Rchr
J-GLOBAL ID:200901056262877020
Update date: Jan. 31, 2024
Miyoshi Hideto
ミヨシ ヒデト | Miyoshi Hideto
Affiliation and department:
Research field (1):
Bioorganic chemistry
Research keywords (13):
bioenergetics
, inhibitor of respiratory enzymes
, complex I
, カルジオリピン
, ユビキノン
, ミトコンドリア
, 呼吸鎖酵素
, 生物有機化学
, Caldiolipin
, Structure-Activity relation
, Ubiquinone
, Respiratory Inhibitor
, Respiratory Enzyme
Research theme for competitive and other funds (32):
- 2021 - 2024 Construct of the platform for developing antibiotics targeting Vibrio cholera NADH-ubiquinone oxidoreductase
- 2020 - 2023 藻類バイオマス開発のための嫌気的代謝スイッチング制御メカニズムの解明
- 2019 - 2021 Production of chemicals that suppress generation of ROS from mitochondrial respiratory chain.
- 2018 - 2021 Elucidation of inhibitor-resistance mechanism of Na+-pumping NADH-ubiquinone oxidoreductase from Vibrio cholera
- 2017 - 2020 Analysis of lipid transfer mechanism and organelle interactions required for multifunction of lipids
- 2016 - 2018 Conversion of mitochondrial respiratory complex I to a light-driven proton pump by chemical modification
- 2014 - 2017 Site-specific modification of respiratory complex I for single molecule analysis
- 2011 - 2014 Study on the function of ND1 subunit, a key subunit of respiratory complex I
- 2010 - 2013 Synthetic study of novel antitumor agents
- 2011 - 2012 Probing the intercellular traffic mechanism of ubiquinone using synthetic molecular probes
- 2010 - 2011 Development of conductive quinone-modified Au-electrode enabling super-sensitive detection of the activities of mitochondrial respiratory enzymes
- 2008 - 2010 Exploring the function of membrane domain of mitochondrial complex-I on the basis of synthesis of inhibitor probes
- 2006 - 2007 ミトコンドリア複合体-I活性の光制御をめざした光応答性阻害剤の合成開発
- 2005 - 2007 低酸素適応における寄生虫ミトコンドリア特異的呼吸酵素群の生理機能
- 2005 - 2006 Study on respiratory enzyme complex I based on the organic synthesis of acetogenin analogues
- 2004 - 2005 呼吸鎖酵素のピンポイント電子移動観測を実現する導電性阻害剤修飾電極の開発
- 2002 - 2005 Molecular organization and physiological functions of the respiratory chain specific for mitochondria from Plasmodium
- 2003 - 2004 Synthesis of functional probes toward elucidation of the function of respiratory enzymes of Caenorhabditis elegans.
- 2001 - 2004 Physiological function of respiratory enzymes specific for parasite mitochondria in the adaptation to low oxygen tension
- 2001 - 2002 マラリア原虫ミトコンドリア特異的呼吸酵素群の分子構築と生理機能
- 2000 - 2001 Molecular Mechanism and Structural Basis of Ubiquinone-Redox Reaction in Bacterial Respiratory Chains
- 1999 - 2000 Study on ubiquinol reaction site of cytochrome bo in Escherichia coli.
- 1997 - 1999 Structure and Function of Quinoprotein Dehydrogenase
- 1998 - 1998 呼吸鎖金属酵素における共鳴ラマン測定のための^<13>C-標識ユビキノン類の有機合成
- 1996 - 1997 Probing the ubiquinol oxidatiousite of Eschenchia col ubiquinol oxidases.
- 1995 - 1996 DEVELOPMENT OF TERMINAL OXIDASE-SPECIFIC BACTERIOCIDES AND BIOCHEMICAL ANALYSIS OF THE SUBSTRATE OXIDATION MECHANISM
- 1994 - 1995 Study on structure of cytochrome b using antimycin A-resistant mutants.
- 1993 - 1994 Development of new classes of flower inducing compounds and their mechanism of action.
- 1991 - 1991 シトクロムbcl複合体及び光合成系IIにおけるキノン結合部位の三次元構造の研究
- 1987 - 1987 ミトコンドリアにおける酸化的リン酸化脱共役剤の作用機構に関する研究
- 種々の電子伝達阻害剤の構造活性相関と作用機構の解明
- Structure-activity studies of Various electron-transfer inhibitors and mode of action studies.
