Rchr
J-GLOBAL ID：200901055639615933
Update date: Apr. 14, 2024
Shirasawa Hiroshi
シラサワ ヒロシ | Shirasawa Hiroshi
Affiliation and department：
Job title：
Professor
Research field (1)：
Virology
Research keywords (2)：
ウイルス 分子生物学 Molecular Biology Cancer Studies
, Molecular Biology Cancer Studies
Research theme for competitive and other funds (37)：
- 2020 - 2023 免疫チェックポイント阻害剤に耐性を示す口腔癌に対する腫瘍溶解ウイルス療法の新戦略
- 2016 - 2019 Development of highly functional molecular target drug that enables clinical practice of malignant melanoma using combined immunotherapy
- 2014 - 2017 Development of oncolytic RNA virus sensitive to ganciclovir
- 2011 - 2014 Development of a molecular-targeting therapeutic agent for cancer therapy using a cancer-targeting liposome coupled with viral proteins
- 2010 - 2012 Establishment of a novel therapeutic approach targeting cancer stem cells of neuroblastoma using onclytic virus
- 2010 - 2012 Cancer-targeted liposome coupled to viral proteins for imaging cancer cells
- 2008 - 2010 Development of oncolytic SIN replicon and the mechanism of tumor-specific replication of SIN
- 2008 - 2010 The effect of cancer-targeted liposome with viral proteins on staining and visualizing cancer cells
- 2007 - 2009 Development of cancer-targeted liposome with viral proteins
- 2004 - 2006 RNAウイルスを用いた神経芽腫に対する腫瘍融解ウイルス療法の検討
- 2003 - 2005 新しい癌抑制遺伝子RUNX3発現ベクターによる膵癌治療の試み
- 2003 - 2004 唾液腺組織のcDNAライブラリー作成と唾液腺疾患用DNAチップの開発作製
- 2003 - 2004 アデノウイルスベクターを用いた神経伸長因子遺伝子導入による鼻粘膜嗅上皮の再生
- 2003 - 2004 Gene profiling in adenoid cystic carcinoma cells using in-house cDNA microaray
- 2003 - 2004 Search for oral cancer specific genes and molecular cloning using in-house cDNA microaray
- 2002 - 2004 The analysis of a novel gene E6DG1 function involving in anchorage dependency
- 2002 - 2003 GENETIC PREDISPOSITION IN COPD
- 2000 - 2003 Identification of androgen-independent progression-relate gene and its clinical application for gene therapy in the prostate cancer
- 2001 - 2002 Adencviral vector-mediatedin vivogene transfer of neurotropnins for experimental spinal cord injury in rats
- 2000 - 2002 DPC4/Smad4 Expression Adenovirus Vector for Pancreas Cancer Therapy
- 2000 - 2001 GENETIC PREDISPOSITION AND ENVIRONMENTAL FACTORS IN COPD
- 1999 - 2001 Isolation of a novel tumor suppressor gene on the Chromosome 7 associated with oral squamous cell carcinoma.
- 1999 - 2001 Isolation of a novel tumor suppressor gene on the Chromosome 11 associated with oral squamous cell carcinoma.
- 1998 - 2000 Isolation of a novel tumor suppressor gene on the chromosome 13q14 associated with metastasis of oral cancer
- 1998 - 1999 アデノウィルスベクターをもちいた鼻粘膜へのサイトカイン遺伝子導入に関する研究
- 1998 - 1999 Cloning of the megakaryoblastic leukemia-associated gene located on chromosome 17P13
- 1997 - 1999 p16 Expression Adenovirus Vector for Esophageal and Pancreas Cancer Therapy.
- 1997 - 1998 PCP(フェンシクリジン)投与により発現誘導される遺伝子cDNAのクローニング
- 1996 - 1997 Analysis of a novel gene RA3, expression of which is upregulated during cell proliferation
- 1994 - 1995 Effects of CSF from schisophrenic patients on growth and differentiation of neurobl a stoma cells
- 1994 - 1995 xpression, regulation and poly morphism of the uxil geuls
- 1993 - 1994 ヒトパピローマウイルス16型E6、E6*I遺伝子による転写制御機構の解明
- 1992 - 1993 Effect of forced N-myc gene expression on src gene expression in neuroblastoma cells
- 1989 - 1990 Detection of Human Papillomavirus in Head and Neck Tumors using DNA-hybridization and Immunochemical Aanalysis.
