Rchr

J-GLOBAL ID：200901055052354690 Update date: Apr. 06, 2024

Aoki Junken

アオキジユンケン | Aoki Junken

Affiliation and department：
Job title：教授
Homepage URL (2)： http://db.tohoku.ac.jp/whois/detail/269b5fbf825ea70139d27a5d42e4daaa.html , http://db.tohoku.ac.jp/whois/e_detail/269b5fbf825ea70139d27a5d42e4daaa.html

Research field (1)： Applied biochemistry

Research keywords (5)： lysophosphatidylserine , lysophosphatidic acid , phospholipase , GPCR , lysophospholipid

Research theme for competitive and other funds (51)：

2023 - 2027 Stratification of depression based on lysophospholipid metabolic disorders and innovative development of novel antidepressants
2022 - 2025 Elucidation of immunoregulatory roles of lysophospholipid mediators and their pharmacological significance
2020 - 2023 多種多様な脂肪酸種で構成されるリン脂質分子種の意義解明
2019 - 2022 Identification of synthetic pathway for lysophosphatidylserine in activated lymphocytes.
2015 - 2020 Analyses of membrane phospholipid quality

2017 - 2019 Role of lysophospholipid produced upon cell death.

2016 - 2019 A novel immunomodulatory role of a lysophospholipid mediator, lysophosphatidylserine,, in lynphocytes.

2015 - 2019 Expansion of the study of Oxytocin Receptor, which has diverse physiological functions, and establishment of a new agonist analysing system.

2016 - 2018 Identification and functional analysis of a mast cell lysophosphatidylserine receptor.

2014 - 2016 Intracellular roles of 2-acyl-lysophospholipids

2013 - 2016 Immunosuppressive role of lysophosphatidylserine and its evaluation as drug targets

2010 - 2016 Lipid machinery

2013 - 2015 The study for suppression of obliterative bronchiolitis by inhibiting autotaxin activity

2010 - 2015 Comprehensive analysis of lysophospholipids using model animals

2012 - 2014 Biological roles of fatty acid composition of phospholipids.

2010 - 2011 Identification of a novel GPCR for oxidized LDL and its role in development of arteriosclerosis.

2009 - 2011 Comprehensive analyses of bioactive lysophospholipids

2008 - 2009 The functions of autotaxin in the regulation of blood vessel formation

2007 - 2008 新規スレオニン含有リン脂質のマスト細胞における機能と産生機構の解明

2007 - 2008 Patho-physiological role of bioactive lysophospholipids

2006 - 2007 新規細胞内型ホスホリパーゼA1による逆行性輸送制御機構の解明

2006 - 2007 生理活性脂質リゾホスファチジン酸による血管新生・細胞浸潤・転移制御とその意義

2006 - 2006 マスト細胞の多様性とその意義

2005 - 2006 Patho-Physiological role of lysophosphatidic acid.

2005 - 2005 生理活性脂質リゾホスファチジン酸によるがん細胞の増殖・浸潤制御とその意義

2001 - 2005 新規生理活性脂質の生体機能

2004 - 2004 Autotaxinの癌細胞浸潤・転移促進機構の解明とその応用

2003 - 2004 Physiological role of lysophosphatidic acid.

2003 - 2003 がん細胞の転移・浸潤能とリゾホスファチジン酸の関連

2001 - 2002 Mechanism of Iyshosphatidic acid production.

2000 - 2002 リゾホスファチジン酸の生理機能の解明と病態との関連-創薬に向けた基盤研究-

2000 - 2001 神経細胞移動を制御するLIS1カスケードおよびその制御機構の解明

1998 - 2001 Novel functions of phospholipases

1999 - 2000 新規リゾリン脂質性メディエーター"リゾPS"の生体内機能と作用機構の解明

1998 - 2000 Patho-Physiological function of Phosphatidylserine-specific Phospholipase A1-Specific role of PS-PLA 1 in mast cell activation-

1997 - 1999 Biological and pharmaceutical studies on the mechanism of intracellular sorting of cholesterol and vitamin E

1996 - 1999 NEW FUNCTION OF PHOSPHOLIPASE A

1997 - 1998 血小板から分泌されるホスファチジルセリン特異的ホスホリパーゼの構造と機能

1996 - 1998 Production and application of novel model animals with an oxidative stress

1995 - 1997 PAFの脳内機能-PAFアセチルヒドロラーゼによる制御機構の解析-

1995 - 1997 コレステロールのプロトン共役性膜透過機構の解析

1996 - 1996 GPI型NCAMの細胞外放出に関与する新規ホスホリパーゼ

1996 - 1996 PAFの脳内機能-PAFアセチルハイドロラーゼによる制御機構の解析-

1996 - 1996 コレステロールのプロトン共役性膜透過機構の解析

1995 - 1996 Development of Pharmacokinetic and Safety Assessment of in vivo Virus Infection and Vaccine Therapy

1994 - 1996 Basic study for analysis and application of bio-factor which regulate transfer of cholresterol in vivo.

