Rchr
J-GLOBAL ID:200901054486969629   Update date: Apr. 17, 2024

Nagata Shigekazu

ナガタ シゲカズ | Nagata Shigekazu
Affiliation and department:
Job title: 特任教授(常勤)
Homepage URL  (2): http://biochemi.ifrec.osaka-u.ac.jp/http://biochemi.ifrec.osaka-u.ac.jp/english/index.html
Research field  (3): Medical biochemistry ,  Cell biology ,  Molecular biology
Research keywords  (4): Immunology ,  Biochemistry ,  Cell Biology ,  Molecular Biology
Research theme for competitive and other funds  (63):
  • 2021 - 2024 スクランブラーゼの作用機構とフリッパーゼの基質特異性の解明
  • 2015 - 2020 Engulfment of apoptotic cells and asymmetry of plasma membranes
  • 2010 - 2015 Molecular mechanism of the engulfment and degradation of dead cells by macrophages
  • 2005 - 2009 Molecular Mechanism of Cell Death And Its Physiological Role
  • 2005 - 2005 細胞死の分子機構
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Papers (401):
  • Takaharu Sakuragi, Ryuta Kanai, Mayumi Otani, Masahide Kikkawa, Chikashi Toyoshima, Shigekazu Nagata. The role of the C-terminal tail region as a plug to regulate XKR8 lipid scramblase. The Journal of biological chemistry. 2024. 300. 3. 105755-105755
  • Takaharu Sakuragi, Shigekazu Nagata. Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases. Nature Reviews Molecular Cell Biology. 2023
  • Yugo Miyata, Kyoko Yamada, Shigekazu Nagata, Katsumori Segawa. Two types of type IV P-type ATPases independently re-establish the asymmetrical distribution of phosphatidylserine in plasma membranes. The Journal of biological chemistry. 2022. 298. 11. 102527-102527
  • Yuta Ryoden, Shigekazu Nagata. The XK plasma membrane scramblase and the VPS13A cytosolic lipid transporter for ATP-induced cell death. BioEssays : news and reviews in molecular, cellular and developmental biology. 2022. 44. 10. e2200106
  • Yuki Ochiai, Chigure Suzuki, Katsumori Segawa, Yasuo Uchiyama, Shigekazu Nagata. Inefficient development of syncytiotrophoblasts in the Atp11a-deficient mouse placenta. Proceedings of the National Academy of Sciences of the United States of America. 2022. 119. 18. e2200582119
more...
MISC (119):
  • 中西華代, 西澤知宏, 瀬川勝盛, 濡木理, 藤吉好則, 長田重一, 阿部一啓, 阿部一啓. Crystal and cryo-EM structures of phospholipid flippase ATP11C, a ”Death Pump”. 日本生体エネルギー研究会討論会講演要旨集. 2020. 46th
  • 瀬川 勝盛, 長田 重一. リン脂質フリッパーゼとB細胞分化. 臨床免疫・アレルギー科. 2019. 72. 1. 80-86
  • 瀬川 勝盛, 長田 重一. 【細胞死 新しい実行メカニズムの謎に迫り疾患を理解する ネクロプトーシス、パイロトーシス、フェロトーシスとは?死を契機に引き起こされる免疫、炎症、再生の分子機構とは?】(第2章)死細胞の認識、貪食、生体応答 リン脂質フリッパーゼとアポトーシス細胞の認識. 実験医学. 2016. 34. 7. 1082-1088
  • 鈴木 淳, 長田 重一. 【細胞死 新しい実行メカニズムの謎に迫り疾患を理解する ネクロプトーシス、パイロトーシス、フェロトーシスとは?死を契機に引き起こされる免疫、炎症、再生の分子機構とは?】(第2章)死細胞の認識、貪食、生体応答 スクランブラーゼによるホスファチジルセリンの露出. 実験医学. 2016. 34. 7. 1076-1081
  • 長田 重一. 将来を見据えた脂質生物学 細胞死と"eat me"シグナル. 脂質生化学研究. 2015. 57. 15-15
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Patents (4):
  • 生体内のアポトーシス細胞の除去促進剤及び除去阻害剤
  • Method of screening a blood coagulation modulator
  • DNase II 遺伝子機能欠損貧血症モデル非ヒト動物
  • 生体内のアポトーシス細胞の除去促進剤および除去阻害剤
Books (9):
  • Apoptotic and non-apoptotic cell death
    Springer 2017 ISBN:9783319239125
  • Cell biology: Killer enzymes tethered
    Nature 2016
  • 長田重一教授退官記念誌
    長田重一教授退官記念事業実行委員会 2015
  • Engulfment of apoptotic cells and its physiological roles.
