HIROSHI SEKIGUCHI

セキグチヒロシ | HIROSHI SEKIGUCHI

Affiliation and department：
Job title：主幹研究員

Research field (4)： Quantum beam science , Biophysics , Nanobioscience , Nanomaterials

Research keywords (7)： single molecule experiment , atomic force microscopy , ナノ計測 , 生物科学研究法 , 生物物理学 , Research methods in biological sciences , Biophysics

Research theme for competitive and other funds (21)：

2023 - 2026 X線を用いた高速1分子運動解析による膜タンパク質オペランド計測の実現
2022 - 2025 Study of Serious Problems of Conventional Methods in the Evaluation of Ultimate Mechanical Property of Polymer Crystals as a Guiding Principle for the Development of Ultra-Strong Polymers
2021 - 2024 クチナーゼCut190のCa2+結合に伴う動的構造変化とPET分解分子機構の解明
2020 - 2023 Determination of single hemoglobin dynamics with x-rays
2020 - 2021 生きた細胞におけるチャネルタンパク質・X線1分子動態アッセイシステムの開発

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Papers (103)：

Yue Yang, Tatsuya Arai, Daisuke Sasaki, Masahiro Kuramochi, Hidetoshi Inagaki, Sumiko Ohashi, Hiroshi Sekiguchi, Kazuhiro Mio, Tai Kubo, Yuji C. Sasaki. Real-time tilting and twisting motions of ligand-bound states of α7 nicotinic acetylcholine receptor. European Biophysics Journal. 2024. 53. 1-2. 15-25
A. Rack, H. Sekiguchi, K. Uesugi, N. Yasuda, Y. Takano, T. Okinaka, A. Iguchi, L. Milliere, B. Lukić, M.P. Olbinado, et al. Recent developments in MHz radioscopy: Towards the ultimate temporal resolution using storage ring-based light sources. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 2024
Tsutomu Yamane, Takahiro Nakayama, Toru Ekimoto, Masao Inoue, Keigo Ikezaki, Hiroshi Sekiguchi, Masahiro Kuramochi, Yasuo Terao, Ken Judai, Minoru Saito, et al. Comparison of the Molecular Motility of Tubulin Dimeric Isoforms: Molecular Dynamics Simulations and Diffracted X-ray Tracking Study. International Journal of Molecular Sciences. 2023. 24. 20. 15423-15423
Erika Tsutsumi, Satomi Niwa, Ryota Takeda, Natsuki Sakamoto, Kei Okatsu, Shuya Fukai, Hideo Ago, Satoshi Nagao, Hiroshi Sekiguchi, Kazuki Takeda. Structure of a putative immature form of a Rieske-type iron-sulfur protein in complex with zinc chloride. Communications chemistry. 2023. 6. 1. 190-190
Masahiro Kuramochi, Henry J. Kirkwood, Jayanath C. P. Koliyadu, Romain Letrun, Raphael de Wijn, Chan Kim, Tomomi Masui, Kazuhiro Mio, Tatsuya Arai, Hiroshi Sekiguchi, et al. Direct observation of 890 ns dynamics of carbon black and polybutadiene in rubber materials using diffracted x-ray blinking. Applied Physics Letters. 2023. 123. 10

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MISC (163)：

谷中慶三郎, 大久保達成, 大久保達成, 新井達也, 野澤俊介, 関口博史, 古山若呼, 南保明日香, 三尾和弘, 三尾和弘, et al. Molecular dynamics of cell membrane in Ebola virus proliferation using Diffracted X-ray Blinking. 量子ビームサイエンスフェスタ(Web). 2023. 2022
宮部俊宏, 小園裕子, 笠寺浩介, 松宮陽, 関口博史, 沖本憲明, 泰地真久人, 佐々木裕次, 小園晴生. Dynamical Analysis of Peptide Exchange Mechanism of HLA-DM by Diffracted X-ray Tracking Method. SPring-8/SACLA利用研究成果集(Web). 2021. 9. 1
Masaki Ishihara, Shoko Fujimura, Kohei Ichiyanagi, Shunsuke Nozawa, Shinichi Adachi, Ryo Fukaya, Masahiro Kuramochi, Hiroshi Sekiguchi, Kazuhiro Mio, Yuji C. Sasaki. Dynamic Internal Motion of GPCR on Live Cells. BIOPHYSICAL JOURNAL. 2020. 118. 3. 56A-56A
J-W. Chang, Y. S. Baek, K. Mio, M. Mio, H. Sekiguchi, Y. C. Sasaki. X-ray single molecule dynamics of interleukins bonded receptors on live NK cells membranes. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2017. 46. S374-S374
Y. C. Sasaki, K. Ikezaki, K. Mio, H. Sekiguchi. New X-ray single molecular observations from super-Poisson distribution using laboratory X-rays. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2017. 46. S192-S192

