Research keywords (2)：
応用微生物
, Applied Microbiology
Research theme for competitive and other funds (35)：
2023 - 2028 Understanding the Intestinal Survival Strategy of Altruistic Bifidobacteria by Human Glycan Binding from the Molecular Structure
2021 - 2024 腸管細胞の獲得免疫における動態評価
2021 - 2024 Enzymatic insight into the microbiota formation in infant guts
2019 - 2022 Molecular basis of mRNA exporter's diversification by evolution of mRNA nuclear exporters in eukaryotic cells
2019 - 2022 Clarification of the molecular mechanism how zinc deficiency is associated with IBD
2019 - 2021 Physiological role of bifidus flora formation in breast-fed infant guts
2018 - 2021 Development of an in vitro co-culture system for elucidation of host-gut microbiota symbiotsis
2017 - 2021 Clarification of the mechanism of effectiveness of the oral cancer vaccine a platform expressing a cancer antigen
2017 - 2019 Host-microbe symbiosis mediated through symbiogenic factors
2017 - 2019 Exploration for the substance to promote brain development of offspring on the basis of analyses on the quality of mother milk of a mouse model with perturbed gut microbiota
2015 - 2018 Human milk oligosaccharides as the bifidus factor: the mechanism underlying how bifidus flora is established in infant guts
2014 - 2017 Development of novel HCV treatment using oral vaccine
2014 - 2016 Screening of novel symbiogenic factors which exploit the future of studies of intestinal bacteria
2013 - 2016 Development of the innovative technique for addition of sugar chain using microbial enzymes and its application on the syntheses of functional glycoconjugates
2013 - 2016 Construction and analyses of gene knock-out mutants collection of Bifidobacterium to understand Bifidobacterium-human symbosis
2012 - 2015 Studies on cellulases for the construction of biorefinary from cellulose
2012 - 2015 Milk oligosaccharides-mediated symbiosis and co-evolution between bifidobacteria and humans
2012 - 2014 Search for new antifungal agent based on finding of biosynthetic pathway of novel glycosphingolipids
2011 - 2013 Development of a novel oral therapeutic HCV vaccine using bifidobacterium displaying antigen
2010 - 2011 What establishes the symbiotic relationship between human and bifidobacteria?"A bifidogenic effects of human milk oligosaccharides"
2009 - 2011 Studies on microbial aromatic L-amino acid decarboxylase
2008 - 2010 Novel oral vaccine using genetically engineering bifidobacterium displaying antigen on its cell-surface
2008 - 2010 Biosynthetic engineering of isoquinoline alkaloids in microbes
2008 - 2009 Symbiotic relationship between human and bifidobacteria : Understanding and exploiting the functions of bifidobacterial glycosidases.
2007 - 2008 Conversion of inverting glycosidases to glycosynthasesand its application to regio- and stereospecific synthesis ofoligosaccharide
2006 - 2007 多機能リアーゼの高度機能特化とLードーパ生産の新展開
2006 - 2007 酵素デザインによるオンサイト芳香発生システムの開発
2006 - 2007 Production of Novel Bioactive Compounds Using Microbial Endoglycosidases and Its Enzymatic Analyses
1999 - 2007 微生物のアミノ酸・糖代謝にかかわるタンパク質とその遺伝子
1999 - 2007 Structural and functional analysis of enzymes and genes involved in metabilism of amino acid and suger in microorganism
2004 - 2006 Research and Development of Thermo-stable Cellulases for the Construction of Recycing Industrial System
2004 - 2005 Elucidation of function and biosynthetic pathway of novel glycosphingolipid found in filamentous fungi and their application for finding of antibiotics
2002 - 2003 プロバイオティックスを用いる乳酸菌セラピーの基礎研究
2002 - 2003 Synthesis of artificial mucin, which is a barrier for living body, using microbial endo-type glycosidase and its application
Koichi Kitagawa, Mako Kato, Shota Komai, Ryota Sako, Hazuki Doi, Yoshiko Hashii, Takane Katayama, Toshiro Shirakawa. Preclinical Study of Oral Cancer Vaccine Using Recombinant Bifidobacterium Expressing WT1 Protein in Murine Bladder Cancer Model and Non-Human Primate. MOLECULAR THERAPY. 2020. 28. 4. 35-36
平野里佳, 平野里佳, 阪中幹祥, 阪中幹祥, 杉本直久, 江口省吾, 奈良未沙希, 片山高嶺, 北岡本光, 北岡本光, et al. Analysis of mechanism of selective promotion of growth in bifidobacteria with next generation prebiotic Galactosyl-β1,4-rhamnose. 日本農芸化学会大会講演要旨集(Web). 2020. 2020
Hikaru Minagawa, Yoshiko Hashii, Natsuki Nakagawa, Hiroko Nakajima, Yoshihiro Oka, Takane Katayama, Toshiro Shirakawa, Keiichi Ozono. The anti-tumor effect of oral cancer vaccine using Bifidobacterium as a platform for displaying Wilms' tumor 1 protein. JOURNAL OF CLINICAL ONCOLOGY. 2019. 37. 8
Koichi Kitagawa, Maho Tatsumi, Mako Kato, Shota Komai, Yoshiko Hashii, Takane Katayama, Toshiro Shirakawa. Cancer immunotherapy combining oral vaccination of recombinant Bifidobacterium longum displaying human Wilms' tumor 1 protein and anti-PD-1 checkpoint blockade for solid tumors in mice experimental model. CANCER IMMUNOLOGY RESEARCH. 2019. 7. 2
Enzymes involved in mucin O-glycan degradation by Bifidobacterium bifidum International Symposium on Microbial Glycoconjugates and the GlySpace Alliance: from micro to macro glycoscience
(MiGGA (online) 2022)
Enzymatic insight into gut microbiota formation in breastfed infants
(2021)
2002/04 - 2005/03 Assistant Professor, Kyoto University
1999/04 - 2002/03 Kyoto University Graduate School of Agriculture
1999/04 - 2002/03 research associate,
Ishikawa Prefectural University Research Institute for Bioresources and Biotechnology Associate Professor
Kyoto University
Graduate School of Agricultural,
Division of Applied Life Science,
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Association Membership(s) (10)：
ビタミン学会
, 日本糖質学会
, アメリカ微生物学会
, 日本生化学会
, 日本農芸化学会
, The Japanese Society of Carbohydrate Research
, American Society for Microbiology
, The Japanese Biochemical Society
, Biotechnology and Agricultue
, Japan Society for Bioscience
