Miki Bundo, Yutaka Nakachi, Junko Ueda, Takatsugu Ishimoto, Masaaki Iwatsuki, Yuji Miyamoto, Naoya Yoshida, Hiroyuki Oshiumi, et al. LINE-1 hypomethylation, increased retrotransposition and tumor-specific insertion in upper gastrointestinal cancer. Cancer Science. 2023. 115. 1. 247-256
Tetsuro Matsunaga, Hirohito Sano, Katsuya Takita, Masanobu Morita, Shun Yamanaka, Tomohiro Ichikawa, Tadahisa Numakura, Tomoaki Ida, Minkyung Jung, Seiryo Ogata, et al. Supersulphides provide airway protection in viral and chronic lung diseases. Nature communications. 2023. 14. 1. 4476-4476
Mako Toyoda, Toong Seng Tan, Chihiro Motozono, Godfrey Barabona, Akiko Yonekawa, Nobuyuki Shimono, Rumi Minami, Yoji Nagasaki, Yusuke Miyashita, Hiroyuki Oshiumi, et al. Evaluation of Neutralizing Activity against Omicron Subvariants in BA.5 Breakthrough Infection and Three-Dose Vaccination Using a Novel Chemiluminescence-Based, Virus-Mediated Cytopathic Assay. Microbiology spectrum. 2023. e0066023
Takahisa Kouwaki, Tasuku Nishimura, Guanming Wang, Reiko Nakagawa, Hiroyuki Oshiumi. K63-linked polyubiquitination of LGP2 by Riplet regulates RIG-I-dependent innate immune response. EMBO Reports. 2022. 24. 2. e54844

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MISC (36)：

藤岡周助, 岡香織, 河村佳見, 菰原義弘, 中條岳志, 山村祐紀, 大岩祐基, 須藤洋一, 小巻翔平, 大豆生田夏子, et al. ハダカデバネズミの炎症応答の減弱は発がん耐性に寄与している. 日本薬学会年会要旨集. 2021. 141年会. 29V08-am11S
高島謙, 押海裕之. The innate immune response to SARS-CoV-2. ウイルス. 2021. 71. 1
高島謙, 押海裕之. Regulation of immunoglobulin production in Golgi apparatus. 月刊臨床免疫・アレルギー科. 2021. 76. 6
塚本博丈, 押海裕之. 【がん免疫と免疫療法】IL-6とPD-1/PD-L1シグナルの併用阻害による免疫抑制効果の相互制御の遮断. 臨床免疫・アレルギー科. 2019. 72. 2. 165-173
Yasuharu Nishimura, Koji Fujieda, Azusa Miyashita, Satoshi Fukushima, Tokunori Ikeda, Yosuke Kubo, Satoru Senju, Hironobu Ihn, Hiroyuki Oshiumi, Hirotake Tsukamoto. Combination of anti-IL-6 and anti-PD-L1 antibodies synergistically reinvigorates cancer immunity by activating both CTL and Th1 cells in mice. CANCER RESEARCH. 2019. 79. 13

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Lectures and oral presentations (12)：

ウイルス感染に対する自然免疫応答とコレステロール
(日本肺サーファクタント・界面医学会第 59 回学術研究会 2023)
Unusual type I interferons are associated with cholesterol metabolism and prime the antiviral innate immune response
(2023)
Innate and adaptive immune responses to SARS-CoV-2 infection
(2021)
mRNAワクチンの機序と新型コロナワクチンの展望
(熊本県医療人育成総合会議 2021)
細胞内ウイルスRNAセンサーの翻訳後修飾による自然免疫応答の制御
(日本生体防御学会学術総会 2021)

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Education (3)：

1998 - 2001 Osaka University Graduate School of Science
1996 - 1998 大阪大学大学院理学研究科生物科学専攻博士前期課程
1992 - 1996 Osaka University School of Science

Professional career (1)：

博士(理学) (大阪大学)

Work history (7)：

2014/12 - 2015/11 北海道大学人獣共通感染症リサーチセンター
2015 - Kumamoto University Faculty of Life Sciences
2015 - Professor,Faculty of Life Sciences(Basic medicine group),Kumamoto University
2005/12 - 2014/11 北海道大学大学院医学研究科免疫学分野助教・講師
2004/02 - 2005/11 Osaka University

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