Rchr
J-GLOBAL ID:200901054107385682
Update date: Apr. 17, 2024
Kojima Naoto
コジマ ナオト | Kojima Naoto
Affiliation and department:
Job title:
Professor
Research field (3):
Pharmaceuticals - chemistry and drug development
, Synthetic organic chemistry
, Bioorganic chemistry
Research keywords (5):
生物活性物質
, 含フッ素ビルディングブロック
, 有機合成化学
, 抗腫瘍活性物質
, organic chemistry
Research theme for competitive and other funds (15):
- 2016 - 2022 新規抗がん剤の創製を指向したアセトゲニン誘導体のTHF環部分の構造活性相関研究
- 2015 - 2021 新規分子標的治療薬創薬に向けた大学発ベンチャー基盤の確立
- 2013 - 2016 新規抗がんリードの創出を目指すデュアルコア型アセトゲニン類の構造活性相関研究
- 2012 - 2015 Basic studies of therapeutic modality for polycystic kidney disease explored by epigenetic modification of cellular matrix-adhesion proteins
- 2010 - 2013 Development of novel synthetic reactions based on release of strain energy in small ring system and its application to total syntheses of natural products
- 2011 - 2013 Structure-activity relationship study of hybrid acetogenins toward the practical use
- 2010 - 2013 Synthetic study of novel antitumor agents
- 2010 - 2012 Discovery of innovative molecular targeted drugs based on Cancer Cell Informatics
- 2010 - 2012 Development of synthetic methodology to supply materials for understanding of physiological system
- 2009 - 2010 Synthesis and biological evaluation of hybrid acetogenins for the discovery of novel antitumor agents
- 2006 - 2008 Development of novel metal-mediated reaction and their application to domino cyclization
- 2006 - 2007 多成分縮合ドミノ型反応による複雑な複素環のワンポット合成法の開発
- 2006 - 2007 HIF-1α阻害剤マナサンチンBのバイオプローブ化
- 2002 - 2003 多剤耐性癌の薬物治療を指向したアセトゲニン類の系統的不斉合成法の開発
- Studies toward Asymmetric Synthesis of an Antitumor Annonaceous Acetogenins
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Papers (69):
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Hiroki Iwasaki, Mari Ikemoto, Haruka Shibata, Yuka Shima, Erina Himeno, Naoto Kojima, Masayuki Yamashita, Hisanori Nambu. Regioselective SmI2-Mediated Radical ipso-Substitution Cyclization for the Construction of Pyrrolophenanthridinone Skeletons: The Synthesis of Amaryllidaceae Alkaloids. Chemical and Pharmaceutical Bulletin. 2023. 71. 7. 515-519
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Kaito Ohta, Hiromi Ii, Chiami Moyama, Shota Ando, Hisanori Nambu, Susumu Nakata, Naoto Kojima. Thiophene Carboxamide Analogs with Long Alkyl Chains Comprising Ethylene Glycol Units Inhibit Glioblastoma Cell Proliferation by Activating AMPK. Journal of Medicinal Chemistry. 2023. 66. 6403-6413
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Takuya Matsumoto, Saya Okazaki, Shui Aoki, Aya Niki, Hiroki Iwasaki, Minoru Ozeki, Masayuki Yamashita, Naoto Kojima, Ikuo Kawasaki. Facile synthesis of 5-alkoxy-4-aryltetrahydrofuran-2-one using hypervalent iodine reagents. Tetrahedron Letters. 2023. 118. 154382-154382
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Hiroyuki Hosomi, Akinobu Akatsuka, Shingo Dan, Hiroki Iwasaki, Hisanori Nambu, Naoto Kojima. Synthesis of Acetogenin Analogs Comprising Pyrimidine Moieties Linked by Amine Bonds and Their Inhibitory Activity against Human Cancer Cell Lines. Chemical and Pharmaceutical Bulletin. 2022. 70. 11. 823-826
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Shota Ando, Naoto Kojima, Chiami Moyama, Mitsugu Fujita, Kaito Ohta, Hiromi Ii, Susumu Nakata. JCI-20679 suppresses the proliferation of glioblastoma stem cells by activating AMPK and decreasing NFATc2 expression levels. Molecular Medicine Reports. 2022. 26. 1. 238
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MISC (23):
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大田海斗. N-トリエチレングリコール含有アルキル-3-チオフェンカルボキサミド誘導体の合成と膠芽腫に対する生物活性の評価. 第73回日本薬学会関西支部総会・大会 優秀口頭発表賞. 2023