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Papers (221):
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Ryo Ikunishi, Ryohei Otani, Takahiro Masuya, Kyoko Shinzawa-Itoh, Tomoo Shiba, Masatoshi Murai, Hideto Miyoshi. Respiratory complex I in mitochondrial membrane catalyzes oversized ubiquinones. Journal of Biological Chemistry. 2023. 105001-105001
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Atsuhito Tsuji, Takahiro Masuya, Norihito Arichi, Shinsuke Inuki, Masatoshi Murai, Hideto Miyoshi, Hiroaki Ohno. Discovery of Bis-sulfonamides as Novel Inhibitors of Mitochondrial NADH-Quinone Oxidoreductase (Complex I). ACS Medicinal Chemistry Letters. 2023. 14. 2. 211-216
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Jun-ichi Kishikawa, Moe Ishikawa, Takahiro Masuya, Masatoshi Murai, Yuki Kitazumi, Nicole L. Butler, Takayuki Kato, Blanca Barquera, Hideto Miyoshi. Cryo-EM structures of Na+-pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae. Nature Communications. 2022. 13. 1
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Shinpei Uno, Takahiro Masuya, Oleksii Zdorevskyi, Ryou Ikunishi, Kyoko Shinzawa-Itoh, Jonathan Lasham, Vivek Sharma, Masatoshi Murai, Hideto Miyoshi. Diverse reaction behaviors of artificial ubiquinones in mitochondrial respiratory complex I. Journal of Biological Chemistry. 2022. 102075-102075
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Daniel N. Grba, James N. Blaza, Hannah R. Bridges, Ahmed-Noor A. Agip, Zhan Yin, Masatoshi Murai, Hideto Miyoshi, Judy Hirst. Cryo-electron microscopy reveals how acetogenins inhibit mitochondrial respiratory complex I. Journal of Biological Chemistry. 2022. 298. 3. 101602-101602
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MISC (214):
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安部真人, 千ヶ崎修平, 奥公秀, 阪井康能, 三芳秀人. 合成リゾカルジオリピン類縁体のトランスアシラーゼtafazzinに対する阻害効果. 脂質生化学研究. 2019. 61
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安部真人, 澤田良樹, 奥公秀, 阪井康能, 三芳秀人. ミトコンドリア膜リン脂質カルジオリピンのリモデリング機構. 脂質生化学研究. 2018. 60. 84
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安部真人, 澤田良樹, 宇野晋平, 千ヶ崎修平, 奥公秀, 阪井康能, 三芳秀人. 酵母tafazzinによるカルジオリピンのリモデリング反応の基質特異性. 日本農芸化学会大会講演要旨集(Web). 2018. 2018. ROMBUNNO.3A14a08 (WEB ONLY)
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山下哲生, 稲岡健ダニエル, 志波智生, 三芳秀人, 原田繁春, 北潔, 平野勝也. 競合および混合阻害剤との共結晶構造解析により明らかとなった酵母由来Type II NADH脱水素酵素のユビキノン結合部位. 日本農芸化学会中四国支部講演会講演要旨集(Web). 2018. 51st
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山下哲生, 稲岡健ダニエル, 稲岡健ダニエル, 志波智生, 大橋拓未, 岩田想, 岩田想, 岩田想, 岩田想, 矢木隆雄, et al. 新規競合阻害剤および混合型阻害剤との共結晶構造解析による酵母Type II NADH脱水素酵素Ndi1におけるユビキノン結合部位の同定. 日本生化学会大会(Web). 2018. 91st
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Education (4):
- - 1986 Kyoto University
- - 1986 Kyoto University Graduate School, Division of Agriculture
- - 1982 Okayama University Faculty of Agriculture
- - 1982 Okayama University Faculty of Agriculture
Professional career (1):
Committee career (13):
- 2017/04/01 - 2019/03/31 Pesticide Science Society of Japan President
- 2015/04/01 - 2017/03/31 Pesticide Science Socirty of Japan -
- 2013/04/01 - 2017/03/31 Pesticide Science Socirty of Japan -
- 2011/04/01 - 2015/03/31 Japan Society for Bioscience, Biotechnology, and Agrochemistry -
- 2005 - 2012 Pesticide Science Socirty of Japan -
- 2010 - 2010 - -
- 2010 - 2010 - -
- 2010 - 2010 - -
- 2009 - 2009 - -
- 2009 - 2009 - -
- 2008 - 2008 - -
- 2008 - 2008 - -
- 2001 - 2003 日本農薬学会 評議員
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Awards (4):
- 2005 - 日本農薬学会業績賞
- 2005 - Society Awards on Prominent Achievement (Pesticide Science Society of Japan, 2005)
- 1998 - 日本農芸化学会奨励賞
- 1998 - Award for The Encouragement of Young Scientists (The Japan Society for Bioscience, Biotechnology and Agrochemistry, 1998)
Association Membership(s) (6):
Pesticide Science Society of Japan
, The Japanese Biochemical Society
, Japan Society for Bioscience, Biotechnology, and Agrochemistry
, 日本農薬学会
, 日本生化学会
, 日本農芸化学会
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