MATSUMOTO Takeo

2018 - 2021 Morphogenesis-based manufacturing: Construction of optimal structures utilizing mechanical adaptation phenomena

2015 - 2021 Virtual laboratory to accelerate international collaboration on 3D morphological logic

2015 - 2020 Establishment of visualization of stress distribution in fresh embryos toward understanding of morphogenesis from biomechanical viewpoint

2015 - 2020 3D morphologic

2017 - 2019 Feasibility study on cell function control utilizing intranuclear dispersion of DNA induced with mechanical stimulation to the nucleus

2016 - 2018 Study on a mechanical memory of the intracelualr forces and stractures

2015 - 2018 Three-dimensional analysis of microscopic stress and strain fields in biological tissues to elucidate mechanical adaptation mechanism and its comparison with biochemical field

2014 - 2016 Study on temporal deterioration of endothelial cell functional following blood pressure measurement and its application to novel diagnosis of atherosclerosis

2014 - 2016 Development of a novel apparatus for evaluation of arterial stiffness of the brachial artery in the extra-physiological pressure range and its application for early diagnosis of atherosclerosis

2014 - 2016 Biomechanical study for controlling cell functions by manipulating the nuclear mechanical environment.

2010 - 2016 Management of the research group on logic for biological pattern formation

2010 - 2015 Establishment of visualization of stress distribution in cells and tissues toward understanding of morphogenesis from biomechanical viewpoint

2012 - 2014 Visualization of atherosclerosis: Quantitative evaluation of degree of atherosclerosis by separate measurement of endothelial function and smooth muscle function

2012 - 2014 Endothelial damage caused by blood pressure measurement? Study on decrease in endothelium function following cuff occlusion and its application to diagnosis of atherosclerosis

2012 - 2014 Direct manipulation of the intracellular stress distribution for controlling cell division

2012 - 2014 Rupture risk estimation of individual aortic aneurysms based on data collected in in vivo mechanical condition

2010 - 2014 Biomechanical and biochemical analyses of biological tissues in a microscopic level for unified understanding of mechanical adaptation mechanism of biological tissues

2010 - 2011 Control of cell functions by mechanical stimulation of cell nuclei

2010 - 2011 Molecular cell biomechanical analysis of novel pharmacological activity of monosaccharide

2009 - 2010 機能的組織構築を目指した培養基板力学特性の空間分布操作による細胞挙動制御

2008 - 2009 血管内皮細胞における糖鎖メカノセンサーの探索

2007 - 2009 Establishment of microscopic analysis method of stress and strain fields in the biological tissues for unified understanding of mechanical adaptation mechanism from cells to tissues

2007 - 2008 骨の力学的適応現象の解明を目指した骨組織形成過程のその場観察系の確立

2007 - 2008 細胞分裂機構の解明を目指した細胞焦点接着斑力学刺激負荷デバイスの開発

2003 - 2007 Biomechanics at Micro- and Nanoscale Levels

2005 - 2006 細胞の力学的適応を利用した荷重支持構造物の自発的創成

2004 - 2006 Measurement of mechanical properties of vascular smooth muscle and blood vessel wall as a model of functional materials

2003 - 2006 Measurement of mechanical properties of cells based on their internal structures

2005 - 2005 アジア・太平洋バイオメカニクス学会の設立のための企画調査

2002 - 2004 Roles of Integrins of Endothelial Cells in Response to Mechanical Stimuli

2002 - 2003 マイクロ角度センサアレイを用いた微小癌触診用小型硬さ分布測定プローブの開発

2002 - 2003 細胞による荷重支持構造物の自発的創成に関する研究

2001 - 2003 Measurement of mechanical properties of vascular smooth muscle cells as a model of functional materials

2000 - 2002 Development of a cell rotation sytem for the observation of 3D microstructure of cells

2000 - 2001 魚の側線感覚細胞はせん断速度センサとなりうるか?

2000 - 2001 Development of Atomic Force Microscope System Combined with Confocal Laser Scanning Microscope to Simultaneously Measure Mechanical Stiffness and Observe Microstructure of Cultured Cells

1999 - 2000 Measurement of intramural stress and strain distributions in the atherosclerotic arteries considering the complexity of the lesion

1999 - 2000 Molecular Biological and Biomechanical Approach to Aortic Aneurysm

1998 - 1999 流れ負荷時の培養内皮細胞内αーアクチニンの実時間挙動解析

1998 - 1999 Development of Atomic Force Microscope System Combined with Confocal Laser Scanning Microscope to Simultaneously Measure Mechanical Stiffness and Observe Microstructure of Cultured Cells

1998 - 1999 Biomechanical Analysis of Aortic Aneurysm Failure to Find Out the Important Factors

1997 - 1999 Development of a micro tensile tester for the in-process monitoring of cell structure

1997 - 1998 血管壁内3次元応力・ひずみ分布に対する平滑筋収縮の影響の解析

1996 - 1998 Analysis of the aortic wall motion by SPAMM tagging method.

1996 - 1997 Study on localization of atherogenesis

1995 - 1997 Development of Diagnosis System for Atherosclerosis Based on the Autofluorescence of Blood and Vascular Walls

1995 - 1997 Vascular Endothelial Cell Response to Mechanical Stimuli

1996 - 1996 血管壁内応力分布に対する平滑筋収縮の影響の解析

1995 - 1995 血管壁内ひずみ分布に対する血管平滑筋収縮の影響のバイオメカニクス的解析

1994 - 1994 血管壁内残留ひずみに対する血管平滑筋の影響のバイオメカニクス的検討

1994 - 1994 高血圧に伴う血管壁のリモデリング機構解明のための摘出血管の人工培養システム

1994 - 1994 血管壁断面内の異方性弾性率分布の測定

1993 - 1993 高血圧に伴う血管壁のリモデリング機構解明のための摘出血管の人工培養システム

1993 - 1993 血管壁断面内の異方性弾性率分布の測定

1992 - 1993 Effects of derection and pulsatility of flow on morphology and functions of cultured endothelial cells

1992 - 1992 生体軟組識の力学的性質と構成法則に関する研究

1991 - 1992 Development and Evaluation of Multiaxial and Dynamic Material Test System for Biological Tissues and Biomaterials

1991 - 1991 血管内流れの解明を目的としたレーザドップラ流速計による弾性管内拍動流の解析

1990 - 1991 Biomechanics on the Growth and Deformation of Living Tissues and its Applications to Engineering

1990 - 1990 血管内流れの解明を目的とした流れの可視化による弾性管内拍動流の解析

1989 - 1990 Biomechanics on the Growth and Deformation of Living Tissues and its Applications to Engineering

1989 - 1989 血管内流れの解明を目的とした流れの可視化による弾性管内拍動流の計測

1988 - 1989 Study on the mechanical effects of cardiac assist by implantable sono-micrometer

生体組織・細胞の力学的応答

楽器演奏のバイオメカニクス

皮膚のバイオメカニクス

細胞内微細構造観察装置の開発

生体軟組織・細胞の力学特性計測と応力・ひずみ分布解析

Mechanical Response of Biological Tissues and Cells

Biomechanics on playing musical instruments

Skin Biomechanics

Development of an observation system for intracellular microstructure

Measurement of Mechanical Properties and stress/strain analysis of Soft Biological Tissues and cells