Rchr
J-GLOBAL ID：200901054348497880   Update date: Apr. 03, 2024

Shimizu Toshiyuki

シミズ トシユキ | Shimizu Toshiyuki
Affiliation and department：
-

About -


Homepage URL  (1)： http://www.f.u-tokyo.ac.jp/~kouzou/
Research field  (2)： Biophysics ,  Structural biochemistry
Research keywords  (8)： intracellular signaling ,  innate immunity ,  シグナル伝達 ,  自然免疫 ,  構造生物学 ,  X線結晶構造解析 ,  CryoEM ,  Structural Biology
Research theme for competitive and other funds  (31)：
  • 2023 - 2027 Lysosomes as the starting point of innate immune responses - importance of lysosomal environment -
  • 2022 - 2027 Molecular and structural bases enabling self-derived nucleic acid recognition in lysosomes
  • 2021 - 2026 Toll様受容体の応答を決定する時空間リソソームダイナミクス
  • 2021 - 2023 糖鎖を利用したクライオ電子顕微鏡解析の問題克服と自然免疫受容体TLRへの応用
  • 2019 - 2022 Elucidation of molecular motion and new regulation mechanisms in innate immune sensors
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Papers (180)：
  • Zhikuan Zhang, Takuma Shibata, Akiko Fujimura, Jiro Kitaura, Kensuke Miyake, Umeharu Ohto, Toshiyuki Shimizu. Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome. Nature. 2023. 622. 7981. 188-194
  • Honami Echizen, Kenjiro Hanaoka, Kazuhito Shimamoto, Ryota Hibi, Sachiko Toma-Fukai, Hisashi Ohno, Eita Sasaki, Toru Komatsu, Tasuku Ueno, Yukihiro Tsuchiya, et al. Discovery of a cystathionine γ-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5'-phosphate (PLP) via Schiff base formation. Scientific reports. 2023. 13. 1. 16456-16456
  • Kentaro Sakaniwa, Akiko Fujimura, Takuma Shibata, Hideki Shigematsu, Toru Ekimoto, Masaki Yamamoto, Mitsunori Ikeguchi, Kensuke Miyake, Umeharu Ohto, Toshiyuki Shimizu. TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction. Nature Communications. 2023. 14. 1
  • Sachiko Toma-Fukai, Yuto Sawada, Ayako Maeda, Hikaru Shimizu, Toshiharu Shikanai, Mizuki Takenaka, Toshiyuki Shimizu. Structural insight into the activation of an Arabidopsis organellar C-to-U RNA editing enzyme by active site complementation. The Plant cell. 2022
  • Takuma Shibata, Ryota Sato, Masato Taoka, Shin-Ichiroh Saitoh, Mayumi Komine, Kiyoshi Yamaguchi, Susumu Goyama, Yuji Motoi, Jiro Kitaura, Kumi Izawa, et al. TLR7/8 stress response drives histiocytosis in SLC29A3 disorders. 2022
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MISC (88)：
  • 竹中瑞樹, 藤間祥子, BRODY Frink, WANG Tenghua, 竹中佐知, 鹿内利治, 清水敏之. Activation of a plant organellar C-to-U RNA editing enzyme by complex formation. 日本植物生理学会年会(Web). 2023. 64th
  • 藤間祥子, 中村雄太郎, 寺谷俊昭, 川本晃大, 清水光, 廣瀬未果, 端山浩輝, 大畑慎也, 林有吾, 山崎洋一, et al. Structural insight into the nuclear transport mechanism of PPARg. 日本薬学会年会要旨集(Web). 2022. 142nd
  • 藤間祥子, 藤間祥子, 澤田優斗, 前田彩子, 清水光, 鹿内利治, 竹中瑞樹, 清水敏之. Structural study of plant organellar C-to-U RNA editing enzyme DYW-1. 量子ビームサイエンスフェスタ(Web). 2022. 2021
  • 藤間祥子, 端山浩輝, 松浦滉明, 坂井直樹, 平田邦生, 松谷優輝, 清水光, 大畑慎也, 林有吾, 山崎洋一, et al. 強度クラスタリング法を利用した蛋白質複合体の結晶内構造多型の同定. 日本結晶学会年会講演要旨集. 2020. 2020 (CD-ROM)
  • 内田有紀, 栄祐美, 松谷優輝, 石井雅樹, 藤間祥子, 藤間祥子, 清水敏之, 堅田利明, 堅田利明, 大畑慎也, et al. 上衣腫原因融合タンパク質C11orf95-RelAの核移行機構. 日本薬学会関東支部大会講演要旨集. 2020. 64th
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Education (2)：
  • - 1989 The University of Tokyo
  • - 1987 The University of Tokyo Faculty of Pharmaceutical Sciences
Professional career (1)：
  • (BLANK)
Work history (7)：
  • 2010/05 - 現在 The University of Tokyo Graduate School of Pharmaceutical Sciences
  • 2009/04 - 2010/04 Yokohama City University
  • 2005/04 - 2009/03 Yokohama City University
  • 2001/04 - 2005/03 Yokohama City University
  • 1995 - 2001 Nara Institute of Science and Technology Graduate School of Biological Sciences
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Awards (1)：
  • 2007 - 薬学研究ビジョン部会賞
Association Membership(s) (4)：
THE CRYSTALLOGRAPHIC SOCIETY OF JAPAN ,  日本蛋白質科学会 ,  日本生化学会 ,  日本薬学会
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