Rchr
J-GLOBAL ID：200901060325886545
Update date: Apr. 01, 2024
Ishikawa Tomohisa
イシカワ トモヒサ | Ishikawa Tomohisa
Affiliation and department：
Homepage URL (1)：
https://w3pharm.u-shizuoka-ken.ac.jp/pharmaco/
Research field (2)：
Nutrition and health science
, Pharmacology
Research keywords (6)：
肝線維症
, hepatic stellate cell
, diabetes
, pancreatic β cells
, lipid metabolism
, insulin secretion
Research theme for competitive and other funds (23)：
- 2023 - 2026 肥満誘発β細胞代償性増殖ブレーキの解除を活用した脂質分子による血糖調節戦略の構築
- 2023 - 2026 肝星細胞における液-液相分離を標的としたNASH進行スイッチ制御の確立
- 2021 - 2024 AI搭載ガスクロマトグラフを応用した呼気分析によるNASH進行非侵襲判定法の開発
- 2020 - 2023 細胞内脂質シグナルを標的としたβ細胞量増大による糖尿病治療の確立に向けた検証研究
- 2020 - 2023 Basic study for developing NASH therapeutic drugs by using a small molecule derived from the cellular slime mold serving as a lead compound
- 2018 - 2021 Development of disease model in mice on the basis of mechanisms for pathogenesis of gestational diabetes.
- 2019 - 2021 リコンビナントCytoglobinを用いた脱肝線維化治療薬開発に関する研究
- 2017 - 2020 2型糖尿病発症過程におけるインスリン分泌異常と細胞内脂質代謝異常の時系列相関解析
- 2017 - 2020 Intracellular lipid signaling analysis for the development of novel diabetes therapeutic agents targeting neogenesis and proliferation of pancreatic beta-cells
- 2015 - 2018 Possible involvement of gut-derived melatonin as a negative regulator of insulin secretion
- 2011 - 2013 Role of crosstalk between peripheral circadian clock and NO-cGMP system of pancreatic beta-cells in the pathogenesis of diabetes
- 2008 - 2010 Intermolecular network involved in calcium-dependent apoptosis of pancreatic beta-cells and possible targets for diabetes treatment
- 2006 - 2007 Molecular mechanisms for regulation of glucose metabolism in skeletal muscle cells by biomechanical stress.
- 2005 - 2007 Roles of TRP channels in response to exposure with high concentrations of glucose in pancreatic β cells
- 2001 - 2002 Physiological role of NO produced by constitutive NO synthase in pancreatic islet of Langerhans
- 2000 - 2002 Realtime imaging analysis of tyrosine phosphorylation in response to hemodynamic forces
- 1999 - 2000 Analysis of intracellular mechanisms contributing to insulin secretion from pancreatic β-cells
- 1997 - 1998 Contraction-excitation feedback in heart failure and cardiac hypertrophy
- 1997 - 1998 内皮由来過分極因子の作用メカニズムの解明
- 1996 - 1998 The role new pepdidergic neuron in autoregulation of regional blood flow.
- 1995 - 1997 Analysis of dedifferentiation and growth of glial cells in tissue regeneration process after brain damage
- 1996 - 1996 血管平滑筋弛緩反応におけるイオンチャンネルの関与
- 1989 - 1989 心臓における第3の神経-CGRP作動性神経-の生理的意義の解明
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Papers (110)：
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Megumi Kaji, Yukiko K Kaneko, Stella Amarachi Ihim, Ran Kanoh, Moe Yamamoto, Momoka Yamaguchi, Tomohisa Ishikawa. Oral ingestion of Shiikuwasha extract suppresses diabetes progression in db/db mice by preserving β-cell mass. Frontiers in nutrition. 2024. 10. 1336133-1336133
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Soshiro Kodera, Toshihide Kimura, Tomoki Nishioka, Yukiko K Kaneko, Momoka Yamaguchi, Kozo Kaibuchi, Tomohisa Ishikawa. GDP-bound Rab27a regulates clathrin disassembly through HSPA8 after insulin secretion. Archives of biochemistry and biophysics. 2023. 749. 109789
