MIKA KIKKAWA

Homepage URL (1)： http://www.juntendo.ac.jp/graduate/laboratory/labo/seitai_bunshi/index.html

Research field (2)： Medical biochemistry , Genetics

Research keywords (6)：パスウェイ解析 , プロテオーム解析 , イメージング一般 , 発現解析 , DNAマイクロアレイ , DNA microarray

Research theme for competitive and other funds (7)：

2012 - 2015 Study on the germline FLCN mutations and the mechanism of pulmonary cyst formation in Birt-Hogg-Dube syndrome
2010 - 2012 Birt-Hogg-Dube症候群の網羅的遺伝子診断と肺嚢胞形成機序解明の試み
2008 - Birt-Hogg-Dube症候群の新規遺伝子診断法の確立と肺嚢胞形成機序の解明
2008 - Elucidation of lung cysts formation mechanism and establish of new genetic diagnosis for Birt-Hogg-Dubé syndrome
DNAマイクロアレイによるオートファジー関連遺伝子ノックアウトマウスの網羅的遺伝子発現解析

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Papers (16)：

Yoshihito Nihei, Kei Haniuda, Mizuki Higashiyama, Shohei Asami, Hiroyuki Iwasaki, Yusuke Fukao, Maiko Nakayama, Hitoshi Suzuki, Mika Kikkawa, Saiko Kazuno, et al. Identification of IgA autoantibodies targeting mesangial cells redefines the pathogenesis of IgA nephropathy. Science advances. 2023. 9. 12. eadd6734
Shun-suke Sakai, Atsushi Hasegawa, Ryosuke Ishimura, Naoki Tamura, Shun Kageyama, Satoko Komatsu-Hirota, Manabu Abe, Yiwei Ling, Shujiro Okuda, Manabu Funayama, et al. Loss of Atg2b and Gskip Impairs the Maintenance of the Hematopoietic Stem Cell Pool Size. Molecular and Cellular Biology. 2022. 42. 1
Yoko Tabe, Kaori Saitoh, Haeun Yang, Kazumasa Sekihara, Kotoko Yamatani, Vivian Ruvolo, Hikari Taka, Naoko Kaga, Mika Kikkawa, Hajime Arai, et al. Inhibition of FAO in AML co-cultured with BM adipocytes: mechanisms of survival and chemosensitization to cytarabine. Scientific Reports. 2018. 8. 1
Kazumasa Sekihara, Kaori Saitoh, Haeun Yang, Haruki Kawashima, Saiko Kazuno, Mika Kikkawa, Hajime Arai, Takashi Miida, Nobuhiro Hayashi, Francois Niyonsaba, et al. Correction: Low-dose ionizing radiation exposure represses the cell cycle and protein synthesis pathways in in vitro human primary keratinocytes and U937 cell lines. PLOS ONE. 2018. 13. 10. e0205581-e0205581
Kazumasa Sekihara, Kaori Saitoh, Haeun Yang, Haruki Kawashima, Saiko Kazuno, Mika Kikkawa, Hajime Arai, Takashi Miida, Nobuhiro Hayashi, Keisuke Sasai, et al. Low-dose ionizing radiation exposure represses the cell cycle and protein synthesis pathways in in vitro human primary keratinocytes and U937 cell lines. PLOS ONE. 2018. 13. 6. e0199117-e0199117

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MISC (34)：

K. Sekihara, S. Yamamoto, M. Kikkawa, H. Taka, N. Kaga, H. Matsushita, H. Hayashi, M. Tanaka, T. Miida, M. Andreeff, et al. The mTOR kinase inhibitor AZD-2014 enhances the antitumor effects of XPO1 antagonist KPT-185 in mantle cell lymphoma. ANNALS OF ONCOLOGY. 2015. 26. 39-39
瀬山邦明, 熊坂利夫, 林大久生, 三谷恵子, 片岡秀之, 吉川美加, 飛野和則, 小林悦子, 郡司陽子, 久能木真喜子, et al. 呼吸不全に関する調査研究 Birt-Hogg-Dube症候群の肺嚢胞の特徴に関する研究 50例の患者からの229個の肺嚢胞の病理組織学的および形態計測による検討. 呼吸不全に関する調査研究平成26年度総括・分担研究報告書. 2015. 207-209
Mika Kikkawa, Etsuko Kobayashi, Kuniaki Seyama, Masatoshi Kurihara, Hideyuki Kataoka, Yoshito Hoshika, Kazunori Tobino, Katsutoshi Ando, Makiko Kunogi, Yoko Gunji, et al. CLINICAL FEATURES AND GREMLIN FLCN MUTATIONS IN THE 152 UNRELATED FAMILIES WITH BIRT-HOGG-DUBE SYNDROME. RESPIROLOGY. 2013. 18. 11-11
小林悦子, 吉川美加, 瀬山邦明, 栗原正利, 片岡秀之, 星加義人, 久能木真喜子, 郡司陽子, 高橋和久. Birt-Hogg-Dube症候群152家系の遺伝子解析および臨床像の検討. 日本気胸・嚢胞性肺疾患学会雑誌. 2013. 13. 2. 160-160
瀬山邦明, 吉川美加, 星加義人, 片岡秀之, 栗原正利, 熊坂利夫, 飛野和則, 小林悦子, 安藤克利, 久能木真喜子, et al. Birt-Hogg-Dube症候群の遺伝子解析および臨床像. 日本呼吸器学会誌. 2012. 1. 増刊. 198-198

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Lectures and oral presentations (8)：

CLINICAL FEATURES AND GREMLIN FLCN MUTATIONS IN THE 152 UNRELATED FAMILIES WITH BIRT-HOGG-DUBE SYNDROME
(RESPIROLOGY 2013)
Flcn Mutation And Clinical Manifestations Of Patients With Birt-Hogg-Dub Syndrome Whose Presenting Feature Was Pnuemothrax And/or Multiple Lung Cysts
(AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2011)
FLCN mutation and clinical manifestations of patients with Birt-Hogg-Dube syndrome whose presenting feature was pnuemothrax and/or multiple lung cysts
(米国胸部学会 2011 (ATS2011) 2011)
FLCN mutation and clinical manifestations of patients with Birt-Hogg-Dube syndrome whose presenting feature was pnuemothrax and/or multiple lung cysts
(American Thoracic Society International Conference 2011 (ATS2011) 2011)
Mutation analysis of the Birt-Hogg-Dubé gene in patients with multiple lung cysts
(アジア太平洋呼吸器学会第14回大会 2009)

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Education (2)：

- 2000 Niigata University
- 2000 Niigata University Graduate School, Division of National Science and Technology

Work history (5)：

2000 - - 順天堂大学医学部助手(助教)
2000 - - Research Associate, Juntendo University
Biomolecular Science
Research Center Division of Proteomics and
Graduate School of Medicine BioMedical

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