Nabe Takeshi

ナベタケシ | Nabe Takeshi

Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： http://www.setsunan.ac.jp/~p-yakko/

Research field (3)： Immunology , Clinical pharmacy , Pharmacology

Research keywords (12)： Pulmonary fibrosis , Group 2 innate lymphoid cells , Allergen immunotherapy , ステロイド性抗炎症薬 , interleukin-33 , regulatory T cells , atopic dermatitis , allergic conjunctivitis , allergic rhinitis , pollenosis , asthma , allergy

Research theme for competitive and other funds (11)：

2023 - 2027 Mechanisms of impaired olfactory epithelial regeneration in eosinophilic chronic rhinosinusitis: focusing on the involvement of type 2 cytokines.
2020 - 2023 Analyses of induction mechanisms underlying steroid-resistant asthma by focusing on "Epimmunome"
2020 - 2021 脂溶性ビタミン製剤はアレルゲン免疫療法のアジュバントになり得るか
2017 - 2020 スギ花粉症に対する経リンパ節免疫療法の実現に向けてー作用メカニズム解析を中心にー
2017 - 2020 IL-33産生機序の免疫学的解析を介した難治性喘息の病態解明

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Papers (144)：

Yuki Ohya, Yuri Ogiso, Masaya Matsuda, Harumi Sakae, Kentaro Nishida, Yasuhiro Miki, Todd E. Fox, Mark Kester, Wataru Sakamoto, Takeshi Nabe, et al. Pronecroptotic Therapy Using Ceramide Nanoliposomes Is Effective for Triple-Negative Breast Cancer Cells. Cells. 2024. 13. 5. 405-405
Hayato Shimora, Masaya Matsuda, Naoki Takemoto, Miku Nomura, Junpei Hamaguchi, Ryogo Terakawa, Miki Inaba, Kazuyuki Kitatani, Takeshi Nabe. Steroid-Insensitive Gene Expression of Extracellular Matrix Components and Pro-fibrotic Factors in the Lung Associated with Airway Hyperresponsiveness in Murine Asthma. Biological and Pharmaceutical Bulletin. 2024. 47. 1. 227-231
Keitaro Hayashi, Mayumi Saeki, Kento Miura, Norimasa Yamasaki, Masaya Matsuda, Hayato Shimora, Takeshi Nabe, Yasuo Shimizu, Tomoe Fujita, Hitoshi Endou, et al. JPH203, a LAT1 inhibitor, alleviates steroid-resistant murine airway inflammation mediated by Th17 cells. Allergy. 2023
Masanori Fujii, Shuhei Kobayashi, Ayane Ueda, Misaki Sakagami, Rieko Matsui, Yumeka Yamada, Takeshi Nabe, Susumu Ohya. STIM/Orai-mediated calcium entry elicits spontaneous TSLP overproduction in epidermal cells of atopic dermatitis mice. Exploration of Immunology. 2023. 174-185
Harumi Sakae, Yuri Ogiso, Masaya Matsuda, Hayato Shimora, Tye Deering, Todd E. Fox, Kester Mark, Takeshi Nabe, Kazuyuki Kitatani. Ceramide nanoliposomes as potential therapeutic reagents for asthma. Cells. 2023. 12. 4. 591

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MISC (53)：

Takeshi Nabe. Pathogenic changes in group 2 innate lymphoid cells (ILC2) in intractable asthma. Folia Pharmacologica Japonica. 2022. 157. 5. 299-304
Takeshi Nabe, Masaya Matsuda. Anti-inflammatory Strategies by Focusing on the Particularity of Ocular Immunity. YAKUGAKU ZASSHI. 2021. 141. 12. 1327-1332
松田将也, 寺田哲也, 北谷和之, 河田了, 奈邉健. 舌下免疫療法の効果発現における制御性T 細胞の役割. 日本耳鼻咽喉科免疫アレルギー感染症学会誌. 2021
Takeshi Nabe. Allergic inflammation and IL-33 production. The Allergy in Practice. 2021. 41. 2. 121-124
Masaya Matsuda, Tetsuya Terada, Kazuyuki Kitatani, Ryo Kawata, Takeshi Nabe. Analyses of regulatory T cells and regulatory B cells in subcutaneous immunotherapy-treated allergic individuals in humans and mice. Japanese Journal of Ocular Pharmacology. 2020. 34. 1. 87-89

