Rchr
J-GLOBAL ID：200901067063367694   Update date: Apr. 13, 2024

HATTORI Yoshiyuki

ハットリ ヨシユキ | HATTORI Yoshiyuki
Affiliation and department：
Hoshi University Department of Molecular Pharmaceutics

About Hoshi University Department of Molecular Pharmaceutics


Job title： Professor
Homepage URL  (2)： https://www.hoshi.ac.jp/laboratory/yakuzaigaku/ ,  https://jupiter.hoshi.ac.jp/lab/yakuzai/hattori%20(E).htm
Research field  (1)： Clinical pharmacy
Research keywords  (6)： Liposome ,  Gene therapy ,  Nucleic acids-based therapeutics ,  Gene delivery ,  Tumor therapy ,  Drug delivery system
Research theme for competitive and other funds  (14)：
  • 2024 - 2027 Development of mRNA lipid nanoparticles for tumor vaccine
  • 2020 - 2023 静脈内投与によりがん組織へsiRNAを送達するための葉酸修飾リポソーム製剤の開発
  • 2017 - 2020 Development of siRNA therapy for liver metastasis by sequential injection of chondroitin sulfate and siRNA lipoplex
  • 2014 - 2017 siRNA delivery to cancer tissue by sequential injection of anionic polymer and siRNA lipoplex
  • 2012 - 2015 Development of PEGylated Histone Deacetylase Inhibitor Having Prolonged Blood Retention and EPR effect
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Papers (112)：
  • Yoshiyuki Hattori, Min Tang, Aya Aoki, Momoka Ezaki, Hana Sakai, Kei-Ichi Ozaki. Effect of the combination of cationic lipid and phospholipid on gene-knockdown using siRNA lipoplexes in breast tumor cells and mouse lungs. Molecular Medicine Reports. 2023. 28. 4
  • Kumi Kawano, Ayami Furuya, Yuri Matsuda, Chisato Kimura, Kotono Yamaguchi, Sakura Wakabayashi, Kotone Taniguchi, Kei-ichi Ozaki, Yoshiyuki Hattori. Preparation of liposomes co-encapsulating doxorubicin and mifepristone for treating multidrug-resistant cancer. Journal of Drug Delivery Science and Technology. 2023. 85. 104605
  • Min Tang, Ayane Sagawa, Nodoka Inoue, Satomi Torii, Kana Tomita, Yoshiyuki Hattori. Efficient mRNA Delivery with mRNA Lipoplexes Prepared Using a Modified Ethanol Injection Method. Pharmaceutics. 2023. 15. 4. 1141
  • Min Tang, Sho Sakasai, Hiraku Onishi, Kumi Kawano, Yoshiyuki Hattori. Effect of PEG anchor in PEGylation of folate-modified cationic liposomes with PEG-derivatives on systemic siRNA delivery into the tumor. Journal of Drug Targeting. 2023. 31. 1. 74-88
  • Yoshiyuki Hattori, Hiromu Saito, Kayo Nakamura, Ayaka Yamanaka, Min Tang, Kei-ichi Ozaki. In vitro and in vivo transfections using siRNA lipoplexes prepared by mixing siRNAs with a lipid-ethanol solution. Journal of Drug Delivery Science and Technology. 2022. 75. 103635
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MISC (14)：
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Patents (6)：
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Books (5)：
  • 遺伝子治療・診断の最先端技術と新しい医薬品・診断薬の開発
    技術情報協会 2014
  • The Drug Delivery System
    2012
  • Encyclopedia of Nanoscience and Nanotechnology, edited by H. S. Nalwa
    American Scientific Publishers 2011
  • Oral Cancer Research Advances, edited by Alexios P. Nikolakakos
    Nova Science Publishers, Inc. 2007
  • Nanotechnologies for the Life Science, Biofunctionalization of nanomaterials, edited by Challa. Kumar
    Wiley-VCH 2005
Lectures and oral presentations  (213)：
  • 脂質エタノール溶液とmRNA溶液の混合のみにより調製したmRNAリポプレックス投与後のin vitroおよびin vivoでのタンパク質発現効果の検討
    (日本DDS学会学術集会プログラム予稿集 2023)
  • Evaluation of protein expression in cultured cells with mRNA lipoplexes prepared by simply mixing of mRNA solution with a lipid ethanol solution
    (日本薬剤学会年会講演要旨集(CD-ROM) 2023)
  • 脂質エタノール溶液を用いた修正エタノール注入法により調製したsiRNAリポプレックス投与後のがん細胞およびマウス肺での遺伝子発現抑制効果
    (日本薬学会関東支部大会講演要旨集 2022)
  • 正電荷リポソーム組成の正電荷脂質とリン脂質の組み合わせが及ぼすsiRNAリポプレックス投与後の培養細胞およびマウス肺での遺伝子発現抑制効果の影響
    (日本薬学会関東支部大会講演要旨集 2022)
  • 葉酸修飾siRNAリポプレックスのPEG修飾に用いるPEG誘導体のアンカー部が及ぼすマウス生体内分布および抗腫瘍効果の影響
    (日本DDS学会学術集会プログラム予稿集 2022)
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Education (1)：
  • 1996 - 1999 Kyoto University Graduate School of Pharmaceutical Science
Professional career (1)：
  • Doctor (Kyoto University)
Work history (9)：
  • 2020/04 - 現在 Hoshi University Department of Molecular Pharmaceutics Professor
  • 2019/08 - 2020/03 Hoshi University Department of Pharmaceutics Professor
  • 2018/01 - 2019/07 Hoshi University Department of Drug Delivery Research Professor
  • 2015/04 - 2017/12 Hoshi University Department of Drug Delivery Research Associate Professor
  • 2009/05 - 2015/03 Hoshi University Institute of Medicinal Chemistry Associate professor
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Committee career (2)：
  • 2023/02 - 現在 日本薬学会関東支部 幹事
  • 2018/04 - 現在 日本薬剤学会 代議員
Awards (5)：
  • 2019/03 - European Conference on Pharmaceutics JDDST 2018 Best paper award
  • 2009/10 - The Pharmaceutical Society of Japan Kanto Branch Award for Young Scientists
  • 2009/05 - 星薬科大学 大谷記念研究助成金 脂質ナノ粒子を用いた癌遺伝子治療法の開発
  • 2001/07 - The Japan Endocrine Society Young Investigator Awards
  • 1999/09 - American Thyroid Association Travel Grant
Association Membership(s) (3)：
日本薬剤学会 ,  日本薬学会 ,  日本DDS学会
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