Nakayama Misako

ナカヤマミサコ | Nakayama Misako

Affiliation and department：
Job title： Postdoctoral researcher with an EU MCSA fellowship
Homepage URL (1)： https://www.helmholtz-munich.de/en/lhi

Research field (4)： Virology , Immunology , Laboratory animal science , Experimental pathology

Research keywords (7)： Nonhuman primate model , Mucosal Immunity , Host-Pathogen Interaction , SARS-CoV-2 , Influenza virus , Vaccination , Airway organoid

Research theme for competitive and other funds (7)：

2023 - 2025 Epithelial-mesenchymal crosstalk in the pathology of influenza virus infection: https://cordis.europa.eu/project/id/101107766
2020 - 2022 Revealing pathology of COPD exacerbation caused by influenza virus in an in vitro COPD model
2020 - 2022 Elucidation of mechanisms involved in increased severety of influenza virus infection by using in vitro models of asthma and COPD
2016 - 2019 ヒト単球上の潜在型TGF-βの発現調節機構とその発現比率による単球の機能差の解明
2018 - 2018 Grants for overseas study for postdoctoral researchers

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Papers (50)：

Cong Thanh Nguyen, Misako Nakayama, Hirohito Ishigaki, Yoshinori Kitagawa, Akemi Kakino, Marumi Ohno, Masashi Shingai, Yasuhiko Suzuki, Tatsuya Sawamura, Hiroshi Kida, et al. Increased expression of CD38 on endothelial cells in SARS-CoV-2 infection in cynomolgus macaque. Virology. 2024. 110052-110052
Hirohito Ishigaki, Sayaka Ito, Takako Sasamura, Hideaki Ishida, Misako Nakayama, Cong Thanh Nguyen, Takaaki Kinoshita, Shingo Suzuki, Chizuru Iwatani, Hideaki Tsuchiya, et al. MHC-DRB alleles with amino acids Val11, Phe13, and the shared epitopes promote collagen-induced arthritis and a rapid IgG1 response in Filipino cynomolgus macaques. HLA. 2024. 103. 1
Hirohito Ishigaki, Sayaka Ito, Takako Sasamura, Hideaki Ishida, Misako Nakayama, Cong Thanh Nguyen, Takaaki Kinoshita, Shingo Suzuki, Chizuru Iwatani, Hideaki Tsuchiya, et al. MHC-DRB alleles with amino acids Val11, Phe13, and the shared epitopes promote collagen-induced arthritis and a rapid IgG1 response in Filipino cynomolgus macaques. HLA. 2024. 103. 1. e15316
Shino Shimizu, Misako Nakayama, Cong Thanh Nguyen, Hirohito Ishigaki, Yoshinori Kitagawa, Fumihiko Yasui, Yoshiki Yagi, Tomoe Kusayanagi, Michinori Kohara, Yasushi Itoh, et al. SARS-CoV-2 induces inflammation and intracranial infection through the olfactory epithelium-olfactory bulb pathway in non-human primates. Journal of Neuroimmunology. 2024. 578288-578288
Eri Kawakami, Norikazu Saiki, Yosuke Yoneyama, Chiharu Moriya, Mari Maezawa, Shuntaro Kawamura, Akiko Kinebuchi, Tamaki Kono, Masaaki Funata, Ayaka Sakoda, et al. Complement factor D targeting protects endotheliopathy in organoid and monkey models of COVID-19. Cell stem cell. 2023. 30. 10. 1315-1330

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MISC (48)：

清水志乃, 仲山美沙子, 石垣宏仁, Nguyen Thanh Cong, 北川善紀, 伊藤靖, 清水猛史. 「感染・免疫研究の新潮流」非ヒト霊長類の嗅上皮から嗅球におけるSARS-CoV-2感染の病態. 日本耳鼻咽喉科免疫アレルギー感染症学会抄録集. 2023. 3回. 84-84
塩原正規, 仲山美沙子, 石垣宏仁, 伊藤靖. インフルエンザ不活化全粒子ワクチンはB細胞の体細胞高頻度突然変異を誘導する。. 日本病理学会会誌. 2023. 112. 1. 242-242
仲山美沙子, 北川直子, 石垣宏仁, Nguyen Thanh Cong, 石田英明, 鈴木紗織, 小笠原一誠, 伊藤靖. サルにおけるH5N1不活化全粒子ワクチン接種5年後の肺炎予防効果. 日本病理学会会誌. 2023. 112. 1. 242-242
森河友里, 仲山美沙子, 笹村孝子, 石垣宏仁, 伊藤靖. 慢性呼吸器疾患患者由来の気道オルガノイドにおけるインフルエンザおよび新型コロナウイルス受容体の発現. 日本病理学会会誌. 2023. 112. 1. 382-382
清水志乃, 仲山美沙子, 石垣宏仁, Nguyen Thanh Cong, 北川善紀, 伊藤靖, 清水猛史. 「感染・免疫研究の新潮流」非ヒト霊長類の嗅上皮から嗅球におけるSARS-CoV-2感染の病態. 日本耳鼻咽喉科免疫アレルギー感染症学会抄録集. 2023. 3回. 84-84

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Patents (3)：

SARS-CoV-2 NEUTRALIZING ANTIBODY OR FRAGMENT THEREOF
METHOD FOR IN VITRO PROLIFERATING VIRUS BELONGING TO FAMILY CORONAVIRIDAE, METHOD FOR PRODUCING NEUTRALIZING ANTIBODY TO VIRUS BELONGING TO FAMILY CORONAVIRIDAE, AND METHOD FOR PRODUCING INFECTION MODEL OF SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2
細胞補集材及び細胞補集用カラム

Lectures and oral presentations (102)：

Expression of avian-type flu receptor is negatively correlated with differentiation in primary human bronchial epithelial cells
(European Respiratory Society International Congress 2023, Milan, Italy 2023)
Influenza and SARS-CoV-2 receptors in an airway organoid from patients with chronic lung diseases
(The 112th annual congress of Japanese Society of Pathology 2023)
Inactivated whole influenza virus particle vaccines promote somatic hypermutation in B-lymphocytes
(The 112th annual congress of Japanese Society of Pathology 2023)
Five-year efficacy of an H5N1 inactivated whole virus particle vaccine against pneumonia in monkeys
(The 112th annual congress of Japanese Society of Pathology 2023)
The utility of air-liquid interface culture in respiratory virus research
(Reiwa science talk 2023)

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Education (3)：

2009 - 2014 Shiga University of Medical Science Faculty of Medicine, PhD course
2000 - 2006 Shiga University of Medical Science Faculty of Medicine
2005 - 2005 St George's University of London Medical Oncology

Work history (7)：

2023/09 - 現在 Helmholtz Center Munich Institute of Lung Health and Immunity Postdoctoral researcher with an EU MCSA fellowship
2008/12 - 2023/08 Shiga University of Medical Science Department of Pathology Assistant Professor
2017/11 - 2019/03 Helmholtz Center Munich Comprehensive Pneumology Center Guest Scientist
2017/01 - 2017/05 Parental Leave
2011/01 - 2011/05 Parental Leave

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Awards (2)：

2014/10 - Shiga University of Medical Science Best Research Prize for Women Investigators
2014/04 - Japanese Society of Pathology Pathology Research Prize for Young Investigators

Association Membership(s) (3)：

European Respiratory Society , THE JAPANESE SOCIETY FOR IMMUNOLOGY , THE JAPANESE SOCIETY OF PATHOLOGY

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