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Books (11)：

Current Approaches to Allergic Rhinitis
Future Science, London 2014 ISBN:9781780844657
よくわかる治療薬ブック
照林社 2012
Advanced topics in Environmental health and air pollution case studies
2011
最新基礎薬理学第3版
廣川書店 2011
Pathophysiological and biochemical analyses of “Life-style related or intractable diseases”-Target validation for drug therapy-
Research Signpost, Kerala, India 2006 ISBN:9788130800646

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Lectures and oral presentations (49)：

特別講演「難治性アレルギー疾患の病態解析ならびに創薬標的の探索」
(第43回日本眼薬理学会(札幌) 2023)
シンポジウム「老化と眼疾患-いつまでも健康な視機能を-」眼免疫の特殊性とアンチエイジング
(日本薬学会第141年会 2021)
シンポジウム「免疫アレルギー疾患の克服に向けた新しい創薬ターゲット」オーバービュー
(第138回日本薬理学会近畿部会 2020)
Involvement of IL-5 produced from type 2 innate lymphoid cells (ILC2) in acquisition of steroid resistance in a severe asthma model of mice
(Japanese Society of Allergology (JSA)/World Allergy organization (WAO) Joint Congress 2020 2020)
Involvement of type 1 regulatory T (Tr1) in clinical effectiveness of sublingual immunotherapy (SLIT)
(Japanese Society of Allergology (JSA)/World Allergy organization (WAO) Joint Congress 2020 2020)

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Works (11)：

ステロイド抵抗性喘息の発症機序と制御に関する研究
奈邉健 2016 - 現在
Studies on mechanisms of allergen immunotherapy
Takeshi Nabe 2015 - 現在
気管支喘息におけるIL-33の病態生理学的役割
奈邉健 2011 - 現在
アレルギー疾患における制御性T細胞の役割
奈邉健 2010 - 現在
アレルギー性結膜炎の発症機序に関する研究
奈邉健 1998 - 現在

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Education (4)：

2001 - 2002 University of Alabama at Birmingham Department of Microbiology
1998 - Kyoto Pharmaceutical University
1988 - 1990 Kyoto Pharmaceutical University
1984 - 1988 Kyoto Pharmaceutical University Pharmaceutical Sciences Pharmacy

Professional career (2)：

Master of Pharmaceutical Science (Kyoto Pharmaceutical University)
Doctor of Pharmaceutical Science (Kyoto Pharmaceutical University)

Work history (6)：

2014 - 現在 Setsunan University Faculty of Pharmaceutical Sciences Professor
2007 - 2014 Kyoto Pharmaceutical University
2001 - 2007 Kyoto Pharmaceutical University
2001 - 2002 University of Alabama at Birmingham, Visiting Researcher
1999 - 2000 Kyoto Pharmaceutical University

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Committee career (10)：

2023/01 - 現在日本免疫学会評議員
2022/11 - 現在 Frontiers in Immunology Associate Editor
2021/04 - 現在日本薬学会関西支部幹事
2018/04 - 現在日本眼薬理学会理事・評議員
2017/04 - 現在日本薬学会代議員

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Awards (2)：

2015/11 - 日本薬学会医薬化学部会平成27年度日本薬学会メディシナルケミストリーシンポジウム優秀賞
2015 - Journal of Pharmacological Sciences Excellent Reviewer Award 2015

Association Membership(s) (5)：

日本免疫学会 , 日本眼薬理学会 , 日本薬学会 , 日本アレルギー学会 , 日本薬理学会

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