Research field (4)：
Anatomy
, Oral medicine (pathology)
, Anatomy
, Oral medicine
Research keywords (4)：
機能系基礎歯科学
, 形態系基礎歯科学
, Functional Basic Dentistry
, Oral Anatomy and Morphological Basic Dentistry
Research theme for competitive and other funds (48)：
2018 - 2021 Elucidation of a novel regulatory mechanism of bone metabolism by cellular senescence regulators and its therapeutic application
2018 - 2021 Osteoblast-specific cell-surface antigen regulating recruitment of osteoclasts: Bone regeneration based on the new concept concerning the regulation of bone remodeling
2015 - 2018 Roles of bone metastatic mammary tumor cell-derived extracellular vesicles in osteoclast differentiation and function
2015 - 2018 Novel function of osteoclastogenesis and bone resorption by membrane trafficking regulatory molecule
2015 - 2017 Development of novel methods to regulate only papthologically activated osteoclasts: A novel Concept for the Osteoclast Activation
2014 - 2016 Osteoclastogenesis from embryonic macrophages: Novel cell fate analysis and regulation of bone metabolism
2012 - 2016 Screening for regulatory proteins of osteoclastogenesis with lentiviral shRNA library
2013 - 2015 Regulation of pathological bone destruction via transmembrane immune regulator Tim-3
2012 - 2014 Regulation of bone resorption by membrane reparing molecules: Live imaging of the specific fusion among osteoclast precursors
2011 - 2011 Expression of WT1 natural ant-sense NA and osteoclastogenesis : A novel strategy for the regulation of bone destruction
2009 - 2011 Regulation of bone destruction by bone marrow mesenchymal stem cells : Development and application of the cell-surface marker specific to tissue stem cells
2009 - 2011 Regulation of inflammatory bone destruction by galectin 3 : Identification of the novel receptor and molecular histological research
2009 - 2011 Analysis of regulatory mechanism of bone destruction and inflammation in experimental periodontitis mediated by IL-27 receptor
2007 - 2008 Molecular Immunological and Morphological Analysis of Novel Cell-surface Molecules Regulating Bone Resorption
2007 - 2008 Analysis of the regulation of bone resorption and signaling by membrane proteins expressed in osteoclasts
2005 - 2006 Expression of OCZF directed by the cathepsin K promoter affects bone mass and osteoclast formation in Transgenic Mice.
2004 - 2006 Regulation of osteoclastogenesis by a novel surface membrane receptor-like molecule : Preparation of gene-deficient mice and molecular histological analysis
2003 - 2005 破骨細胞死の制御機構:RNAi法を用いた分子細胞生物学的解析
2003 - 2004 Control of osteoclast differentiation by using siRNA for ICAM-1 gene silencing
2003 - 2004 破骨細胞死の制御機構:RNAi法を用いた分子細胞生物学的解析
2003 - 2004 Preparation of knockout Mouse of a transregulatory fector, OCZF which is specifically expressed inosteoclasts
2002 - 2003 Osteoclast Differentiation initiated at late-stage of mitosisof progenitor cells : Molecular mechanism of divergence from cell cycle
2002 - 2003 Molecular mechanisms of bone formation and absorption in the ankle joint of adjuvant arthritic rats
2001 - 2002 Functional analysis of transcriptional regulator induced by ODF in the signal transduction of formation and activation of osteoclasts
2001 - 2001 POZ-Znフィンガー型転写制御因子の細胞増殖抑制作用の解析
2000 - 2001 Novel cell surface Fusion Regulartory Molecule involved in osteoclastogenesis: Morphological analysis of precursor fusion
1999 - 2000 Role of a novel Zn finger transcriptional regulator involved in osteoclastogenesis
1999 - 2000 Nerve growth factor, Its role in regulation of an abnormal bone remodeling in local inflammation.
1997 - 1998 Molecular analysis of the signal transducers expressed in the process of the differentiation into osteoclasts
1997 - 1998 Mechanism of cell-cell fusion process specific for preosteoclasts : Establishment of precursor cell line and morphological & cell biological studies on the cell fusion.
