Kutsumura Noriki

クツムラノリキ | Kutsumura Noriki

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://nagase.wpi-iiis.tsukuba.ac.jp/members/kutsumura.php

Research field (5)： Pharmaceuticals - chemistry and drug development , Synthetic organic chemistry , Bioorganic chemistry , Structural/physical organic chemistry , Molecular biochemistry

Research keywords (4)： Organic Synthetic Chemistry , Medicinal Chemistry , Heterocyclic Chemistry , Natural Product Chemistry

Research theme for competitive and other funds (15)：

2020 - 2022 Elucidation of novel itch transmission pathway and development of seed compounds for treating itch
2019 - 2022 Synthesis of morphinan compounds having drug-resistance reversal activity against drug-resistant malaria and the influence of thiol group-trapping ability
2019 - 2020 MRGPRX2の新規リガンド合成と、関連疾患の作用機序解明
2017 - 2019 Elucidation of an action mechanism of BNTX derivatives toward antitrichomonal activity and the structure activity relationship
2018 - 2018 MRGPRX2に作用するリガンドの探索研究

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Papers (84)：

Kenta Maeda, Tomoya Sugai, Akihisa Tokuda, Keita Kajino, Tsuyoshi Saitoh, Hiroshi Nagase, Noriki Kutsumura. Design and synthesis of unique morphinan-type molecules: Their application to the search for the unexplored binding domain between opioid receptors and morphinan ligands. Bioorganic & medicinal chemistry letters. 2024. 99. 129611-129611
Kenta Maeda, Sayaka Ohrui, Akihisa Tokuda, Yasuyuki Nagumo, Naoshi Yamamoto, Ryuji Tanimura, Tsuyoshi Saitoh, Noriki Kutsumura, Hiroshi Nagase. Unexpected Rearrangement Reactions of the 14-Aminonaltrexone Skeleton. Organic letters. 2023. 25. 19. 3407-3411
Iio, Keita, Hashimoto, Kao, Nagumo, Yasuyuki, Amezawa, Mao, Hasegawa, Taisei, Yamamoto, Naoshi, Kutsumura, Noriki, Takeuchi, Katsuhiko, Ishikawa, Yukiko, Yamamoto, Hikari, et al. Design and Synthesis of Orexin 1 Receptor-Selective Agonists. Journal of Medicinal Chemistry. 2023. 66. 8. 5453-5464
Amezawa, Mao, Yamamoto, Naoshi, Nagumo, Yasuyuki, Kutsumura, Noriki, Ishikawa, Yukiko, Yanagisawa, Masashi, Nagase, Hiroshi, Saitoh, Tsuyoshi. Design and synthesis of novel orexin 2 receptor agonists with a 1,3,-trioxazatriquinane skeleton. Bioorganic & Medicinal Chemistry Letters. 2023. 82. 129151
Tsuyoshi Saitoh, Mao Amezawa, Jumpei Horiuchi, Yasuyuki Nagumo, Naoshi Yamamoto, Noriki Kutsumura, Ryuichiro Ohshita, Akihisa Tokuda, Yoko Irukayama-Tomobe, Yasuhiro Ogawa, et al. Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) library. European journal of medicinal chemistry. 2022. 240. 114505-114505

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MISC (49)：

長尾るぶりか, 長尾るぶりか, 須貝智也, 西田彗, 西田彗, 石川有紀子, 上田壮志, 柳沢正史, 柳沢正史, 沓村憲樹, et al. Design and Synthesis of 2,4,5-Trisubstituted Pyrimidine-centred Kinase Inhibitors. 日本薬学会年会要旨集(Web). 2023. 143rd
内山広希, 内山広希, 須貝智也, 西田彗, 西田彗, 石川有紀子, 上田壮志, 柳沢正史, 柳沢正史, 沓村憲樹, et al. Development of a Novel Salt-Inducible Kinase Activator. 日本薬学会年会要旨集(Web). 2023. 143rd
高山良明, 高山良明, 須貝智也, 西田彗, 西田彗, 石川有紀子, 上田壮志, 柳沢正史, 柳沢正史, 沓村憲樹, et al. Structure-Activity Relationship Study of Flavonol Derivatives for Salt-Inducible Kinase. 日本薬学会年会要旨集(Web). 2023. 143rd
雨澤真櫻, 斉藤毅, 山本直司, 沓村憲樹, 沓村憲樹, 南雲康行, 石川有紀子, 入鹿山容子, 柳沢正史, 長瀬博, et al. Discovery of Novel Orexin Receptor Agonist with 1,3,5-Trioxazatriquinane Skeleton. 日本薬学会年会要旨集(Web). 2021. 141st
徳田明久, 南雲康行, 片山璃沙子, 上田壮志, 上園保仁, 山本直司, 斉藤毅, 斉藤毅, 沓村憲樹, 沓村憲樹, et al. δオピオイド受容体作動薬のストレス誘発うつ様症状の治療効果とその副作用発現機序の解明. 鎮痛薬・オピオイドペプチドシンポジウムプログラム・抄録集. 2021. 40th

