OHARA-IMAIZUMI Mica

イマイズミミカ | OHARA-IMAIZUMI Mica

Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： http://www.kyorin-u.ac.jp/univ/user/medicine/insulin/

Research field (3)： Cell biology , Pathobiochemistry , Metabolism and endocrinology

Research keywords (3)： insulin granule exocytosis , Cellular Biochemistry , Diabetes

Research theme for competitive and other funds (24)：

2021 - 2024 2相性インスリン極性分泌機構とその破綻による糖尿病発症
2017 - 2020 Role of the active zone protein, ELKS, in insulin secretion from pancreatic beta cells
2014 - 2018 Mechanisms of increased glucose-stimulated insulin secretion during pregnancy
2011 - 2013 糖尿病原因究明のためのイメージングによるインスリン開口放出機構解明
2011 - 2013 Deletion of CDKAL1 affects first-phase glucose stimulated insulin exocytosis

2008 - 2011 Imaging analysis of impaired insulin exocytosis in type2 diabetes mellitus

2009 - 2010 インスリン分泌顆粒細胞内ロジスティクスのイメージング解析

2008 - 2010 Mechanisms of biphasic insulin granule exocytosis by imaging technique

2006 - 2007 インスリン分泌顆粒細胞内トラフィックのVTIRF解析

2005 - 2007 Imaging analysis reveals mechanistic differences between first and second phase insulin exocytosis

2003 - 2006 Study of impaired insulin exocytosis in diabetes mellitus by imaging technique

2004 - 2005 インスリン分必顆粒輸送の可視化解析-貯蔵からFusionまで-

2002 - 2004 Mechanism of insulin exocytosis in pancreatic β cells by analyzing single insulin granule motion with evanescent wave microscopy

2002 - 2003 脂肪細胞を利用したインスリン分泌機構の再構成

2000 - 2002 Molecular Mechanisms of Exocytotic Proces and Its Regulation

1999 - 2000 Biological activities of InsP5 and InsP6 in neuronal cells : Analysis by single cell amperometory.

1999 - 2000 Role of activated protein kinase C in the mechanism for MgATP-dependent Priming of exocytosis in adrenal chromaffin cells

1998 - 1999 MOLECULAR MECHANISMS OF TRANSMITTER RELEASE

1997 - 1998 開口放出機構におけるシナプトタグミンの役割

1995 - 1995 開口放出における細胞骨格系蛋白質変動の組織化学的研究

1994 - 1995 Regulation of Exocytosis

1994 - 1994 伝達物質放出機構における細胞骨格系蛋白質の役割

1993 - 1994 Roles of G-proteins and cytoskeletal porteins in transmitter release.

1988 - 1989 牛副腎髄質クロマフィン細胞における分泌の調節機構

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Papers (88)：

Kyota Aoyagi, Chiyono Nishiwaki, Yoko Nakamichi, Shun-ichi Yamashita, Tomotake Kanki, Mica Ohara-Imaizumi. Imeglimin mitigates the accumulation of dysfunctional mitochondria to restore insulin secretion and suppress apoptosis of pancreatic β-cells from db/db mice. Scientific Reports. 2024. 14. 1
Kyota Aoyagi, Shun-ichi Yamashita, Yoshihiro Akimoto, Chiyono Nishiwaki, Yoko Nakamichi, Haruhide Udagawa, Manabu Abe, Kenji Sakimura, Tomotake Kanki, Mica Ohara-Imaizumi. A new beta cell-specific mitophagy reporter mouse shows that metabolic stress leads to accumulation of dysfunctional mitochondria despite increased mitophagy. Diabetologia. 2023. 66. 1. 147-162
Haruhide Udagawa, Masaki Hiramoto, Miho Kawaguchi, Takashi Uebanso, Mica Ohara-Imaizumi, Takao Nammo, Wataru Nishimura, Kazuki Yasuda. Characterization of the taste receptor-related G-protein, α-gustducin, in pancreatic β-cells. Journal of diabetes investigation. 2020. 11. 4. 814-822
Mica Ohara-Imaizumi, Kyota Aoyagi, Toshihisa Ohtsuka. Role of the active zone protein, ELKS, in insulin secretion from pancreatic β-cells. Molecular metabolism. 2019. 27S. S81-S91-S91
Kunihiko Araki, Amane Araki, Daiyu Honda, Takako Izumoto, Atsushi Hashizume, Yasuhiro Hijikata, Shinichiro Yamada, Yohei Iguchi, Akitoshi Hara, Kazuhiro Ikumi, et al. TDP-43 regulates early-phase insulin secretion via CaV1.2-mediated exocytosis in islets. The Journal of clinical investigation. 2019. 129. 9. 3578-3593

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MISC (139)：

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Books (13)：

糖尿病学の進歩 2009
(社)日本糖尿病学会編、診断と治療社 2009
Pancreatic beta cell in health and disease
Seino S.and G.I. Bell (eds) Springer Verlag, Berlin Germany 2008
分子糖尿病学の進歩 -基礎から臨床まで-2006
矢崎義雄編, 金原出版 2006
ポスター発表はチャンスの宝庫! : 一歩進んだ発表のための計画・準備から当日のプレゼンまで : in 医学・理学系学会
羊土社 2003 ISBN:9784897063546
ポスター発表はチャンスの宝庫. in医学・理学系学会一歩進んだ発表のための計画・準備から当日のプレゼンまで
羊土社 2003

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Lectures and oral presentations (211)：

インスリン極性分泌のメカニズム
(インスリン分泌研究会 2023)
インスリン極性分泌のメカニズム
(日本生化学会関東支部例会特別講演 2023)
2相性インスリン極性分泌のメカニズム
(第66回日本糖尿病学会年次学術集会 2023)
アクティブゾーンタンパク質のインスリン極性分泌における役割
(第23回臨床内分泌病理学会)
Role of active zone protein ELKS in insulin secretion from pancreatic β-cells
(20th Anniversary Servier-IGIS Symposium “Biomarkers of Beta-Cell Health & Dysfunction: Towards Personalised Diabetes Care” (Saint Jean Cap Ferrat, France))

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Professional career (1)：

Work history (7)：

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Association Membership(s) (5)：

日本神経化学会 , 日本糖尿病学会 , 日本生化学会 , 日本内分泌学会 , 日本細胞生物学会

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