Kijima Hiroshi

キジマヒロシ | Kijima Hiroshi

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://www.med.hirosaki-u.ac.jp/~patho2/

Research field (2)： Human pathology , Molecular biology

Research keywords (4)：分子生物学 , 人体病理学 , Molecular Biology , Human Pathology

Research theme for competitive and other funds (26)：

2022 - 2025 Elucidation of perineural invasion of distal cholangiocarcinoma using tissue clearing method
2021 - 2024 胆膵癌の概日リズムに関連した高悪性度形質とその制御
2018 - 2022 Pathophysiology and growth control of the microenvironment in colorectal cancer with highly invasive growth
2018 - 2021 Breast cancer microenvironment control targeting clock gene and its development of MRI imaging
2017 - 2020 Pathophysiological modulation of high-grade malignant potentials of pancreato-biliary cancer, and its clinical application

2016 - 2019 Breast cancer microenvironment control targeting clock gene and its clinical application

2016 - 2019 Study of the prevention and complementary treatment of advanced cancer: Examination of presymptomatic diagnosis and reactivation of cancer suppression mechanism

2015 - 2018 Functional analysis of "angio-lymphatic vessels" in the neoplastic lesions - its histopathological significance

2013 - 2016 The use of fluorescent L-glucose derivative as a marker of early gastro-colonic cancer on routine endoscopy.

2010 - 2012 The study of the development of anti-cancer drug which targets human septin 4 (Bradeion) GTPase

2011 - 2011 Functional alalysis of clock genes in highly aggressive pancreato-biliary cancer

2008 - 2010 Clock genes regulates tumor growth and tumor angiogenesis of human pancreato-biliary cancer.

2007 - 2008 Histological analysis of the osteochondritis dissecans

2006 - 2007 Development of cancer therapeutic technology by functional measurement and control of cell division.

2005 - 2006 Pathology and molecular targeting of human pancreatic cancer

2003 - 2004 Development of monitoring system of colorectal cancer

2002 - 2003 Antioxidant Agents Therapy for Esophageal Mucosa with Inducible Nitric Oxide Syntlaase Expression

2000 - 2001 Bradeion, the gene expressed in colorectal cancer specifically --its functional analysis and technical development of clinical application--

2000 - 2001 Characterization of ras oncogene functions in human cancer using ribozyme-mediated specific gene modulation

1999 - 2001 食道の老化

1999 - 2000 Knock-down mouse, a novel gene engineering mouse for use as a disease model

1998 - 2000 Regulation of pancreatic β-cell function by glutathione

1997 - 1998 Intracellular localization of multidrug resistance associated protein (MRP) and atypical multidrug resistance phenomenon in non-small cell lung cancer

1997 - 1998 Anti-oncogene hammerhead ribozymes (RNA enzymes) specifically inhibit oncogens in a mice model system.

