Hara Eiji

ハラエイジ | Hara Eiji

Affiliation and department：
Job title： Professor

Research field (1)： Pathobiochemistry

Research keywords (3)： Cellular Senescence , Gut microbiota , Cell Cycle

Research theme for competitive and other funds (18)：

2022 - 2025 Studies on the role of gut bacteria and cellular senescence in age-related carcinogenesis and its control
2019 - 2023 口腔・大腸マイクロバイオーム解析による大腸がんリスク診断および予防概念の創生
2014 - 2017 Study of obesity-associated carcinogenesis and its application to cancer prevention
2010 - 2016 Integrative Research on Cancer Microenvironment Network
2012 - 2015 Understanding of the anti-apoptotic mechanisms in senescent cells

Show all

Papers (120)：

Seidai Sato, Kazuya Koyama, Hirohisa Ogawa, Kojin Murakami, Takeshi Imakura, Yuya Yamashita, Kozo Kagawa, Hiroshi Kawano, Eiji Hara, Yasuhiko Nishioka. A novel BRD4 degrader, ARV-825, attenuates lung fibrosis through senolysis and antifibrotic effect. Respiratory investigation. 2023. 61. 6. 781-792
Takanori Matsuura, Yoshihide Ueda, Yoshiyuki Harada, Kazuki Hayashi, Kisara Horisaka, Yoshihiko Yano, Shinichi So, Masahiro Kido, Takumi Fukumoto, Yuzo Kodama, et al. Histological diagnosis of polyploidy discriminates an aggressive subset of hepatocellular carcinomas with poor prognosis. British journal of cancer. 2023. 129. 8. 1251-1260
Emiko Urano, Yumi Itoh, Tatsuya Suzuki, Takanori Sasaki, Jun-Ichi Kishikawa, Kanako Akamatsu, Yusuke Higuchi, Yusuke Sakai, Tomotaka Okamura, Shuya Mitoma, et al. An inhaled ACE2 decoy confers protection against SARS-CoV-2 infection in preclinical models. Science translational medicine. 2023. 15. 711. eadi2623
Tatsuyuki Matsudaira, Sosuke Nakano, Yusuke Konishi, Shimpei Kawamoto, Ken Uemura, Tamae Kondo, Koki Sakurai, Takaaki Ozawa, Takatoshi Hikida, Okiru Komine, et al. Cellular senescence in white matter microglia is induced during ageing in mice and exacerbates the neuroinflammatory phenotype. Communications biology. 2023. 6. 1. 665-665
Shimpei Kawamoto, Ken Uemura, Nozomi Hori, Lena Takayasu, Yusuke Konishi, Kazutaka Katoh, Tomonori Matsumoto, Masae Suzuki, Yusuke Sakai, Tatsuyuki Matsudaira, et al. Bacterial induction of B cell senescence promotes age-related changes in the gut microbiota. Nature cell biology. 2023. 25. 6. 865-876

ｍore...

MISC (41)：

Ken Uemura, Shimpei Kawamoto, Masahiro Wakita, Eiji Hara. Obesity associated alternation of the skin microbiota promotes skin carcinogenesis in mice. CANCER SCIENCE. 2022. 113. 1081-1081
Masahiro Wakita, Eiji Hara. Clearance of senescent cells by BET-family protein degrader and their potential for cancer therapy. CANCER SCIENCE. 2022. 113. 1431-1431
渡邉すぎ子, 原英二. p16からみた細胞老化--加齢性疾患の予防・治療に向けたsenolytic薬の発展. 医学のあゆみ. 2018. 267. 13. 1143-1149
河本新平, 大谷直子, 原英二, 原英二. 老化・寿命研究の最先端 5.腸内細菌と細胞老化による発がん促進機構. 実験医学. 2017. 35. 20
羅智文, 羅智文, 蒲池史卓, 渡辺喜洋, 神田浩明, 大島正伸, 岩間厚志, 有田誠, 原英二, 大谷直子. 腸内細菌叢が肥満誘導性肝癌の進展を促進する:デオキシコール酸(DCA)とリポタイコ酸(LTA)の協調作用. 日本生化学会大会(Web). 2017. 90th

ｍore...

Books (19)：

マイクロバイオームとエイジング、セノリティクス
肝胆膵・アークメディア 2023
【抗老化医療の未来をさぐる:哺乳類における老化・寿命制御の理解とその社会実装】細胞老化と個体老化
Geriatric Medicine・ライフ・サイエンス 2023
細胞老化現象に着目した新たながん治療戦略
実験医学・羊土社 2022
細胞老化機構を俯瞰する
Geriatric Medicine 2021
cGAS-STING経路は細胞老化による炎症反応を誘発する
実験医学・羊土社 2021

ｍore...

Lectures and oral presentations (50)：

Comparative analysis of the characteristics of oropharyngeal cancer affected by HPV status
(第82回日本癌学会学術総会 2023)
Polyploidy accompanies DNA damage but meanwhile mitigates its impact
(第1回倍数性研究会 2023)
Genome doubling determines a characteristic subset of hepatocellular carcinoma with aggressive features
(第82回日本癌学会学術総会 2023)
Dynamics of heterogenous cancer-associated fibroblasts in human pancreatic cancers in the clinical course
(第82回日本癌学会学術総会 2023)
がんと老化における細胞老化の役割とその制御
(日本集中治療医学会九州支部学術集会 2023)

ｍore...

Awards (4)：

2021/02 - Princess Takamatsu Cancer Research Fund Princess Takamatsu Cancer Research Fund Prizes
2020/06 - 東京理科大学第3回東京理科大学物理学園賞
2014/10 - 日本癌学会 JCA-Mauvernay Award
2012/01 - 公益財団法人がん研究会学術賞

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page