Terada Koji

テラダコウジ | Terada Koji

Affiliation and department：

Research field (6)： Molecular biology , Immunology , Pharmacology , Medical biochemistry , Cell biology , Tumor diagnostics and therapeutics

Research keywords (7)：分子生物学 , 免疫学 , 薬理学 , 生化学 , 細胞生物学 , 腫瘍学 , 発生生物学

Research theme for competitive and other funds (8)：

2022 - 2025 iPS細胞の応用による腫瘍微小環境のT細胞抑制効果に耐性をもつ新規T細胞製剤開発
2019 - 2022 ゲノム編集をヒトとサルのiPS細胞に用いたがんに対するT細胞製剤の新規作製法開発
2013 - 2016 Molecular mechanism of trafficking regulation of G protein-coupled receptor
2013 - 2014 エンドセリン B型受容体の発現調節機構の破綻による動脈硬化症の発症・進展機構の解明
2009 - 2011 Study of the regulatory mechanism of ETAR and ETBR level by receptor binding protein and the relevance between clinical significance and endothelin receptor level.

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Papers (43)：

近藤健太, 長谷川達矢, 寺田晃士, 口分田美奈, 新田信人, 縣保年. ビタミンCによるCD8T細胞(キラーT細胞)の機能制御機構の解明. ビタミン. 2022. 96. 5-6. 261-262
Koji Terada, Kenta Kondo, Hirohito Ishigaki, Ayaka Nagashima, Hiroki Satooka, Seiji Nagano, Kyoko Masuda, Teruhisa Kawamura, Takako Hirata, Kazumasa Ogasawara, et al. Isolation of TCR genes with tumor-killing activity from tumor-infiltrating and circulating lymphocytes in a tumor rejection cynomolgus macaque model. Molecular therapy oncolytics. 2022. 24. 77-86
Takuya Maeda, Seiji Nagano, Soki Kashima, Koji Terada, Yasutoshi Agata, Hiroshi Ichise, Manami Ohtaka, Mahito Nakanishi, Fumihiro Fujiki, Haruo Sugiyama, et al. Regeneration of Tumor-Antigen-Specific Cytotoxic T Lymphocytes from iPSCs Transduced with Exogenous TCR Genes. Molecular Therapy - Methods & Clinical Development. 2020. 19. 250-260
Takahiro Horinouchi, Yuichi Mazaki, Koji Terada, Soichi Miwa. Cigarette Smoke Extract and Its Cytotoxic Factor Acrolein Inhibit Nitric Oxide Production in Human Vascular Endothelial Cells. Biological and Pharmaceutical Bulletin. 2020. 43. 11. 1804-1809
Takahiro Horinouchi, Yuichi Mazaki, Koji Terada, Soichi Miwa. Extracellular Ca2+ promotes nitric oxide production via Ca2+-sensing receptor-Gq/11 protein-endothelial nitric oxide synthase signaling in human vascular endothelial cells. Journal of Pharmacological Sciences. 2020. 143. 4. 315-319

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MISC (22)：

堀之内孝広, 真崎雄一, 寺田晃士, 三輪聡一. 血管内皮細胞におけるカルシウム感受性受容体を介した一酸化窒素産生機序. 日本薬理学雑誌. 2020. 155. Supplement
寺田晃士, 石垣宏仁, 近藤健太, 長嶋彩花, 里岡大樹, 永野誠治, 増田喬子, 川村晃久, 河本宏, 平田多佳子, et al. カニクイザルの腫瘍拒絶モデルにおける腫瘍浸潤T細胞からの腫瘍殺傷能をもつTCR遺伝子の単離. 日本分子生物学会年会プログラム・要旨集(Web). 2020. 43rd
堀之内孝広, 寺田晃士, 東恒仁, 真崎雄一, 三輪聡一. Phos-tag biotinを用いた受容体作動性TRPC6チャネルのPKAリン酸化部位の同定. 電気泳動(Web). 2016. 60. Suppl
Tsunehito Higashi, Yosuke Mai, Takahiro Horinouchi, Koji Terada, Akimasa Hoshi, Mika Horiguchi, Prabha Nepal, Takuya Harada, Chizuru Hatate, Soichi Miwa. Identification of cytotoxic compounds in cigarette smoke gas phase and molecular mechanisms for their cytotoxicity. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2014. 124. 131P-131P
Soichi Miwa, Koji Terada, Tsunehito Higashi, Nepal Prabha, Takahiro Horinouchi. A critical role of ubiquitination in endothelin receptor trafficking. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2014. 124. 34P-34P

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Lectures and oral presentations (63)：

Isolation of TCR genes with tumor-killing activity from tumor-infiltrating lymphocytes in a tumor rejection cynomolgus macaque model
(2021)
Development of “TCR cassette method”: Regeneration of CTLs from iPSCs in which tumor-antigen specific TCR genes can be efficiently introduced into the endogenous TCR locus by cassette
(2021)
”TCRカセット法“の開発:がん抗原特異的TCR遺伝子を内在性TCR遺伝子座へ効率よく導入する
(Kyoto T cell Conference 第30回学術集会 2021)
"TCRカセット法"の開発:がん抗原特異的TCR遺伝子を内在性TCR遺伝子座へ効率よく導入できるiPS細胞から細胞傷害性T細胞を再生する
(第43回日本分子生物学会年会 2020)
カニクイザルの腫瘍拒絶モデルにおける腫瘍浸潤T細胞からの腫瘍殺傷能をもつTCR遺伝子の単離
(第43回日本分子生物学会年会 2020)

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Education (2)：

1995 - 2000 東京工業大学大学院生命理工学研究科
1991 - 1995 東京工業大学生命理工学部

Professional career (1)：

博士(理学)

Work history (5)：

2014/12 - 現在 Shiga University of Medical Science Undergraduate School of Medicine, Faculty of Medicine
2011/04 - 2014/11 Hokkaido University Graduate School of Medicine
2001/09 - 2011/03 Osaka Bioscience Institute
2000/05 - 2001/08 University of Texas Southwestern Medical Center Center for Developmental Biology
2000/04 - 2000/04 Crest 特別研究員

Association Membership(s) (6)：

American Society for Cell Biology , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE JAPANESE BIOCHEMICAL SOCIETY , THE JAPANESE PHARMACOLOGICAL SOCIETY , 日本免疫学会 , 日本がん免疫学会

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