Rchr

J-GLOBAL ID：200901056752945156 Update date: Feb. 01, 2024

Hotokezaka Hitoshi

ホトケザカヒトシ | Hotokezaka Hitoshi

Affiliation and department：
Job title：准教授

Research field (2)： Oral medicine , Developmental dentistry

Research keywords (2)：歯科矯正学 , orthodontics

Research theme for competitive and other funds (33)：

2023 - 2026 歯根吸収発症における細胞小器官分解システム関連蛋白の役割
2023 - 2026 変異型Rufy4を発現する破骨細胞の細胞外小胞を介した骨吸収調節機構の解明と応用
2022 - 2025 オーラルフレイルが全身に及ぼす影響の解明:動物モデルの行動学的・分子生物学的解析
2021 - 2024 口腔がんの進展・転移における低酸素環境下でのcPLA2の働き
2020 - 2023 歯根吸収抑制におけるcPLA2の役割-硝子様変性と破歯細胞活性を標的にして-

2019 - 2022 硝子様変性と破歯細胞活性を標的にしたHIF-1α阻害による歯根吸収抑制機構の解明

2018 - 2022 Effect of neuropeptide oxytocin on osteoclast and orthodontic tooth movement

2018 - 2022 分子イメージングを用いて力と骨代謝の関係を究明し矯正力を最適化する

2018 - 2021 低用量ピル(エストロゲンおよびプロゲステロン)は矯正力による歯の移動を妨げるか?

2018 - 2021 神経ペプチド・オキシトシンが破骨細胞および矯正学的歯の移動に与える影響の解明

2018 - 2021 分子イメージングを用いて力と骨代謝の関係を究明し矯正力を最適化する

2017 - 2020 歯根吸収発症における細胞内小器官分解機構を有する12/15-LOXの関与

2012 - 2016 A trial study to acceleration of orthodontic tooth movement by low intensity pulsed ultrasound

2012 - 2016 高血糖ハイリスクの歯根吸収への影響

2012 - 2015 SHIPノックアウトマウスを用いたメカニカルストレス誘導骨代謝に関する研究

2010 - 2012 細胞生物学的特性を示すセリシン含有セメントは創傷治癒効果を有する

2009 - 2012 アポトーシス阻害剤による歯根吸収の抑制効果の検討

2008 - 2010 DAG lipase-lipoxygenase pathway in Ca sensing of parathyroid cells

2007 - 2008 A study for recalcification of pathological root resorption

2005 - 2007 Lipid mediators on the extracellular Ca^<2+>-sensing in parathyroid cells

2002 - 2005 病的歯根吸収と破歯細胞のシグナル伝達

2005 - 破骨細胞分化の細胞融合因子の探索

2005 - 矯正力による歯の移動と歯根吸収

2005 - Orthodontically induced tooth movement and root resorption

2003 - 2004 Regulation of pathologic root resorption by control of MAPK signaling

2002 - 2004 Intracellular transduction mechanism on the extracellular Ca^<2+>-sensing in parathyroid cells

2001 - 2002 The effect of stress proteins that induce proinflammatory cytokines on pathological root resorption.

2000 - 2002 ストレスタンパク質の歯周病及び病的歯根吸収に及ぼす影響

2000 - 2002 Effect of Stress Proteins on Periodontitis and root resorption

1996 - 1998 The development of monitoring system of root resorption during ortodontic treatment

1997 - 1997 抗歯根抗体Fab断片を用いた破歯細胞の歯根面接着阻害による歯根吸収予防法の開発

1996 - 1996 破歯細胞の歯根面接着阻害による歯根吸収予防法の開発

1992 - 1992 歯根吸収の分子機構に関する研究-矯正治療時における歯根吸収の術前診断法の開発-

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Papers (22)：

Takuya Nakamura, Yuka Hotokezaka, Carmen Karadeniz, Hitoshi Hotokezaka, Yuika Ueda-Ichinose, Kie Nishioka-Sakamoto, Noriaki Yoshida. Early-stage periodontal ligament compression predicts orthodontically induced root resorption in rats. The Angle Orthodontist. 2023
Kie Nishioka-Sakamoto, Hitoshi Hotokezaka, Yuka Hotokezaka, Yukako Nashiro, Mariko Funaki, Seigo Ohba, Noriaki Yoshida. Fixation of an orthodontic anchor screw using beta-tricalcium phosphate in a screw-loosening model in rats. The Angle Orthodontist. 2023. 93. 3. 341-347
佛坂斉祉, 森石武史, 佛坂由可. リチウムは虚血性細胞死、硝子様変性および破歯細胞出現を抑制することで矯正力による歯根吸収を減少させる(Lithium reduces orthodontic root resorption by suppressing ischemic cell death, hyalinization, and odontoclasts formation in rats). Journal of Oral Biosciences Supplement. 2022. 2022. 334-334
Keira Arizono-Shimada, Hitoshi Hotokezaka, Yukiko Morita, Airi Ino-Kondo, Yuika Ueda-Ichinose, Yukako Nashiro, Yuka Hotokezaka, Keiko Yoshimi, Stavros Kiliaridis, Noriaki Yoshida. The effect of masseter muscle mass on the rate of experimental tooth movement in rats. Journal of Oral Rehabilitation. 2022. 49. 10. 1012-1019
Yuika Ueda-Ichinose, Hitoshi Hotokezaka, Toshihiro Miyazaki, Takeshi Moriishi, Yuka Hotokezaka, Keira Arizono, Takuya Nakamura, Noriaki Yoshida. Lithium reduces orthodontically induced root resorption by suppressing cell death, hyalinization, and odontoclast formation in rats. The Angle orthodontist. 2022. 92. 4. 547-554