1995 - 1995 血小板活性化因子(PAF)と細胞接着因子

1994 - 1994 ポリオウイルスレセプターは細胞間認識に関与するか?

1992 - 1994 Development of new quality control method for oral live vaccine using transgenic mice susceptible to poliovirus.

1992 - 1994 Biological functions of mammalian non-pacreatic type Phospholipase A_2

1993 - 1993 新しい免疫グロブリンスーパーファミリーに属する膜タンパク質の機能解析

Show all

Papers (475)：

Masumi Oka, Sohta Akaki, Osamu Ohno, Maho Terasaki, Yuho Hamaoka-Tamura, Michiko Saito, Shinichi Kato, Asuka Inoue, Junken Aoki, Kenji Matsuno, et al. Suppression of Mast Cell Activation by GPR35: GPR35 Is a Primary Target of Disodium Cromoglycate. The Journal of pharmacology and experimental therapeutics. 2024. 389. 1. 76-86
Tamaki Izume, Ryo Kawahara, Akiharu Uwamizu, Luying Chen, Shun Yaginuma, Jumpei Omi, Hiroki Kawana, Fengjue Hou, Fumiya K. Sano, Tatsuki Tanaka, et al. Structural basis for lysophosphatidylserine recognition by GPR34. Nature Communications. 2024. 15. 1
Asako Hamu-Tanoue, Koichi Takagi, Yoshitaka Taketomi, Yoshimi Miki, Yasumasa Nishito, Kuniyuki Kano, Junken Aoki, Takahiro Matsuyama, Kiyotaka Kondo, Yoichi Dotake, et al. Group III secreted phospholipase A₂-driven lysophospholipid pathway protects against allergic asthma. The FASEB Journal. 2024. 38. 2
Kota Sato, Yuto Sasaki, Michiko Ohno-Oishi, Kuniyuki Kano, Junken Aoki, Kosuke Ohsawa, Takayuki Doi, Hiroyuki Yamakoshi, Yoshiharu Iwabuchi, Chihiro Kawano, et al. New Dihydropyridine Derivative Attenuates NF-κB Activation via Suppression of Calcium Influx in a Mouse BV-2 Microglial Cell Line. The Tohoku Journal of Experimental Medicine. 2024
Mazin A. S. Abdelwahid, Kosuke Ohsawa, Akiharu Uwamizu, Kuniyuki Kano, Junken Aoki, Takayuki Doi. Synthesis and Biological Evaluation of Lysophosphatidic Acid Analogues Using Conformational Restriction and Bioisosteric Replacement Strategies. ACS Omega. 2023

ｍore...

MISC (652)：

梶谷直人, 梶谷直人, 梶谷直人, 岡田麻美, 井上飛鳥, 朴秀賢, 青木淳賢, 竹林実, 竹林実. Tricyclic antidepressants act as a G protein-biased LPA1 receptor agonist and contribute to antidepressant effects. 日本生物学的精神医学会(Web). 2023. 45th
柳沼舜, 近江純平, 可野邦行, 青木淳賢. PS-PLA₁-LysoPS軸の感染症免疫における機能解析. 脂質生化学研究. 2023. 65
高木博那, 可野邦行, 冬室若菜, 青木淳賢. リゾホスファチジン酸受容体LPA₃作動薬による肺線維症抑制作用メカニズムの解析. 脂質生化学研究. 2023. 65
井上莉那, 可野邦行, 福内友子, 山岡法子, 青木淳賢, 三枝大輔, 三枝大輔. Development of separation method for hexosylceramides by time-of-flight ion mobility mass spectrometry. 質量分析総合討論会講演要旨集. 2023. 71st
柳沼舜, 近江純平, 可野邦行, 青木淳賢. PS-PLA1-LysoPS軸の感染症免疫における機能解析. 日本生化学会大会(Web). 2022. 95th

ｍore...

Professional career (1)：

薬学博士 (The University of Tokyo)

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page