Shiina Isamu | Researcher Information

天然薬理活性化合物の全合成
Asymmetric Total Synthesis of Natural Products

Yuuki OBATA, Kazuo KUROKAWA, Takuro TOJIMA, Miyuki NATSUME, Isamu SHIINA, Tsuyoshi TAKAHASHI, Ryo ABE, Akihiko NAKANO, Toshirou NISHIDA. Golgi retention and oncogenic KIT signaling via PLCγ2-PKD2-PI4KIIIβ activation in gastrointestinal stromal tumor cells. Cell Reports. 2023. 42. 9. 113035
Takatsugu MURATA, Hisazumi TSUTSUI, Takumi YOSHIDA, Hirokazu KUBOTA, Shintaro HIRAISHI, Hiyo NATSUKAWA, Yuki SUZUKI, Daiki HIRAGA, Takahiro MORI, Yutaro MAEKAWA, Satoru TATEYAMA, Kiyotaka TOYOYAMA, Keiichi ITO, Kyohei SUZUKI, Keita YONEKURA, Natsumi SHIBATA, Teruyuki SATO, Yasutaka TASAKI, Takehiko INOHANA, Atsuhiro TAKANO, Naoki EGASHIRA, Masaki HONDA, Yuma UMEZAKI, Isamu SHIINA. First Total Synthesis of Tanzawaic Acid B. ACS Omega. 2023. 8. 30. 27703-27709
Kouhei Yamawaki, Isamu Shiina, Takatsugu Murata, Satoru Tateyama, Yutarou Maekawa, Mariko Niwa, Motoyuki Shimonaka, Koji Okamoto, Toshihiro Suzuki, Toshirou Nishida, et al. FLT3-ITD transduces autonomous growth signals during its biosynthetic trafficking in acute myelogenous leukemia cells. Scientific reports. 2021. 11. 1. 22678-22678
Hiroharu SAKAI, Isamu SHIINA, Takahisa SHINOMIYA, Yukitoshi NAGAHARA. BRAP2 Inhibits the Ras/Raf/MEK and PI3K/Akt Pathways in Leukemia Cells, Thereby Inducing Apoptosis and Inhibiting Cell Growth. Experimental and Therapeutic Medicine. 2021. 21. 5. 463
Takayuki TONOI, Takehiko INOHANA, Ryo KAWAHARA, Teruyuki SATO, Miyuki IKEDA, Miku AKUTSU, Takatsugu MURATA, Isamu SHIINA. 4-(Dimethylamino)pyridine N-Oxide-Catalyzed Macrolactamization Using 2-Methyl-6-nitrobenzoic Anhydride in the Synthesis of the Depsipeptidic Analogue of FE399. ACS Omega. 2021. 6. 5. 3571-3577

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椎名勇. エステル・アミドって何? ラクトンって何? -理科大発! MNBAを用いた世界最速合成法の開発-. 理大科学フォーラム. 2019. 36. 6(通巻414). 28-33
椎名勇. 薬はどのような形をしているのか? -分子の形の調べ方, 掘り方と磨き方-. 「薬学図書館」(日本薬学図書館協議会機関誌)(ISSN 0386-2062)[Pharmaceutical Library Bulletin(Japan Pharmaceutical Library Association)]. 2017. 62. 3. 173-175
椎名勇, 森田明典. 新規タモキシフェン類縁体の放射線防護剤としての活性評価. 広島大学原爆放射線医科学研究所平成25年度共同利用・共同研究成果報告集(福島原発事故対応緊急プロジェクト研究). 2015. 13-13
椎名勇. 置換安息香酸無水物を用いる実用的縮合反応. ケミカルエンジニヤリング. 2006. 51. 702-706
椎名勇. 不斉触媒を活用した光学活性有機化合物の創製. (ハイテクリサーチセンター整備事業)「高度光利用グリーン科学技術研究センター」研究成果報告書. 2006. 2006. 45_46-114_117

