Rchr
J-GLOBAL ID:200901056818042047
Update date: Mar. 25, 2024
Matsushita Osamu
マツシタ オサム | Matsushita Osamu
Affiliation and department:
Job title:
Professor
Homepage URL (1):
http://www.okayama-u.ac.jp/user/saikin/
Research field (2):
Bacteriology
, Applied microbiology
Research keywords (3):
Bacterial toxins
, domain shuffling
, matrix-anchoring drugs
Research theme for competitive and other funds (43):
- 2023 - 2026 細菌性コラゲナーゼのドメイン協働機構解明とその分子基盤に基づく組織新生因子の創出
- 2021 - 2024 絞扼性神経障害に関与するT細胞サブセットの同定と神経ペプチド による治療法の開発
- 2020 - 2023 バイオミメティック Veing Wrapping による末梢神経障害治療法の確立
- 2019 - 2023 Development of periodontal tissue regeneration therapy for horizontal alveolar bone resorption with collagen-binding FGF-2
- 2019 - 2022 ピロリ菌除菌療法における腸内エコシステム破綻のメカニズムと制御
- 2018 - 2021 Elucidation of substrate recognition mechanism of bacterial collagenases to develop angiogenic drug seeds
- 2018 - 2021 Development of a novel biomimetic vascular graft using original collagen anchoring domain with growth factor
- 2018 - 2021 Delivery of Stem cell/growth factor using in situ-formed hydrogels for fracture repair
- 2017 - 2020 Development of functional multilayered mesenchymal stem cells sheet for lumbar fusion surgery
- 2014 - 2017 Musculoskeletal regeneration using Growth factor-anchored materials
- 2014 - 2017 Clarification of molecular mechanisms underlying the analgesic effect of botulinum toxin and applied study
- 2014 - 2017 Structure-function analysis of bacterial toxins in tissue destruction to apply their functional domains to regenerative medicine
- 2014 - 2017 Establishment of novel osteochondral allografting combined with growth factor- collagen-binding domain fusion technology
- 2014 - 2017 Development of collagen binding VEGF-C for lymphangiogenesis
- 2013 - 2015 Development of novel fracture healing methods using artificical perioteum and collagen-binding growth factor containing a collagen-binding domain from Clostridium histolyticum collagenase
- 2011 - 2013 Preclinical study to elucidate molecular mechanism of matrix anchoring using bacterial proteins
- 2010 - 2012 Generating artificial parenchymal and hollow organs fabricated with collagen fibrils,various cells, and cytokines using a bioreactor that we have developed
- 2009 - 2011 Basic science technology study of new revision total hip arthroplasty using a fusion protein and the nanowire processing
- 2008 - 2010 Translational research on a drug delivery system using substrate binding domain derived from bacterial collagenases
- 2006 - 2007 A study on a mechanism for the transcriptional regulation of an epsilon-toxin gene by a novel type of bent DNA
- 2006 - 2007 Interdisciplinary study on the calcium-dependent conformational change of collagen-binding domain from clostridial collagenases
- 2004 - 2005 A study on the molecular mechanism of substrate recognition by Clostridial collagenases
- 2003 - 2004 A study on the mechanism underlying the action of Clostridium perfringens alpha- and epsilon-toxins to membrane lipid rafts
- 2003 - 2004 Studies on the law temperature-dependent enhancement of transcription by a bent DNA
- 2002 - 2003 Basic research on the development of novel vaccines with collagen-anchoring potency.
- 2002 - 2003 特殊ベント・プロモーターを利用した新規高発現ベクターの構築
- 2001 - 2002 Study on structure biology and molecular pathology of Clostridium perfringens epsilon-toxin
- 2000 - 2001 Drug design based on the three-dimensional structure of collagen-binding domain, and its application
- 2000 - 2001 水素ガス産生用ウエルシュ菌バイオリアクター開発のための基礎研究
- 1999 - 2000 Studies on neurotropism of Clostridium perfringens epsilon-toxin and molecular mechanism of its toxicity toward neuronal cells
- 1999 - 2000 Neuron specific calcium-binding Protein, calbrain, is involved in memory formation.
