Rchr

J-GLOBAL ID：200901057478554591 Update date: Apr. 08, 2024

Tsujigiwa Hidetsugu

ツジギワヒデツグ | Tsujigiwa Hidetsugu

Affiliation and department：
Homepage URL (1)： http://www.dls.ous.ac.jp/index.html

Research field (3)： Tumor biology , Oral medicine (pathology) , Regenerative dentistry and dental engineering

Research keywords (4)：バイオマティリアルの開発と骨誘導解析の分子生物学的研究。口腔腫瘍 , Histopathology of oral Diseases and Tumors , Molecular Pathological study of Odontogenic tumor and Tooth formation , Medelular Biological study of Development of New Biomaterials and Bone Induction

Research theme for competitive and other funds (51)：

2024 - 2027 考古遺跡より出土する部分骨格標本の分子生物学的研究とその開発
2022 - 2025 口腔癌間質が主導する実質進展制御メカニズム解明と新規治療法開発
2021 - 2025 細胞競合による癌の生物学的性格および癌化の制御
2020 - 2025 口腔扁平上皮癌における新規遠隔転移抑制治療の開発
2020 - 2023 3,500万年前の哺乳類化石を用いた化石分子系統解析手法の開発とその応用

2020 - 2023 miRNAが支配する骨・軟骨分化方向決定メカニズムの解明

2018 - 2022 Regulation of the biological character of cancer and induction of cancer by the cancer stroma.

2018 - 2022 A study for MRONJ and its presymptomatic diagnosis from the viewpoint of changes in immunity and matrix protein structure of bone

2017 - 2021 Involvement and function elucidation of stromal cells in the process of bone invasion of odontogenic tumors

2016 - 2019 Involvement of bone marrow mesenchymal cells in the repair of dentin-pulp complex

2016 - 2019 Characterization and potential roles of bone marrow-derived stromal cells in premetastasis niche

2015 - 2019 Establishment of new skull tissue reconstruction method based on reproduction of bone micro environment

2015 - 2018 Pathological study for the osteoporosis produced by the osteoblastic niche and hematopoietic stem cells

2015 - 2018 Skin tissue bud formation by in vitro self-organization approach

2014 - 2018 Characterization and potential roles of bone marrow-derived stromal cells in cancer development and metastasis

2014 - 2017 Elucidation of the molecular mechanisms of the periodontal tissue repair

2014 - 2017 Molecular pathology of phenotypic chenges in lesions of jow bones

2014 - 2017 Pathogenesis research on oro-maxillary cytological proliferative lesions

2014 - 2017 A new reconstruction method using intraosseous microenvironment reproduction system of segmental excision bone

2013 - 2016 Molecular control mechanism of cell suppling, migration and differentiation in remodeling of periodontal ligament

2013 - 2016 Development of novel treatment and functional analysis of molecular regulation of Sjogren's syndrome by using mesenchymal stem cells

2013 - 2016 Subpopulation of dental pulp stem/progenitor cells: Their implication in the differentiation capacity, origin, and microenvironment

2012 - 2016 Functional analysis of candidate tumor suppressor gene, RIZ in oral squamous cell carcinoma.

2012 - 2015 New system for facial bone tissue reconstruction by the reproduction of a microenvironment in the bone tissue

2012 - 2015 Mimic periodontal tissue by using in vitro dentin

2012 - 2015 Development of a treatment model for osteoporosis using an inner bone environment system

2012 - 2015 Molecular imaging analysis of the antitumour activity of 5-fluorouracil combine with Mycobacterium bovis bacillus Calmette-Guérin (BCG) in the mouse oral cancer model.

2010 - 2014 Differentiation induction of mesenchymal stem cells in the peripheral blood into tooth structure forming cells

2011 - 2014 象牙質シートを用いた生体機能付加インプラントシステムの開発

2011 - 2013 Elucidation of the molecular mechanisms of tissue repair using stem cells

2011 - 2013 Elucidation of the cell differentiation molecular regulation mechanism in proliferative lesions of the oral cavity using bone marrow stem cell transplantation model

2010 - 2012 Elucidation of molecular regulation mechanism and promotion of the orthodontic remodeling using the bone marrow stem cell

2009 - 2011 Bone regeneration with osteoblast gel and artificial bone marrow which can produce interaction between stem cells

2008 - 2010 Development of a new tooth coating with anti-carious and anti-periodontitis properties by using nanoparticles of Calcium Titanate

2008 - 2009 Differentiation induction of bone marrow stem cells into tooth component cells

2007 - 2009 Basic research of a novel dental material : Calcium Titanium Oxide-Amorphous Carbon for applying the lining material

2007 - 2008 Bone regeneration with bone marrow stem cell and immobilized cytokine

2007 - 2008 The effect of cancer stem cell on Epithelial to Mesenchymal Transition.

2007 - 2008 Loss of heterozygosity analysis and its relationship with Clinicopathological features in ameloblastoma

2005 - 2008 Research Technological Study of Tumor Gene Analysis in Oral Cancer and Odontogenic Tumor for Asian People.