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Patents (2)：

スルホンアミド誘導体またはその薬学的に許容される酸付加塩
Sulfonamide Derivatives or Their Pharmaceutical Acceptable Acid Salts

Books (3)：

アルカロイドの科学-生物活性を生みだす物質の探索から創薬の実際まで-
化学同人 2017 ISBN:9784759814187
動物/疾患モデルの作成技術・病態解析・評価手法
技術情報協会 2017 ISBN:9784861046650
Cross Conjugation: Modern Dendralene, Radialene and Fulvene Chemistry
Wiley-VCH 2016 ISBN:9783527334377

Lectures and oral presentations (37)：

新たな痒み伝達経路の解明と掻痒症治療シーズの開発
(化学コミュニケーションのフロンティア取り纏めシンポジウム 2022)
Drug Discovery Research Targeting Orexin Receptors in Academia
(Neuro2022 2022)
有機合成化学を武器に睡眠の謎に迫る
(阿南工業高等専門学校「創造技術セミナー」 2022)
薬を創る
(東京理科大学大学院理学研究科「化学特別講義」 2021)
新たな痒み伝達経路の解明と掻痒症治療シーズの開発
(2020)

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Education (2)：

2001 - 2006 Keio University Graduate School of Science and Technology School of Fundamental Science and Technology
1997 - 2001 Keio University Faculty of Science and Technology Department of Chemistry

Professional career (1)：

Doctorate of Science (Keio University)

Work history (18)：

2022/04 - 現在 University of Tsukuba Faculty of Pure and Applied Sciences/WPI-IIIS Professor
2021/04 - 現在 University of Tsukuba
2020/04 - 現在 Tokyo University of Science
2020/04 - 現在 University of Tsukuba
2020/04 - 現在 University of Tsukuba

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Committee career (14)：

2023/04 - 現在日本化学会関東支部各賞推薦委員会副委員長
2023/03 - 現在日本化学会関東支部常任幹事
2022/10 - 現在日本化学会関東支部代議員
2022/05 - 現在独立行政法人日本学生支援機構国費外国人留学生選考委員会専門部会委員
2022/04 - 現在文部科学省国費外国人留学生選考委員

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Awards (10)：

2017 - Highly Read Article of 2015 in Journal of Medicinal Chemistry Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists
2015 - Featured Article of Journal of Medicinal Chemistry Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists
2015 - Award for Excellent Presentation, 33rd Medicinal Chemistry Symposium, DMC, PSJ in 2015
2014 - 第34回鎮痛薬・オピオイドペプチドシンポジウム優秀演題賞オピオイド拮抗薬の薬剤耐性マラリアの耐性解除作用
2013 - 新化学技術推進協会第2回新化学技術研究奨励賞新奇L字型縮巻化合物ライブラリーの構築と構造物性相関研究

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Association Membership(s) (11)：

鎮痛薬・オピオイドペプチド研究会 , 日本薬学会医薬化学部会 , THE PHARMACEUTICAL SOCIETY OF JAPAN , 新規素材探索研究会 , 有機電気化学研究会 , アメリカ化学会 , 有機合成化学協会 , 日本化学会 , Amecican Chemical Society , The Society of Synthetic Organic Chemistry, Japan , THE CHEMICAL SOCIETY OF JAPAN

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