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Patents (1)：

抗原抗体反応の検出方法と抗原抗体反応検出用キット

Books (7)：

3D Local Structure and Functionality Design of Materials
Maruzen Publishing 2018 ISBN:9789813273665
SPring-8 Research Frontiers 2014,
2015
Advances in Chemical Physics, Volume 146, Single Molecule Biophysics: Experiments and Theories
WILEY 2011 ISBN:9781118057803
走査プローブ顕微鏡 (実験物理科学シリーズ6)
共立出版 2009 ISBN:9784320033818
Applied Scanning Probe Methods IX : Characterization
Springer 2008 ISBN:9783540740827

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Lectures and oral presentations (58)：

放射光X線を利用したバイオ・ソフトマテリアルのダイナミクス計測
(バイオインタラクション研究会第22回ワークショップ 2023)
Allosteric transition dynamics in hemoglobin Reconsidered by Diffracted X-ray Tracking
(The 60th Annual Meeting of the Biophysical Society of Japan 2022)
SWAXSビームラインにおけるCITIUS利用に向けて
(第35回日本放射光学会・放射光科学合同シンポジウム 2022)
カーネル密度推定による小角散乱測定終了条件設定
(第10回JASRIワークショップ/第2回データ駆動科学によるデータ解析高度化 2021)
Utilizations of Synchrotron X-ray for Bio-soft materials at SPring-8
(Shanghai Synchrotron Radiation Facility Seminar 2019)

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Education (4)：

2001 - 2004 Tokyo Institute of Technology Graduate School of Bioscience & Biotechnology Department of Life Sciences
1999 - 2001 Tokyo Institute of Technology Graduate School of Bioscience & Biotechnology Department of Life Sciences
1995 - 1999 Tokyo Institute of Technology Graduate School of Bioscience & Biotechnology
1991 - 1994 千葉県立木更津高等学校普通科

Professional career (1)：

Doctor of Science (Tokyo Institute of Technology)

Work history (17)：

2023/10 - 現在 RIKEN SPring-8 Center, Life Science Research Infrastructure Group visiting researcher
2022/04 - 現在 Japan Synchrotron Radiation Research Institute Research Project Division Researcher
2021/04 - 現在 Japan Synchrotron Radiation Research Institute
2019/04 - 現在 Japan Synchrotron Radiation Research Institute
2019/04 - 2023/12 The University of Tokyo Graduate School of Frontier Sciences

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Committee career (7)：

2022/08 - 現在 Scientific Reports Editorial Board Member
2017/10 - 2019/09 The Japanese Society for Synchrotron Radiation Research Editorial Board Member
2012/04 - 2018/03 Foundation Advanced Technology Institute Bio Single-Molecule Committee
2016/05 - 2018/01 The Japanese Society for Synchrotron Radiation Research Program Committee
2015/04 - 2016/03 日本生物物理学会分野別専門員 (放射光)

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Awards (4)：

2022/06 - Shape Memory and Superelasticity 2021 Best Paper Award Dynamics of Phase Fronts During High-Driving-Force Transformation of Shape Memory Alloy Wires
2012/08 - International Workshop on 3D atomic imaging at nano-scale active sites Best Poster Awards Cooperativity analysis of multi-subunit proteins by 3D X-ray single molecule tracking
2007 - Surface Science Society of Japan Young-Researcher Lecture Award
2007 - Surface Science Society of Japan Young Researcher Award

Association Membership(s) (4)：

THE JAPANESE SOCIETY FOR SYNCHROTRON RADIATION RESEARCH , Protein Science Society of Japan , Biophysical Society of Japan , Biophysical society

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