Nohmi Takehiko

ノウミタケヒコ | Nohmi Takehiko

Affiliation and department：
Job title： Visiting Scientist
Other affiliations (1)：

National Institute of Biomedical Innovation Coodinator

Research field (4)： Pharmaceuticals - health and biochemistry , Molecular biology , Environmental effects of chemicals , Environmental effects of radiation

Research keywords (9)： carcinogenesis , drug development , ゲノム不安定性 , DNAポリメラーゼ , 環境変異原 , 突然変異 , Genome instability , DNA polymerase , Mutation Mutagen

Research theme for competitive and other funds (17)：

2014 - 2018 Research on roles of DNA polymerase kappa in mechanisms underlying threshold of genotoxic carcinogens
2013 - 2017 Studies on quantitative evaluation of inherited germline mutations
2011 - 2014 Involvement of oxidative stress in the epigenetic changes induced by environmental chemicals
2010 - 2014 Research on mechanisms underlying genotxic threshold by genetic modifications of DNA polymerase zeta
2009 - 2011 Assessment of in vivo mutagenicity and trans-generational effect of compounds contained in suspended particulate matter in urban air

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Papers (223)：

Mizuki Ohno, Noriko Takano, Kyoko Hidaka, Fumiko Sasaki, Kazumi Yamauchi, Yasunobu Aoki, Takehiko Nohmi, Yusaku Nakabeppu, Yoshimichi Nakastu, Teruhisa Tsuzuki. Oxidative stress accelerates intestinal tumorigenesis by enhancing 8-oxoguanine-mediated mutagenesis in MUTYH-deficient mice. Genome research. 2024
Ken Kuroda, Yuji Ishii, Shinji Takasu, Aki Kijima, Kohei Matsushita, Ken-Ichi Masumura, Takehiko Nohmi, Takashi Umemura. Possible contribution of 8-hydroxydeoxyguanosine to gene mutations in the kidney DNA of gpt delta rats following potassium bromate treatment. Mutation research. Genetic toxicology and environmental mutagenesis. 2024. 894. 503729-503729
Tatsuya Mitsumoto, Yuji Ishii, Norifumi Takimoto, Shinji Takasu, Moeka Namiki, Takehiko Nohmi, Takashi Umemura, Kumiko Ogawa. Site-specific genotoxicity of rubiadin: localization and histopathological changes in the kidneys of rats. Arch. Toxicol. 2023
Atsushi Hakura, Hajime Sui, Yuki Seki, Jiro Sonoda, Yusaku Yoshida, Hisayoshi Takagi, Shigeo Yokose, Tomonari Matsuda, Shoji Asakura, Takehiko Nohmi. DNA polymerase κ suppresses inflammation and inflammation-induced mutagenesis and carcinogenic potential in the colon of mice. Genes and environment : the official journal of the Japanese Environmental Mutagen Society. 2023. 45. 1. 15-15
Shinji Takasu, Yuji Ishii, Moeka Namiki, Kenji Nakamura, Tatsuya Mitsumoto, Norifumi Takimoto, Takehiko Nohmi, Kumiko Ogawa. Comprehensive analysis of the general toxicity, genotoxicity, and carcinogenicity of 3-acetyl-2,5-dimethylfuran in male gpt delta rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023. 172. 113544-113544

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MISC (290)：

中村賢志, 石井雄二, 高須伸二, 能美健彦, 渋谷淳, 小川久美子. 染色体異常を起点とするacetamideの肝発がん機序の検討. 第37回日本毒性病理学会. 2021
中村賢志, 石井雄二, 木島綾希, 高須伸二, 能美健彦, 渋谷淳, 小川久美子. gpt deltaラットを用いたacetamideのラット肝発がんメカニズムに関する検討. 日本毒性病理学会講演要旨集. 2020. 36回. 80-80
中村賢志, 中村賢志, 石井雄二, 木島綾希, 高須伸二, 能美健彦, 能美健彦, 渋谷淳, 小川久美子. Possible involvement of chromosome aberrations and DNA damages in acetamide-induced hepatocarcinogenesis in rats. Journal of Toxicological Sciences. 2020. 45. Supplement. S92-S92
増村健一, 安東朋子, 鵜飼明子, 藤原聖, 横瀬重雄, 高木久宜, 能美健彦, 本間正充. High packaging efficiency in reporter gene mutation assay using new gpt delta transgenic rat with homozygous transgene. 日本癌学会学術総会抄録集(Web). 2020. 79th
魏民, 藤岡正喜, 梯アンナ, 奥野高裕, 増村健一, 能美健彦, 松本道治, 大森雅子, 鰐渕英機, 福島昭治. In vivo Positive Mutagenicity of 1,4-dioxane and Quantitative Analysis of Its Mutagenicity and Carcinogenicity in Rats. 大阪市医学会雑誌. 2020. 69

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Patents (4)：

突然変異検出用トランスジェニックラットとその作製方法およびそれを用いた突然変異試験法
遺伝子突然変異検出用トランスジェニックマウス及び遺伝子突然変異試験方法
遺伝子突然変異検出用トランスジェニックマウス
新規なラムダーファージDNAおよびその利用

Books (2)：

Thresholds of genotoxic carcinogens
Elsevier 2016
Archaea: new models for prokaryotic biology
Caister Academic Press 2008 ISBN:9781904455271

Works (2)：

ハイ・スループット遺伝毒性試験系の開発
2004 - 2006
Development of high throughput genotoxicity assays
2001 -

Education (2)：

1976 - 1978 Tokyo University of Agriculture and Technology Graduate School of Agriculture Agricultural Chemistry
1971 - 1976 Saitama University Department of Sciences Biochemistry

Professional career (1)：

Doctor of Philosophy (Tokyo College of Pharmacy)

Work history (9)：

2012/04 - 現在 National Institute of Health Sciences Biological Safety Research Center Visiting Scientist
2012/04 - 現在 National Institute of Health Sciences Scientist Emeritus
2015/04 - 2017/03 Japan Agency for Medical Research and Development Innovation of Drug Discovery and Development Coordinator
2013/05 - 2015/03 National Institute of Biomedical Innovation Center for Innovative Drug Discovery and Development Coordinator
2012/05 - 2013/05 National Institute of Biomedical Innovation Department of Research and Development Promotion Program Officer

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Committee career (9)：

2009/12 - 現在環境省有害大気汚染物質の健康リスク評価手法等に関するガイドライン策定検討会委員
2007/10 - 現在内閣府食品安全委員会委員器具・包装容器専門調査会専門委員
2004/05 - 2022/03 独立行政法人医薬品医療機器総合機構専門委員
2007/04 - 2021/09 内閣府食品安全委員会委員動物用医薬品専門調査会専門委員会委員
2009/01 - 2019/01 厚生労働省薬事・食品衛生審議会薬事分科会、化学物質安全対策部会、化学物質調査会専門委員

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Awards (2)：

2006 - The Japanese Environmental Mutagen Society JEMS Award
1992 - The Japanese Environmental Mutagen Society JEMS Annual Award

Association Membership(s) (7)：

THE JAPANESE SOCIETY OF TOXICOLOGY , THE JAPANESE CANCER ASSOCIATION , Environmental Mutagenesis and Genomics Society , 日本分子生物学会 , 日本環境変異原学会 , The Japanese Environmental Mutagen Society , The Molecular Biology Society of Japan

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