Rchr
J-GLOBAL ID：200901059587911054   Update date: Feb. 01, 2024

Honda Shinya

Honda Shinya
Affiliation and department：
国立研究開発法人産業技術総合研究所 バイオメディカル研究部門

About 国立研究開発法人産業技術総合研究所 バイオメディカル研究部門


Job title： 副研究部門長
Other affiliations (1)：
  • 東京大学  大学院新領域創成科学研究科 メディカルゲノム専攻   客員教授
Homepage URL  (1)： http://www.aist.go.jp/RESEARCHERDB/cgi-bin/worker_detail.cgi?call=namae&rw_id=S77531757
Research field  (3)： Pharmaceuticals - analytical and physicochemistry ,  Biochemistry ,  Biophysics
Research keywords  (4)： バイオ医薬品 ,  熱力学 ,  生物物理学 ,  タンパク質デザイン
Research theme for competitive and other funds  (4)：
  • 2022 - 2025 治療用抗体の凝集化メカニズム解明:構造劣化抗体の分子構造、種間交差、細胞内動態
  • 2019 - 2022 Elucidation of the mechanism of physicochemical stress-induced aggregation of therapeutic antibodies and development of a theory to predict aggregation
  • 2014 - 2017 Design of Humanized Adaptor Proteins Exhibiting Albumin-Binding Affinity
  • 2011 - 2014 molecular design and synthesis of cyclized cytokines for biobetter development
Papers (111)：
  • Takaaki Kurinomaru, Kimitoshi Takeda, Megumi Onaka, Yuki Kuruma, Keiji Takahata, Kayori Takahashi, Hiromu Sakurai, Akira Sasaki, Naohiro Noda, Shinya Honda, et al. Optimization of Flow Imaging Microscopy Setting Using Spherical Beads with Optical Properties Similar to Those of Biopharmaceuticals. Journal of pharmaceutical sciences. 2023. 112. 12. 3248-3255
  • Yosuke Yasuzawa, Risa Shibuya, Yukako Senga, Takamitsu Miyafusa, Shinya Honda. Determination of the optimal connector length to enhance stability of backbone-circularized granulocyte colony-stimulating factor. FEBS open bio. 2023. 13. 10. 1910-1921
  • Hiroshi Imamura, Ayako Ooishi, Shinya Honda. Getting Smaller by Denaturation: Acid-Induced Compaction of Antibodies. J. Phys. Chem. Lett. 2023. 14. 16. 3898-3906
  • Hiroshi Imamura, Shinya Honda. Cue to acid-induced long-range conformational changes of antibody preceding the aggregation: structural origins of the subpeaks in Kratky plots of the small-angle X-ray scattering. International Journal for Molecular Sciences. 2023. 24. 15. 12042
  • Yukako Senga, Motomichi Doi, Masayoshi Onitsuka, Shinya Honda. Live-cell imaging to analyze intracellular aggregation of recombinant IgG in CHO cells. Cell Chemical Biology. 2022. 29. 1. 120-132.e4
ｍore...
MISC (72)：
ｍore...
Patents (36)：
ｍore...
Professional career (1)：
  • 博士(理学)
Association Membership(s) (4)：
The Biophysical Society (USA) ,  The Protein Society (USA) ,  日本蛋白質科学会 ,  日本生物物理学会
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page

TOP

BOTTOM