Rchr
J-GLOBAL ID:200901055070756320
Update date: Jan. 31, 2024
Uesugi Motonari
ウエスギ モトナリ | Uesugi Motonari
Affiliation and department:
Homepage URL (1):
http://www.scl.kyoto-u.ac.jp/~uesugi/
Research theme for competitive and other funds (22):
- 2022 - 2025 Chemical biology of cellular self-assemblies
- 2021 - 2023 Designer Melanin for Analyzing and Controlling Cells
- 2019 - 2022 Exploration of Self-Assembling Bioactive Small Molecules
- 2017 - 2022 Chemical signals of synthetic nutrient conjugates
- 2017 - 2022 Frontiers in Chemical Communications
- 2017 - 2019 Synthetic post-translational modifications
- 2014 - 2019 Control and Analysis of Cells by Synthetic Small Molecules
- 2016 - 2018 Creating Chemical Tools that Enable Investigation and Identification of RNA G-Quadruplexes
- 2015 - 2018 Discovery of novel RNA G-quadruplex ligands from a chemical library
- 2015 - 2018 Development of the efficient cardiac differentiation method of pluri-poteint stem cells by using novel chemicals
- 2013 - 2018 Molecular mechanism of ABC proteins involved in cholesterol homeostasis
- 2014 - 2017 Structure and dynamics of intermediate filament proteins
- 2013 - 2017 Elucidation of signals and metabolic bases that regulate functions of plasma membrane microdomains
- 2014 - 2016 脂質関連内因性分子の新機能発掘と調節
- 2014 - 2016 Small molecules that control Hes1 oscillation
- 2011 - 2014 Study on Molecular Mechanism of Cytotoxicity of Marine Natural Products
- 2010 - 2014 Epigenetic plasticity as a novel target for cancer treatment
- 2008 - 2012 Physiological substrates and functions of ABC proteins involved in lipid transport
- 2009 - 2011 小分子有機化合物を起爆剤とした細胞シグナル解析
- 2006 - 2007 Small molecule analysis of cell signaling
- 2006 - 2007 標的タンパク質精製法の開発
- 生命現象分析のための小分子転写因子創成
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Papers (94):
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Fumihiro Kawagoe, Sayuri Mototani, Yasushi Takemoto, Motonari Uesugi, Atsushi Kittaka. Improved and scalable synthesis of potent SREBP inhibitor KK-052 via [3+2] cycloaddition. Synthesis. 2023
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Shao-Hua Zhuo, Naotaka Noda, Kou Hioki, Shuyu Jin, Tomoya Hayashi, Kou Hiraga, Haruka Momose, Wen-Hao Li, Lang Zhao, Takuo Mizukami, et al. Identification of a Self-Assembling Small-Molecule Cancer Vaccine Adjuvant with an Improved Toxicity Profile. Journal of medicinal chemistry. 2023. 66. 18. 13266-13279
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Amelie Perron, Sathi Mandal, Thiago Negrão Chuba, Di Mao, Vaibhav Pal Singh, Naotaka Noda, Russell Tan, Hue Thi Vu, Masahiro Abo, Motonari Uesugi. Small-Molecule Drug Repurposing for Counteracting Phototoxic A2E Aggregation. ACS chemical biology. 2023
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Kamui Tanaka, Akiyo Suda, Motonari Uesugi, Shiroh Futaki, Miki Imanishi. Xanthine derivatives inhibit FTO in an L-ascorbic acid-dependent manner. Chemical communications (Cambridge, England). 2023. 59. 72. 10809-10812
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Fumihiro Kawagoe, Sayuri Mototani, Aileen Mendoza, Yasushi Takemoto, Motonari Uesugi, Atsushi Kittaka. Structure-activity relationship studies on vitamin D-based selective SREBP/SCAP inhibitor KK-052. RSC Medicinal Chemistry. 2023
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Books (6):
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ケミカルバイオロジー化合物集 研究展開のヒント
オーム社 2018 ISBN:9784274507090
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京都大学 アイデアが湧いてくる講義 サイエンスの発想法
祥伝社黄金文庫 2017
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京都大学人気講義 サイエンスの発想法
祥伝社 2014
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ケミカルバイオロジー
共立出版 2008 ISBN:4320056701
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ケミカルバイオロジー PNE 蛋白質 核酸 酵素 2007年10月号増刊
共立出版 2007
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