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新規化合物及びその製造方法、並びに医薬組成物
ペプチド
BRAP2作用増強剤
BRAP2作用増強剤
安息香酸誘導体及び脱水縮合剤、並びにエステル及びラクトンの製造方法

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「有機分子触媒の開発と工業利用」(ファインケミカルシリーズ)第21章有機触媒を用いたカルボン酸誘導体および光学活性アルコールとカルボン酸の合成,ならびに医薬品合成への応用
(株)シーエムシー出版 2018
「理工系の基礎教養化学」(理工系の基礎シリーズIII)第6章4節医薬品
丸善(株) 2016
「有機合成法実験ハンドブック」(第2版)第29章複素環の合成
丸善(株) 2015
「有機合成法実験ハンドブック」(第2版)第16章カルボニル化合物の反応
丸善(株) 2015
「大学院講義有機化学 II」(第2版)第3章カルボン酸,ケトン,アルコールなどの変換反応
東京化学同人 2015

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Screening of compounds targeting chromosomes using fission yeast cells that have linear or circular chromosomes (Poster 123)
(The 11th Fission Yeast International Meeting (POMBE2023) 2023)
胆管癌細胞株に対するRidaifen-B誘導オートファジック細胞死の特性評価 (仙波さんが学生優秀発表賞(ポスター発表の部)を受賞:令和5年4月25日)
(日本薬学会第143年会 2023)
Ridaifen類縁体による低毒性なヒトケラチノサイトに対するオートファジー誘導
(日本薬学会第143年会 2023)
Ridaifen-BはRas/Raf/MEK/ERK経路およびPI3K/Akt経路を阻害することで難治癌にアポトーシスを誘導する
(日本薬学会第143年会 2023)
迅速脱水縮合剤MNBAを用いたエステル化反応に与える水の影響
(日本化学会第103春季年会(2023) 2023)

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- 1992 Tokyo University of Science Graduate School, Division of Natural Science Department of Chemistry
- 1990 Tokyo University of Science Faculty of Science Department of Applied Chemistry

Ph.D (The University of Tokyo)

2018/04 - Tokyo University of Science, Research Institute for Science and Technology Chemical Biology Division Supported by Practical Organic Synthesis Director of Chemical Biology Division Supported by Practical Organic Synthesis
2012/04 - 2017/03 Tokyo University of Science, Research Institute for Science and Technology Research Center for Chirality Director of Research Center for Chirality
2007 - 2008 Tokyo University of Science Associate Professor
2008 - Department of Applied Chemistry, Faculty of Science, Tokyo University of Science Professor
2003 - 2007 Tokyo University of Science Associate Professor

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2024/12/01 - 2025/11/30 The Society of Synthetic Organic Chemistry, Japan Delegates Committee Member
2023/12/01 - 2024/11/30 The Society of Synthetic Organic Chemistry, Japan Delegates Committee Member
2022/12/01 - 2023/11/30 The Society of Synthetic Organic Chemistry, Japan Delegates Committee Member
2023/09/08 - 2023/09/10 17th Symposium on Biorelevant Chemistry Organizing Committee
2021/12/01 - 2022/11/30 The Society of Synthetic Organic Chemistry, Japan Delegates Committee Member

2020/12/01 - 2021/11/30 The Society of Synthetic Organic Chemistry, Japan Delegates Committee Member

2019/12/01 - 2020/11/30 The Society of Synthetic Organic Chemistry, Japan Delegates Committee Member

2018/12/01 - 2019/11/30 The Society of Synthetic Organic Chemistry, Japan Delegates Committee Member

2017/12/01 - 2018/11/30 The Society of Synthetic Organic Chemistry, Japan Delegates Committee Member

2017/04/01 - 2018/03/31 The Chemical Society of Japan Annual Meeting Organization Committee

2016/04/01 - 2017/03/31 The Chemical Society of Japan Annual Meeting Organization Committee

