Rchr
J-GLOBAL ID：200901055874377900   Update date: Apr. 03, 2024

Unoki Motoko

ウノキ モトコ | Unoki Motoko
Affiliation and department：
The University of Tokyo Graduate School of Medicine Department of Human Genetics

About The University of Tokyo Graduate School of Medicine Department of Human Genetics


Job title： Associate Professor
Homepage URL  (2)： http://www.humgenet.m.u-tokyo.ac.jp/index.html ,  http://www.humgenet.m.u-tokyo.ac.jp/index.en.html
Research field  (6)： Developmental biology ,  Genetics ,  Medical biochemistry ,  Tumor biology ,  Cell biology ,  Molecular biology
Research keywords  (14)： non-homologous end joining ,  HELLS ,  CDCA7 ,  DNA repair ,  methylation ,  Hydroxylysine ,  acetylation ,  ICF syndrome ,  hydroxylation ,  UHRF1 ,  Histone modification ,  DNA methylation ,  Epigenetics ,  Carcinogenesis
Research theme for competitive and other funds  (22)：
  • 2023 - 2027 長鎖シークエンス技術を用いた腫瘍の転写産物全長の解析
  • 2023 - 2026 哺乳類におけるペリセントロメア非コードRNAを介した新しいDNAメチル化機構の解明
  • 2019 - 2024 Mechanisms underlying maintenance of genome integrity by DNA methylation
  • 2023 - 2024 Support for start-up research funding for female faculty members at the University of Tokyo in FY2023
  • 2019 - 2020 セントロメア・ペリセントロメア反復配列の新たなDNAメチル化維持機構
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Papers (51)：
  • Kugui Yoshida-Tanaka, Ko Ikemoto, Ryoji Kuribayashi, Motoko Unoki, Takako Takano, Akihiro Fujimoto. Long-read sequencing reveals the complex structure of extra dic(21;21) chromosome and its biological effects. Human Genetics. 2023. 142. 9. 1375-1384
  • Shuhei Uemura, Shoji Maenohara, Kimiko Inoue, Narumi Ogonuki, Shogo Matoba, Atsuo Ogura, Mayuko Kurumizaka, Kazuo Yamagata, Jafar Sharif, Haruhiko Koseki, et al. UHRF1 is essential for proper cytoplasmic architecture and function of mouse oocytes and derived embryos. Life Science Alliance. 2023. 6. 8. e202301904-e202301904
  • Motoko Unoki, Guillaume Velasco, Satomi Kori, Kyohei Arita, Yasukazu Daigaku, Wan Kin Au Yeung, Akihiro Fujimoto, Hirofumi Ohashi, Takeo Kubota, Kunio Miyake, Hiroyuki Sasaki. Novel compound heterozygous mutations in UHRF1 are associated with atypical immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome with distinctive genome-wide DNA hypomethylation. Human Molecular Genetics. 2023. 32. 9. 1439-1456
  • Unoki M, Sasaki H. The UHRF protein family in epigenetics, development, and carcinogenesis. Proceedings of the Japan Academy. Series B, Physical and biological sciences. 2022. 98. 8. 401-415
  • Naoki Haratake, Qingjiang Hu, Tatsuro Okamoto, Tomoko Jogo, Gouji Toyokawa, Fumihiko Kinoshita, Tomoyoshi Takenaka, Tetsuzo Tagawa, Norifumi Iseda, Shinji Itoh, et al. Identification of SLC38A7 as a Prognostic Marker and Potential Therapeutic Target of Lung Squamous Cell Carcinoma. Annals of surgery. 2021. 274. 3. 500-507
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MISC (10)：
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Books (18)：
  • 疾患原因遺伝子・タンパク質の解析技術と創薬/診断技術への応用
    技術情報協会 2022 ISBN:9784861048777
  • ゲノム・エピゲノムインテグリティーを守護する蛋白質 -ICF症候群研究から見えてきたCDCA7/HELLSクロマチンリモデリング 複合体の役割-
    ニューサイエンス社 月刊「細胞」 8月号 2021
  • エピゲノムで新たな解明が進む「先天性疾患」
    メディカルドゥ 2021 ISBN:9784909508119
  • Understand better the Epigenetics!
    2020 ISBN:9784758122078
  • Recent insights into the chromatin remodeling and chromosome stability from studies of ICF syndrome
    2020
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Lectures and oral presentations  (137)：
  • 三毛猫の毛色をつかさどる遺伝子の探索 〜60年間の謎に挑む〜
    (コンパニオンアニマルのゲノム医療研究会 第4回研究会 2024)
  • DNA methylation safeguards genome stability: Insights from ICF syndrome studies
    (The 46th Annual Meeting of the Molecular Biology Society of Japan 2023)
  • Molecular pathogenesis underlying genetic diseases with aberrant DNA methylation
    (Human Genetics Asia 2023 (68th Annual Meeting of the Japan Society of Human Genetics) 2023)
  • Maintenance DNA methylation and chromosome stability: Insights from ICF syndrome studies
    (The 2nd International Symposium on replication of non genome "Cutting Edge of Epigenetics" 2023)
  • Analyses of novel compound heterozygous mutations in UHRF1 identified in a patient with atypical ICF syndrome
    (The 16th Annual Meeting of the Japanese Society for Epigenetics 2023)
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Education (1)：
  • 1999 - 2003 The University of Tokyo Graduate School of Medicine Pathology, Immunology, Microbiology,
Professional career (1)：
  • Ph.D. (The University of Tokyo)
Work history (7)：
  • 2022/09 - 現在 The University of Tokyo Department of Human Genetics Associate Professor
  • 2019/09 - 2022/08 Medical Institute of Bioregulation, Kyushu University Division of Epigenomics and Development, Associate professor
  • 2010/10 - 2019/08 Kyushu University Epigenomics and development Assistant Professor
  • 2008/05 - 2010/09 RIKEN Postdoctoral fellow
  • 2004/05 - 2008/04 National Cancer Institute (NIH) Postdoctoral fellow
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Committee career (11)：
  • 2024/01 - 現在 The Japan Society of Human Genetics Members of the Research Promotion Committee
  • 2023/06 - 現在 東京大学 疾患生命工学センター動物実験施設運営小委員会委員
  • 2023/04 - 現在 Genes & Genetic Systems Editorial Board
  • 2023/04 - 現在 東京大学 医学部動物実験委員会委員
  • 2015/05 - 現在 Kyushu University Board member of Kyushu University Specially Certified Committee for Regenerative Medicine
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Awards (4)：
  • 2015/09 - 内藤記念科学振興財団 The 40th Naito Conference Best poster award
  • 2013/08 - 第25回高遠シンポジウム優秀ポスター賞
  • 1999/03 - 日本獣医師会 日本獣医師会賞
  • 1994/03 - 竹岸・越智賞
Association Membership(s) (6)：
The Japan Society of Human Genetics ,  The molecular biology society of Japan ,  The Genetics Society of Japan ,  The Japanese Society for Epigenetics ,  American Association for Cancer Research ,  Japanese Cancer Association
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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