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MISC (134)：

Tajima, Takako, Hotokezaka, Hitoshi, Yoshida, Noriaki. A deepbite case with bilateral severe posterior scissors and bilaterally impacted mandibular second molars treated with an orthodontic anchor screw. Clinical and Investigative Orthodontics. 2023. 82. 2. 73-79
佛坂斉祉, 森石武史, 佛坂由可. Lithium reduces orthodontic root resorption by suppressing ischemic cell death, hyalinization, and odontoclasts formation in rats. Journal of Oral Biosciences Supplement (Web). 2022. 2022
名城友香子, 有薗ケイラ, 佛坂斉祉, 森田幸子, 井野(近藤)愛理, 上田悠依華, 佛坂由可, 吉見圭子, STAVROS Kiliaridis, 吉田教明. Correlation between tooth movement and masseter volume by injection of botulinum toxin type A. 日本矯正歯科学会大会プログラム・抄録集. 2022. 81st
一瀬(上田)悠依華, 佛坂斉祉, 宮崎敏博, 森石武史, 佛坂由可, 有薗ケイラ, 中村琢也, 吉田教明. Relationship between suppression of orthodontically induced root resorption by lithium and hylinization (ischemic cell death). 日本矯正歯科学会大会プログラム・抄録集. 2022. 81st
近藤愛理, 近藤愛理, 佛坂斉祉, 佛坂由可, 近藤崇伸, 近藤崇伸, 有薗ケイラ, 橋本恵, 吉田教明. Effects of Lithium chloride on alveolar bone morphometry, tooth movement and root resorption in rats. 日本矯正歯科学会大会プログラム・抄録集. 2021. 80th

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Books (2)：

Impacted teeth
2015 ISBN:9784781204185
チェアサイドの歯科英会話
医歯薬出版 2011

Lectures and oral presentations (37)：

小胞体ストレスを介した細胞死における細胞質ATMの関与
(第 30 回日本 Cell Death 学会学術集会 2022)
Enhanced Fixation of Orthodontic Anchor Screws Using β-TCP-An Experiment Using Rats-
(The 80th Annual Meeting of Japanese Orthodontic Society & The 5th International Congress. 2021)
Effect of administration of botulinum toxin type A in masseter on tooth movement in rats
(The 80th Annual Meeting of Japanese Orthodontic Society & The 5th International Congress. 2021)
Suppression of orthodontic root resorption by lithium and elucidation of its mechanism
(The 80th Annual Meeting of Japanese Orthodontic Society & The 5th International Congress. 2021)
Effects of Lithium chloride on alveolar bone morphometry, tooth movement and root resorption in rats
(The 80th Annual Meeting of Japanese Orthodontic Society & The 5th International Congress. 2021)

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Works (12)：

アポトーシス阻害剤による歯根吸収の抑制効果の検討
2009 - 2010
病的歯根吸収の再石灰化治癒機転の研究
2007 - 2009
MAPK 制御による病的歯根吸収の抑制の試み
2003 - 2005
急性炎症性サイトカインを誘導するストレスタンパク質の病的歯根吸収に及ぼす影響研究
2001 - 2003
ストレスタンパク質の骨吸収に与ぼす影響
2001 -

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Education (2)：

1994 - 1994 Doctor of Philosophy
1980 - 1986 Nagasaki University School of Dentistry

Professional career (1)：

(BLANK)

Work history (6)：

2014/12 - 現在 Nagasaki University Graduate School of Biomedical Sciences Department of Orthodontics and Dentofacial Orthopedics Associate professor
2004/12 - 2014/12 Nagasaki University Graduate School of Biomedical Sciences Diveision of Orthodontics and Dentofacial Orthopedics Lecturer
1992/04 - 2004/11 Nagasaki University School of Dentistry Department of Orthodontics Assistant professor
1997/10 - 2000/03 Memorial Sloan-Kettering Cancer Center Cellular biochemistry and Biophysics Program Postdoctorial Fellow
1987/04 - 1992/03 Nagasaki University School of Detistry, Dental Hospital Orthodontics Assistant professor

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Committee career (9)：

2021/04 - 現在長崎大学数理データサイエンス小委員会委員
2021/04 - 現在長崎大学歯学部再任委員会委員
2020/04 - 現在長崎大学キャリアセンター運営委員会委員
2017/10 - 現在長崎大学総合病院情報システム管理委員会委員
2012/04 - 現在九州矯正歯科学会評議員

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Awards (5)：

2022/10 - Japan Orthodontic Society Excellent Presentation Award Construction of an orthodontic anchor screw loosening model and investigation of anchor screw fixation effects using β-TCP
2021/11 - The 80th Annual Meeting of Japan Orthodontic Society & The 5th International Congress Excellent Presentation Award
2010 - The 69th Annual Meeting of Japan Orthodontic Society Excellent Presentation Award Repair of orthodontically induced root resorption following continuous force application
2010 - Excellent Exhibition Award
2009 - The 68th Annual Meeting of Japan Orthodontic Society Excellent Presentation Award The effect of long term fluoride intake on orthodontically induced tooth movement and root resorption

Association Membership(s) (9)：

日本口蓋裂学会 , 日本顎変形症学会 , 九州矯正歯科学会 , 日本骨代謝学会 , 歯科基礎医学会 , 日本細菌学会 , 西日本矯正歯科学会 , 日本矯正歯科学会 , World Federation of Orthodontists

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