- 1989 - 1990 Elucidation of Mechanisms of HPV Carcinogenesis in Cervical Cancer
- Cloning of cellular genes regulated by human papilloma virus type 16 E6 protein
- ヒトパピローマウイルス16型E6蛋白質が転写調節する宿主遺伝子のクローニング
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Papers (79)：
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XUE MA, TOMOKO OGAWA, ZHENG TIAN, RUIRONG YI, KANG TANG, KENGO SAITO, SARA YATABE, YOSHIFUMI OHNO, RYOSUKE MUROYAMA, EIJI IDO, et al. PKR-NF-κB Pathway Upstream of IFN-β Induction Is Dysregulated in Oncolytic Sindbis Virus-infected HeLa Cells. Anticancer Research. 2023. 43. 7. 2923-2932
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YOSHIFUMI OHNO, RUIRONG YI, AKIKO SUGANAMI, YUTAKA TAMURA, AKIO MATSUMOTO, SHOJI MATSUMOTO, KENGO SAITO, HIROSHI SHIRASAWA. CCL299, a Benzimidazole Derivative Induces G1 Phase Arrest and Apoptosis in Cancer Cells. Anticancer Research. 2021. 41. 2. 699-706
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Ruirong Yi, Yoshifumi Ohno, Zheng Tian, Shuhan Guo, Weiwei Chen, Xue Ma, Nan Win, Qisen Li, Majid Vahed, Kengo Saito, et al. CCL113, a novel sulfonamide, induces selective mitotic arrest and apoptosis in HeLa and HepG2 cells. Oncology Reports. 2020. 44. 6. 2770-2782
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Eriko Y. Saito, Kengo Saito, Tomoro Hishiki, Ayako Takenouchi, Takeshi Saito, Yoshiharu Sato, Keita Terui, Tadashi Matsunaga, Hiroshi Shirasawa, Hideo Yoshida. Sindbis viral structural protein cytotoxicity on human neuroblastoma cells. Pediatric Surgery International. 2020. 36. 10. 1173-1180
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Eriko Y Saito, Kengo Saito, Tomoro Hishiki, Ayako Takenouchi, Takeshi Saito, Yoshiharu Sato, Keita Terui, Tadashi Matsunaga, Hiroshi Shirasawa, Hideo Yoshida. Sindbis viral structural protein cytotoxicity on human neuroblastoma cells. Pediatric surgery international. 2020. 36. 10. 1173-1180
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MISC (274)：
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大野 吉史, 蟻 瑞栄, 馬 雪, 菅波 晃子, 田村 裕, 松本 祥治, 齋藤 謙悟, 白澤 浩. ベンゾイミダゾール誘導体CCL299は細胞周期をG1期で停止させ癌細胞にアポトーシスを誘導する(CCL299, a benzimidazole derivative, induces G1 phase arrest and apoptosis in human cancer cells). 日本癌学会総会記事. 2019. 78回. P-3346
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齋藤 謙悟, 大野 吉史, Vahed Majid, 李 斉森, 郭 書翰, 馬 雪, 菅波 晃子, 田村 裕, 荒井 孝義, 白澤 浩. 新規フェニル化合物CCL360、CCL361によるG2/M期停止とアポトーシス誘導(G2/M phase arrest and apoptosis induced by novel phenyl compounds, CCL360 and CCL361). 日本癌学会総会記事. 2018. 77回. 621-621
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坪坂 歩, 大野 吉史, 李 斉森, 馬 雪, 郭 書翰, 蟻 瑞栄, 中本 晋吾, 齋藤 謙悟, 菅波 晃子, 田村 裕, et al. 新規化合物CCL441は細胞周期をG2/M期で停止させアポトーシスを誘導する. 日本癌学会総会記事. 2017. 76回. P-3356
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大野 吉史, 蟻 瑞栄, 陳 偉巍, 田 錚, 郭 書翰, 李 斉森, 馬 雪, 菅波 晃子, 田村 裕, 松本 明郎, et al. ベンゾイミダゾール誘導体C299-1による癌細胞傷害機序の解析. 日本癌学会総会記事. 2016. 75回. P-1391
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坪坂 歩, 蟻 瑞栄, 大野 吉史, 陳 偉巍, 田 錚, 郭 書翰, 李 斉森, 馬 雪, 菅波 晃子, 齋藤 謙悟, et al. 新規化合物CCL-113はM期とエンドサイクルを誘導する. 日本癌学会総会記事. 2016. 75回. P-2372
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Works (2)：
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Immortalization of human keratinocytes
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ヒト角化上皮細胞の不死化機構
Professional career (1)：
- (BLANK) (Chiba University)
Association Membership(s) (6)：
American Society for Virology
, American Society for Microbiology
, 分子生物学会
, 日本産科婦人科学会
, 日本癌学会
, 日本ウイルス学会