Specific modulation of gene expression

Molecular Biology of Cancer

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Papers (159)：

Shunsuke Kubota, Takuya Miura, Taiichi Wakiya, Tadashi Yoshizawa, Shintaro Goto, Hajime Morohashi, Yoshiyuki Sakamoto, Yota Tatara, Hiroshi Kijima, Kenichi Hakamada. Exploration of Malignant Characteristics in Neoadjuvant Chemotherapy-Resistant Rectal Cancer, Focusing on Extramural Lesions. Annals of surgical oncology. 2023
Keisuke Yamazaki, Taiichi Wakiya, Keinosuke Ishido, Norihisa Kimura, Daichi Ichinohe, Yoshiya Takahashi, Tadashi Yoshizawa, Hiroshi Kijima, Kenichi Hakamada. A case of serous cystic neoplasm with tumor growth acceleration leading to extrapancreatic invasion. Clinical journal of gastroenterology. 2023. 16. 2. 289-296
Shintaro Goto, Tadashi Yoshizawa, Keinosuke Ishido, Hiroko Seino, Satoko Morohashi, Hirokazu Ogasawara, Shunsuke Kubota, Kenta Ogasawara, Akie Nakamura, Kenichi Hakamada, et al. Use of time-density curves of dynamic contrast-enhanced computed tomography for determination of the histological therapeutic effects of neoadjuvant chemotherapy for pancreatic ductal adenocarcinoma. Oncology reports. 2023. 49. 3
Takafumi Yachi, Tadashi Yoshizawa, Norihisa Kimura, Hiroko Seino, Satoko Morohashi, Shintaro Goto, Keinosuke Ishido, Hiroshi Kijima, Kenichi Hakamada. 18F-fluorodeoxyglucose positron emission tomography predicts recurrence and histological grade of extrahepatic bile duct cancer. Oncology letters. 2023. 25. 3. 125-125
Hirokazu Ogasawara, Tadashi Yoshizawa, Kiyoko Oshima, Kenta Ogasawara, Shunsuke Kubota, Shintaro Goto, Satoko Morohashi, Taiichi Wakiya, Norihisa Kimura, Keinosuke Ishido, et al. Three-dimensional analysis of perineural invasion in extrahepatic cholangiocarcinoma using tissue clearing. Pathology oncology research : POR. 2023. 29. 1611284-1611284

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MISC (105)：

田中壽和, 田中芳美, 野呂大輔, 杉山尚樹, 鈴木裕一朗, 岡本亜希子, 山本勇人, 今井篤, 畠山真吾, 米山高宏, et al. 腎原発神経内分泌腫瘍の一例. 泌尿器外科. 2016. 29. 2. 187-187
Yakoshi Yuta, Kudo Daisuke, Toyoki Yoshikazu, Isido Keinosuke, Kimura Norihisa, Wakiya Taiichi, Sakuraba Shingo, Yoshizawa Tadashi, Sakamoto Yoshiyuki, Kijima Hiroshi, et al. Non-Invasive Quantification of Liver Damage by a Novel Application for Statistical Analysis of Ultrasound Signals. The Hirosaki medical journal. 2014. 65. 2. 199-208
脇屋太一, 工藤大輔, 豊木嘉一, 石戸圭之輔, 木村憲央, 矢越雄太, 鳴海俊治, 鬼島宏, 袴田健一. PS-214-6 大腸癌肝転移切除症例における化学療法による肝障害度とICG検査との相関について(PS ポスターセッション,第113回日本外科学会定期学術集会). 日本外科学会雑誌. 2013. 114. 2. 820
脇屋太一, 工藤大輔, 豊木嘉一, 石戸圭之輔, 木村憲央, 矢越雄太, 鳴海俊治, 鬼島宏, 袴田健一. 大腸癌肝転移切除症例における化学療法による肝障害度とICG検査との相関について. 日本外科学会雑誌. 2013. 114
工藤大輔, 豊木嘉一, 石戸圭之輔, 木村憲央, 脇屋太一, 村田曉彦, 小山基, 坂本義之, 諸橋一, 矢越雄太, et al. 大腸癌肝転移;Consensus&Controversy 薬物療法;最近のトピックス化学療法による肝障害. 肝胆膵. 2013. 67. 4

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Education (4)：

- 1988 Niigata University Graduate School of Medicine
- 1988 Niigata University Graduate School, Division of Medicine
- 1984 Niigata University Faculty of Medicine School of Medicine
- 1984 Niigata University Faculty of Medicine

Professional career (2)：

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Work history (7)：

2007/04 - Hirosaki University Graduate School of Medicine
2004/08 - 2007/03 Hirosaki University School of Medicine
2003/04 - 2004/07 Tokai University School of Medicine
1997/04 - 2003/03 Tokai University School of Medicine
1996/04 - 1997/03 大和市立病院病理(出向)

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Association Membership(s) (6)：

American Association for Cancer Research , 日本臨床細胞学会 , 日本胆道学会 , 日本消化器病学会 , 日本癌学会 , 日本病理学会

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