Differentiation and Activation of the Osteoclasts / Cell Biological Research
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Papers (75)：
Norihisa Uehara, Shibusawa N, Mikami Y, Kyumoto-Nakamura Y, Sonoda S, Kato H, Yamaza T, Kukita T. Bone metastatic mammary tumor cell-derived extracellular vesicles inhibit osteoblast maturation via JNK signaling. Archives of biochemistry and biophysics. 2023
Masatoshi Murayama, Hirohito Hirata, Makoto Shiraki, Juan L Iovanna, Takayoshi Yamaza, Toshio Kukita, Toshihisa Komori, Takeshi Moriishi, Masaya Ueno, Tadatsugu Morimoto, et al. Nupr1 deficiency downregulates HtrA1, enhances SMAD1 signaling, and suppresses age-related bone loss in male mice. Journal of cellular physiology. 2023. 238. 3. 566-581
Hirohito Hirata, Asana Kamohara, Masatoshi Murayama, Kenichi Nishioka, Hiroaki Honda, Yasuteru Urano, Hidenobu Soejima, Shinya Oki, Toshio Kukita, Shunsuke Kawano, et al. A novel role of helix-loop-helix transcriptional factor Bhlhe40 in osteoclast activation. Journal of cellular physiology. 2022. 237. 10. 3912-3926
Xianghe Xu, Takeo Shobuike, Makoto Shiraki, Asana Kamohara, Hirohito Hirata, Masatoshi Murayama, Daisuke Mawatari, Masaya Ueno, Tadatsugu Morimoto, Toshio Kukita, et al. Leukemia/lymphoma-related factor (LRF) or osteoclast zinc finger protein (OCZF) overexpression promotes osteoclast survival by increasing Bcl-xl mRNA: A novel regulatory mechanism mediated by the RNA binding protein SAM68. Laboratory investigation; a journal of technical methods and pathology. 2022. 102. 9. 1000-1010
Membrane Nanotube Formation in Osteoclastogenesis
Ed. Kurt Pfannkuche, Human Press 2015
Involvement of Deoxyadenosine and Adnosine Deaminase in the Methotrexate-Induced Suppression of Inflammatory Bone Destruction
Ed. Kasandra Warrick, Nova Science Publishers 2015
The new aspect of calcitonin escape phenomenon: A possible involvement of osteoclast differentiation antigen in the regulation of osteoclastogenesis and function of calcitonin receptor
Managing Editor: S.G. PANDALAI, Transworld Research Network 2001
破骨細胞の特異的抗原
Bone Science 講座 「骨形成と骨吸収及びそれらの調節因子」 広川書店 1995
Osteoclast Specific Antigen
Bone Science Lecture "Signaling of Bone Formation and Bone Resorption: Basis for Bone Diseases. 1995
Education (4)：
- 1980 Kyushu University
- 1980 Kyushu University Graduate School, Division of Agriculture
- 1978 Kyushu University School of Agriculture
- 1978 Kyushu University Faculty of Agriculture
Professional career (3)：
(BLANK)
(BLANK)
Doctor of Dental Science
Work history (4)：
1987 - 1989 Development of Human Bone Marrow Culture System
(Professor David Roodman)
(University of Texas, Faculty of Medicine, San Antonio, TX, USA)
for Forming Osteoclast-like Cells.
Committee career (2)：
2018/07 - 2021/06 Laboratory Investigation (An official journal of the United States and Canadian Academy of Pathology) Editorial Boad
Japanese Association for Oral Biology councilor
Awards (2)：
1995 - 歯科基礎医学会賞
1995 - Award of Japanese Association for Oral Biology
Association Membership(s) (9)：
日本生化学会
, 日本骨代謝学会
, アメリカ骨代謝学会(American Society of Bone and Mineral Research)
, 歯科基礎医学会
, 日本解剖学会
, Japanese Association of Anatomists
, Japanese Society for Bone and Mineral Research
, American Society for Bone and Mineral Research
, Japanese Association for Oral Biology