    In: Cell Death, Gerry Melino, and D. Vaux, eds. (John Wiley & Sons) pp.165-175 2012
  • 終末への道筋 -アポトーシスとさまざまな細胞死-
    メディカル・サイエンス・インターナショナル 2012
more...
Lectures and oral presentations  (349):
  • Phosphatidylserine-Dependent Efferocytosis and Entosis
    (The 2019 Keystone Symposia on Why So Many Ways to Die? Apoptosis, Necroptosis, Pyroptosis and Beyond 2019)
  • Phosphatidylserine-dependent efferocytosis
    (Seminar at Centre d'Immunologie de Marseille-Luminy, Marseille, France 2019)
  • Phosphatidylserine-dependent efferocytosis
    (Seminar at Necker Hospital, Paris, FRANCE 2019)
  • Flippases and scramblases for phosphatidylserine-exposure
    (The EMBO Workshop on "Cell Death, Immunity and Inflammation", Kalimera Kriti Hotel & Village Resort, Crete, GREEC 2019)
  • Phosphatidylserine-dependent efferocytosis and entosis
    (ECDO Honorary Prize from European Cell Death Organization (ECDO), The 27th Euroconference on Apoptosis "Cell Death and Regeneration", The Hilton Dresden, Dresden, GERMANY 2019)
more...
Works (7):
  • 特別推進研究 細胞死の分子機構とその生理作用
    2005 - 2009
  • アポトーシスと貪食の分子機構とその生理作用
    2003 - 2008
  • Molecular mechanism and physiological role of apoptosis and engulfment
    2003 - 2008
  • 特定領域研究(2) 先端がん 細胞死の分子機構とその生理作用の解析
    2000 - 2004
  • アポトーシスにおけるゲノム構造変化の分子機構
    1998 - 2003
more...
Education (3):
  • 1972 - 1977 The University of Tokyo
  • 1968 - 1972 The University of Tokyo Faculty of Science
  • 1965 - 1968 Kanazawa University High School
Professional career (1):
  • Ph.D. (The University of Tokyo)
Work history (11):
  • 2015 - 現在 Osaka University WPI Immunology Frontier Research Center Distinguished Professor
  • 2007 - 2015 Department of Medical Chemistry, Graduate School of Medicine, Kyoto University
  • 2010/10 - 2013/09 Kyoto University Graduate School of Medicine Deputy Dean
  • 1999/04 - 2008/03 Osaka University Graduate School of Medicine Professor
  • 2004/04 - 2007/03 Osaka University Councilor
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Committee career (12):
  • 2018 - 現在 Human Frontier Science Program Organization President
  • 1999 - 現在 Cancer Cell Editorial Board
  • 1998 - 現在 Immunity Editorial Board
  • 1994 - 現在 Cell death and Diff Editorial Board
  • 2006 - 2009 Human Frontier Science Program Organization Councils of Scientists
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Awards (29):
  • 2022/11 - The Order of the Sacred Treasure, Gold and Silver Star
  • 2021/10 - Australasian Cell Death Society (Australia) The Pioneers of the Australasian Cell Death Society
  • 2021/02 - American Association for Cancer Research (AACR) Fellow of the AACR Academy
  • 2019 - European Cell Death Organization ECDO Honorary Prize
  • 2017/06 - CDD Scientific Committee, Springer Nature The 2017 CDD Award
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Association Membership(s) (4):
日本免疫学会 ,  日本癌学会 ,  日本分子生物学会 ,  日本生化学会
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