2016/11/30 - 2016/11/30 15th Symposium on Chemical Approaches to Chirality Organizing Committee

2015/10/31 - 2016/10/28 The Chemical Society of Japan Delegates Committee Member

2015/11/18 - 2015/11/18 14th Symposium on Chemical Approaches to Chirality Organizing Committee

2014/04/01 - 2015/03/31 The Chemical Society of Japan Annual Meeting Organization Committee

2014/11/12 - 2014/11/12 13th Symposium on Chemical Approaches to Chirality Organizing Committee

2013/04/01 - 2014/03/31 The Chemical Society of Japan Annual Meeting Organization Committee

2013/03/01 - 2014/02/28 The Society of Synthetic Organic Chemistry, Japan Organizing Committee

2013/11/27 - 2013/11/27 12th Symposium on Chemical Approaches to Chirality Organizing Committee

2012/02/17 - 2013/02/28 The Society of Synthetic Organic Chemistry, Japan Organizing Committee

2012/09/26 - 2012/09/26 11th Symposium on Chemical Approaches to Chirality Organizing Committee

2011/04/01 - 2012/03/31 The Chemical Society of Japan Annual Meeting Organization Committee

2012/02/24 - 2012/02/24 10th Symposium on Chemical Approaches to Chirality Organizing Committee

2011/12/14 - 2011/12/14 9th Symposium on Chemical Approaches to Chirality Organizing Committee

2010/04/01 - 2011/03/31 The Chemical Society of Japan Annual Meeting Organization Committee

2010/12/01 - 2010/12/01 8th Symposium on Chemical Approaches to Chirality Organizing Committee

2010/09/29 - 2010/09/29 7th Symposium on Chemical Approaches to Chirality Organizing Committee

2009/11/25 - 2009/11/25 6th Symposium on Chemical Approaches to Chirality Organizing Committee

2008/04/01 - 2009/03/31 The Chemical Society of Japan Annual Meeting Organization Committee

2008/12/01 - 2008/12/01 5th Symposium on Chemical Approaches to Chirality Organizing Committee

2008/01/29 - 2008/01/29 4th Symposium on Chemical Approaches to Chirality Organizing Committee

2007/11/15 - 2007/11/15 3rd Symposium on Chemical Approaches to Chirality Organizing Committee

2005/11/10 - 2005/11/10 2nd Symposium on Chemical Approaches to Chirality Organizing Committee

2003/12/03 - 2003/12/03 1st Symposium on Chemical Approaches to Chirality Organizing Committee

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2023/02/13 - 2023 Chiba University Fungal Medicine Research Center Joint Research Project Selection
2021/11/25 - 9th DSANJ Digital Bio Conference AMED Invited Frame Research Results Selection
2021/04/20 - 2021 Chiba University Fungal Medicine Research Center Joint Research Project Selection
2021/02/10 - ACS Omega (ACS Publications) Cover Feature Article (2/2021)
2020/08/19 - European Journal of Organic Chemistry (European JOC) Cover Feature Article (8/2020)

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The Society of Synthetic Organic Chemistry, Japan , The Chemical Society of Japan , 9th Symposium on Chemical Approaches to Chirality , 8th Symposium on Chemical Approaches to Chirality , 7th Symposium on Chemical Approaches to Chirality , 6th Symposium on Chemical Approaches to Chirality , 5th Symposium on Chemical Approaches to Chirality , 4th Symposium on Chemical Approaches to Chirality , 3rd Symposium on Chemical Approaches to Chirality , 2nd Symposium on Chemical Approaches to Chirality , 1st Symposium on Chemical Approaches to Chirality , 15th Symposium on Chemical Approaches to Chirality , 14th Symposium on Chemical Approaches to Chirality , 13th Symposium on Chemical Approaches to Chirality , 12th Symposium on Chemical Approaches to Chirality , 11th Symposium on Chemical Approaches to Chirality , 10th Symposium on Chemical Approaches to Chirality