2005 - 2007 Study on olfactory regeneration by implantation of bone marrow cells or tissue stem cells

2005 - 2006 Analysis of molecular genetics to the bone resorption mechanism that an immune cell causes

2005 - 2006 Role of heparanase in odontogenic tumors

2005 - 2006 Application of Immobilized Cytokine for Regeneration Medicine in Head and neck Region

2003 - 2006 Molecular biological analysis of tooth germ and odontogenic tumor

2004 - 2005 Guided tissue regeneration with immobilized cytokine

2003 - 2004 歯牙形成過程における基底膜IV型コラーゲンα鎖の機能解析

2003 - 2004 Development of an osteoporosis model pro-culture by immunity restraint agent and molecular biology analysis of bone absorption mechanism

2002 - 2003 Cbfa1を用いた単一遺伝子疾患に対する遺伝子治療の基礎的研究

2000 - 2002 Molecular pathological study of tooth germ and odonto genic tumor

1999 - 2001 Gene expression of BMP family and receptors during tooth development

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Papers (136)：

Yasunori Inada, Kiyofumi Takabatake, Hidetsugu Tsujigiwa, Keisuke Nakano, Qiusheng Shan, Tianyan Piao, Anqi Chang, Hotaka Kawai, Hitoshi Nagatsuka. Novel Artificial Scaffold for Bone Marrow Regeneration: Honeycomb Tricalcium Phosphate. Materials (Basel, Switzerland). 2023. 16. 4
稲田靖則, 高畠清文, 辻極秀次, 河合穂高, 中野敬介, 長塚仁. 新規生体材料の幾何学的構造制御による象牙質再生. 岡山歯学会雑誌. 2021. 40. 2. 36-37
Kiyofumi Takabatake, Hidetsugu Tsujigiwa, Aki Yoshida, Takayuki Furumatsu, Hotaka Kawai, May Wathone Oo, Keisuke Nakano, Hitoshi Nagatsuka. A Pilot Study of Seamless Regeneration of Bone and Cartilage in Knee Joint Regeneration Using Honeycomb TCP. Materials (Basel, Switzerland). 2021. 14. 23
Inada Yasunori, Takabatake Kiyofumi, Tsujigiwa Hidetsugu, Kawai Hotaka, Nakano Keisuke, Nagatsuka Hitoshi. 歯髄由来細胞の分化を制御するためのハニカムTCPの幾何構造(Geometrical structure of honeycomb TCP to control dental pulp-derived cell differentiation). Journal of Hard Tissue Biology. 2021. 30. 4. 401-401
Haruka Omori, Qiusheng Shan, Kiyofumi Takabatake, Keisuke Nakano, Hotaka Kawai, Shintaro Sukegawa, Hidetsugu Tsujigiwa, Hitoshi Nagatsuka. The Origin of Stroma Influences the Biological Characteristics of Oral Squamous Cell Carcinoma. Cancers. 2021. 13. 14

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MISC (234)：

武部祐一郎, 辻極秀次, 高畠清文, 稲田靖則, 藤井昌江, 河合穂高, 中野敬介, 長塚仁. Effect of CCN2 secreted by ameloblastoma on bone resorption through tumor stroma. 日本口腔腫瘍学会総会・学術大会プログラム・抄録集. 2023. 41st
稲田靖則, 高畠清文, 辻極秀次, 河合穂高, 中野敬介, 長塚仁. ハニカム構造を有するTCPを応用した骨髄組織誘導. 日本口腔科学会学術集会プログラム・抄録集. 2023. 77th
中桐僚子, 渡部聡子, 渡邊敏之, 高畠清文, 辻極秀次, 木股敬裕. ハニカムβ-TCPによる骨組織再建. 日本形成外科学会総会・学術集会プログラム・抄録集. 2021. 64th
高畠清文, 河合穂高, OO May Wathone, 吉田沙織, 大森悠加, 中野敬介, 辻極秀次, 長塚仁. 口腔扁平上皮癌の腫瘍微小環境における骨髄由来細胞の分化と役割. 日本口腔科学会学術集会プログラム・抄録集. 2020. 74th
高畠清文, 辻極秀次, 浜田芽衣, 河合穂高, 吉田沙織, 大森悠加, 中野敬介, 長塚仁. ハニカムTCPの幾何学構造による血管新生を介した選択的骨・軟骨組織形成制御. 日本口腔科学会雑誌. 2019. 68. 2. 179-179

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Books (11)：

Oral Cancer: Causes, Diagnosis and Treatment
Nova Science Publishers 2011
Bacterial DNA, DNA Polymerase and DNA Helicases
Nova Biomedical Books 2009
Drug Resistant Neoplasms
Nova Biomedical Books 2009
Proceedings of the 4th International Symposium on Apatites and Correlative Biomaterials
2008
Progress in oral cancer research
Nova Biomedical Books,USA 2008

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Lectures and oral presentations (132)：

MECHANICAL STRESS AS A POSSIBLE PROMOTER OF TRANSPLANTED BONE MARROW-DERIVED CELLMIGRATION INTO PERIODONTAL TISSUES
(20th International Conference on Oral and Maxillofacial Surgery 2011)
頭頸部扁平上皮癌におけるDKK3タンパクおよび遺伝子発現と予後との相関
(第70回日本癌学会学術総会 2011)
ラット歯髄由来象牙芽細胞株の細胞生物学的解析
(第53回歯科基礎医学会学術大会ならびに総会 2011)
エナメル上皮腫におけるCCN2の発現解析
(第20回硬組織再生生物学会学術大会・総会 2011)
Notch signaling proteins in primary and recurrent chondrosarcoma of the jaw: A case report
(第22回日本臨床口腔病理学会総会・学術大会 2011)

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Education (4)：

- 2001 Okayama University
- 2001 Okayama University Graduate School, Division of Dental Research
- 1994 Okayama University of Science Faculty of Science
- 1994 Okayama University of Science Faculty of Science

Professional career (1)：

博士(歯学) (岡山大学)

Work history (2)：

2014/04 - - 岡山理科大学教授
2010 - - Associate Professor,Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,Okayama University

Committee career (1)：

2010 - 歯科基礎医学会評議員

Association Membership(s) (8)：

日本癌学会 , 日本口腔科学会 , 日本口腔病理学会 , 日本生化学会 , 歯科基礎医学会 , 硬組織再生生物学会 , 岡山歯学会 , 日本病理学会

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