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Mai Kato, Momoka Yamaguchi, Akira Ooka, Ryota Takahashi, Takuji Suzuki, Keita Onoda, Yuko Yoshikawa, Yuta Tsunematsu, Michio Sato, Yasukiyo Yoshioka, et al. Non-target GC-MS analyses of fecal VOCs in NASH-hepatocellular carcinoma model STAM mice. Scientific reports. 2023. 13. 1. 8924-8924
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Hirotake Ishida, Tomohisa Ishikawa, Shin-ya Saito. Enhanced Contraction of Arterial Smooth Muscle Cell in Skin Artery Is Sensitive to Hyperpolarization Mediated by BK<sub>Ca</sub> Channel in Chronic Constriction Injury Model Rat. Biological and Pharmaceutical Bulletin. 2023. 46. 3. 399-403
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Stella Amarachi Ihim, Yukiko K Kaneko, Moe Yamamoto, Momoka Yamaguchi, Toshihide Kimura, Tomohisa Ishikawa. Apigenin Alleviates Endoplasmic Reticulum Stress-Mediated Apoptosis in INS-1 β-Cells. Biological & pharmaceutical bulletin. 2023. 46. 4. 630-635
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MISC (88)：
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森野純鈴, 山口桃生, 岡部磨幸, 河合佑美, 金子雪子, 柴田涼吾, 大岡央, 金沢貴憲, 石川智久. 植物由来エキソソーム様ナノ粒子が肝星細胞の活性化制御および細胞への取り込みに及ぼす影響. 生体膜と薬物の相互作用シンポジウム講演要旨集. 2023. 44th
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岡部磨幸, 山口桃生, 大岡央, 森野純鈴, 柴田涼吾, 金沢貴憲, 金子雪子, 石川智久. Effects of plant-derived exosome-like nanoparticles on the activation of hepatic stellate cells. 日本薬学会年会要旨集(Web). 2023. 143rd
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柴田涼吾, 金子雪子, 山口桃生, 森野純鈴, 金沢貴憲, 石川智久. 膵β細胞アポトーシスに対する植物由来エキソソーム様ナノ粒子の効果の検証. 次世代を担う若手のための創薬・医療薬理シンポジウムプログラム・要旨集. 2023. 2023
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森野純鈴, 山口桃生, 金沢貴憲, 飯岡真吾, 土肥直貴, 近藤啓, 石川智久. Evaluation of hepatocyte-derived exosomes on physical characteristics and uptake into hepatic stellate cells. 日本薬学会年会要旨集(Web). 2022. 142nd
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渡辺雄太, 山口桃生, 金沢貴憲, 森野純鈴, 飯岡真吾, 東顕二郎, 土肥直貴, 近藤啓, 石川智久. 肝実質細胞由来EVの物性と肝星細胞への指向性に及ぼす脂肪酸暴露の影響. 日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会講演要旨集. 2022. 2022 (Web)
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Books (3)：
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学際的創薬科学論-有機化学・薬理・構造生物学・薬物動態・安全性から創
京都廣川書店 2019 ISBN:4909197427
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詳解 薬理学
廣川書店 2015 ISBN:4567495101
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図解薬理学
南山堂 2015 ISBN:9784525720612
Education (3)：
- - 1989 University of Tsukuba
- - 1986 University of Tsukuba Graduate School, Division of Medicine
- - 1984 Tokyo University of Science Faculty of Pharmaceutical Sciences Department of Pharmacy
Professional career (2)：
- M.S. (University of Tsukuba)
- Ph.D. (University of Tsukuba)
Work history (11)：
- 2023 - 現在 University of Shizuoka School of Pharmaceutical Sciences
- 2006 - 現在 静岡県立大学薬学部 教授
- 2019 - 2023 静岡県立大学大学院 薬学研究院長
- 2019 - 2021 静岡県立大学大学院 薬食生命科学総合学府長
- 2015 - 2019 University of Shizuoka School of Pharmaceutical Sciences
- 1998 - 2006 University of Shizuoka School of Pharmaceutical Sciences
- 1994 - 1998 University of Tsukuba Institute of Basic Medical Sciences
- 1993 - 1994 米国ネバダ大学医学部生理学教室 Research Assistant Professor
- 1991 - 1993 米国ネバダ大学医学部生理学教室 Research Associate
- 1990 - 1991 University of Tsukuba Institute of Basic Medical Sciences
- 1989 - 1990 日本学術振興会 特別研究員
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Committee career (7)：
Association Membership(s) (4)：
日本循環薬理学会
, 日本糖尿病学会
, 日本薬学会
, 日本薬理学会