- 1998 - 1999 Function of promoter upstream bent DNA of the Clostridium perfringens phospholipase C gene
- 1997 - 1999 Analysis of the activation and mode of action of Clostridium perfringens ε-toxin
- 1997 - 1998 コラーゲン結合ドメインによるガス壊疸の発症予防
- 1996 - 1997 Study on function of phospholipase C gene binding protein from Clostridium perfringens
- 1996 - 1996 ウェルシュ菌MSCLチャンネルによる病原遺伝子発現制御に関する研究
- 1994 - 1994 ガス壊疽菌プロテアーゼのプロ領域ペプチドの機能解析
- 1993 - 1994 Function of protein (s) which can bind to an alpha-toxin gene of Clostridium perfringens
- 1993 - 1993 ガス壊疽菌コラゲナーゼの反応機構の解析
- 1991 - 1991 分子生物学的手法による酸耐性セルロース分解菌の作成と,反芻獣肥育事故防止への応用
- 1990 - 1991 Developmental Studies on the Laboratory diagnosis at an early stage of Mycoplasam pneumoniae-infection (mycoplasmal pneumonia)
- -
- -
Show all
Papers (113):
-
Shinnosuke Fukushima, Hideharu Hagiya, Kazuyoshi Gotoh, Shuma Tsuji, Koji Iio, Osamu Matsushita. Detection of imported clinical strain of blaNDM-1-harbouring ST147 Klebsiella pneumoniae from a Ukrainian immigrant. Journal of travel medicine. 2024
-
Takehito Suzuki, Hironobu Murakami, Jumpei Uchiyama, Reiichiro Sato, Iyo Takemura-Uchiyama, Masaya Ogata, Kazuyuki Sogawa, Hiroho Ishida, Apichart Atipairin, Osamu Matsushita, et al. Exploratory study of volatile fatty acids and the rumen-and-gut microbiota of dairy cows in a single farm, with respect to subclinical infection with bovine leukemia virus. Annals of Microbiology. 2023. 73. 1
-
Takuya Yagisawa, Jumpei Uchiyama, Iyo Takemura-Uchiyama, Shun Ando, Osamu Ichii, Hironobu Murakami, Osamu Matsushita, Seiji Katagiri. Metataxonomic Analysis of the Uterine Microbiota Associated with Low Fertility in Dairy Cows Using Endometrial Tissues Prior to First Artificial Insemination. Microbiology spectrum. 2023. 11. 3. e0476422
-
Lutfun Nahar, Hideharu Hagiya, Takahiro Nada, Koji Iio, Kazuyoshi Gotoh, Osamu Matsushita, Fumio Otsuka. Prevalence of Inducible Macrolide, Lincosamide, and Streptogramin B (inducible MLSB) Resistance in Clindamycin-Susceptible Staphylococcus aureus at Okayama University Hospital. Acta Med Okayama. 2023. 77. 1. 1-9
-
Kazutaka Takahashi, Kunitoshi Shigeyasu, Yoshitaka Kondo, Kazuyoshi Gotoh, Shuya Yano, Yuzo Umeda, Toshihiro Inokuchi, Caiming Xu, Kazuhiro Yoshida, Hibiki Umeda, et al. RNA editing is a valuable biomarker for predicting carcinogenesis in ulcerative colitis. Journal of Crohn's & colitis. 2022. 17. 5. 754-766
more...
MISC (44):
-
内山淳平, 内山伊代, 福田憲, 玉井栄治, 金丸周司, 萩谷英大, 松下治. 薬剤耐性緑膿菌感染症に対する人工抗菌酵素の開発. 緑膿菌感染症研究会プログラム・抄録集. 2024. 58th
-
八木沢 拓也, 内山 淳平, 内山 伊代, 安藤 駿, 市居 修, 村上 裕信, 松下 治, 片桐 成二. 乳牛における子宮内細菌叢と受胎性との関連についての検討. 北海道獣医師会雑誌. 2023. 67. 8. 294-294
-
内山 淳平, 内山 伊代, 後藤 和義, 山本 由弥子, 松崎 茂展, 松下 治. ファージvs細菌 その仁義なき?戦い ウラシル含有DNAゲノムを有する巨大ファージの細菌進化への影響. 日本細菌学雑誌. 2023. 78. 1. 19-19
-
八木沢 拓也, 内山 淳平, 内山 伊代, 安藤 駿, 市居 修, 村上 裕信, 松下 治, 片桐 成二. 初回人工授精前の子宮内膜組織を用いた乳牛の低受胎に関わる子宮内細菌叢の解析. 日本細菌学雑誌. 2023. 78. 1. 72-72
-
Asaduzzaman Md, 美間 健彦, 後藤 和義, 山本 由弥子, 内山 淳平, Sakon Joshua, 松下 治. 細菌性コラゲナーゼの構造活性相関の解析(Structure-function analysis of Clostridial collagenases). 日本細菌学雑誌. 2023. 78. 1. 136-136
more...
Patents (33):
-
コラーゲン結合薬剤組成物およびその使用方法
-
コラーゲン結合タンパク質による治療剤の送達
-
Delivery of therapeutic agents using bacterial collagen-binding polypeptide segments
-
Collagen-binding agent compositions and methods of using the same
-
Delivery of therapeutic agents by a collagen binding protein
more...
Books (2):
-
コンパクト微生物学
南江堂 2021 ISBN:9784524226368
-
シンプル微生物学
南江堂 2018 ISBN:9784524254835
Education (2):
- 1984 - 1988 Okayama University Graduate School of Medicine
- 1978 - 1984 Okayama University Medical School Faculty of Medicine
Professional career (1):
- Doctor of Philosophy in Medical Science (Okayama University)
Work history (6):
Committee career (4):
- 2022/08 - 現在 Udayana University International Advisory Board member
- 2013/04 - 現在 岡山市 感染症診査協議会 委員(感染症部会長)
- 2013/04 - 現在 岡山県 備前地域感染症診査協議会 委員
- 2015/01 - 2018/12 日本細菌学会 理事
Awards (1):
- 1999/04 - 日本細菌学会 黒屋奨学賞受賞 ガス壊疽菌群のコラゲナーゼに関する研究
Association Membership(s) (3):
American Society for Microbiology
, 日本感染症学会
, Japanese Society for Bacteriology
Return to Previous Page