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中田晋, 小島直人. Novel AMPK activators inhibiting mitochondrial complex I that attack glioblastoma, and colon/lung cancer. 日本癌学会学術総会抄録集(Web). 2023. 82nd
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大田海斗, 藤井真人, 茂山千愛美, 飯居宏美, 中田晋, 岩崎宏樹, 山下正行, 南部寿則, 小島直人. Synthesis and Antitumor Activity of Novel Analog of Acetogenin Thiophene Analog with Triethylene Glycol in place of THF Moiety. 日本薬学会年会要旨集(Web). 2023. 143rd
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細見紘幸, 小柴佐和子, 松本卓也, 安藤翔太, 茂山千愛美, 飯居宏美, 中田晋, 岩崎宏樹, 山下正行, 南部寿則, et al. Synthesis of Acetogenin Thiophene Analogs Conformationally Fixed by Cyclopentane Rings and Clarification Research of Molecular Mechanism. 日本薬学会年会要旨集(Web). 2023. 143rd
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高橋達哉, 大田海斗, 竜石侑璃, 安藤翔太, 茂山千愛美, 飯居宏美, 中田晋, 岩崎宏樹, 山下正行, 南部寿則, et al. Synthesis of Thiophene Carboxamides with Alkyl Chain Comprising Ethylene Glycol Units, and Their Growth Inhibitory Activity against Glioblastoma Stem Cells. 日本薬学会年会要旨集(Web). 2023. 143rd
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Patents (5):
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NOVEL AMP-ACTIVATED PROTEIN KINASE ACTIVATOR
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新規なAMP活性化プロテインキナーゼ活性化剤
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ヒトのがん細胞の増殖を抑制するため化合物及び医薬
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新規ベンゾイソフラノン誘導体による臓器組織の修復再生治療薬
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5,6-ジヒドロ-5-トリフルオロメチルウラシルの分解方法
Lectures and oral presentations (282):
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新規アセトゲニン誘導体のヒト肺がんA549細胞担癌マウスにおける抗腫瘍効果
(日本薬学会第144年会 2024)
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新規アセトゲニン誘導体は大腸がん担癌マウスにおいて抗腫瘍効果を示す
(日本薬学会第144年会 2024)
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エチレングリコール単位を含む<i>N</i>-アルキルチオフェンカルボキサミドの合成とヒト肺がん細胞A549に対する効果:エチレングリコール単位、テール、およびリンカー部の検討
(日本薬学会第144年会 2024)
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真菌<i>Curvuralia moringae</i>代謝産物中のがん幹細胞増殖抑制活性物質の探索
(日本薬学会第144年会 2024)
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N-トリエチレングリコール含有アルキル-3-カルボキサミドの合成と膠芽腫に対する抗腫瘍効果
(第40 回日本薬学会九州山口支部大会 2023)
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Education (3):
- 2001 - 2004 Osaka University Graduate School of Pharmaceutical Sciences Ph.D.
- 1999 - 2001 Osaka University Graduate School of Pharmaceutical Sciences M.sc.
- 1995 - 1999 Osaka University School of Pharmaceutical Sciences B.Sc.
Professional career (2):
- (BLANK) (Osaka University)
- Ph.D (Osaka University)
Work history (7):
- 2023/04 - 現在 Nagasaki International University Faculty of Pharmaceutical Sciences Professor
- 2017/04 - 2023/03 Kyoto Pharmaceutical University Pharmaceutical Sciences Associate professor
- 2012/04 - 2017/03 Kyoto Pharmaceutical University Pharmaceutical Sciences Lecturer (full time)
- 2007/04 - 2012/03 Osaka University Graduate School of Pharmaceutical Sciences Assistant professor
- 2005/09 - 2007/03 Osaka University Graduate School of Pharmaceutical Sciences Research associate
- 2004/04 - 2005/08 Sagami Chemical Research Institute Research scientist
- 2002/04 - 2004/03 Japan Society for the Promotion of Science Research fellowship for young scientists
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Committee career (3):
- 2014/02 - 2023/01 有機合成化学協会 関西支部 幹事
- 2019/04 - 2021/03 日本薬学会 代議員
- 2013/04 - 2017/03 日本薬学会 代議員
Awards (6):
Association Membership(s) (5):
日本薬学教育学会
, アメリカ化学会
, THE JAPANESE ASSOCIATION FOR MOLECULAR TARGET THERAPY OF CANCER
, 有機合成化学協会
, 日本薬学会
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