Rchr
J-GLOBAL ID:200901068471356290   Update date: Mar. 07, 2024

Irimura Tatsuro

イリムラ タツロウ | Irimura Tatsuro
Affiliation and department:
Job title: 特任教授
Homepage URL  (1): http://www.f.u-tokyo.ac.jp/~cancer/labpage/index.html
Research field  (4): Pathobiochemistry ,  Pharmacology ,  Pharmaceuticals - health and biochemistry ,  Structural biochemistry
Research keywords  (6): 糖鎖生物学 ,  腫瘍生物学 ,  分子免疫学 ,  Glycobiology ,  Cancer Biology ,  Molecular Immunology
Research theme for competitive and other funds  (48):
  • 2014 - 2018 Development of cancer stem cells driven by microenvironment
  • 2013 - 2017 MUC21 glycoforms as the target of cancer diagnosis and therapy
  • 2012 - 2015 Regulation of IgA responses against influenza virus
  • 2009 - 2013 Immune-suppressive function of cancer-associated mucin epiglycanin/Muc21
  • 2010 - 2011 A peptide sequence motif which regulates glycoforms
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Papers (260):
  • Yoshiya Horimoto, May Thinzar Hlaing, Harumi Saeki, Kaori Denda-Nagai, Katrin Ishii-Schrade, Haruhiko Fujihira, Masaaki Abe, Miki Noji, Shigeyuki Shichino, Mitsue Saito, et al. Glycosylation profiles of breast cancer cells may represent clonal variations of multiple organ metastases. Clinical & experimental metastasis. 2024
  • Yukari Manome-Zenke, Kaori Denda-Nagai, Ryuichi Murakami, Miki Noji, Naoto Tsuneda, Katrin Beate Ishii-Schrade, Naoki Kanomata, Satoru Arai, Tatsuro Irimura, Shigaku Ikeda. Possible Involvement of Antigen-Presenting Cells Expressing the Macrophage Galactose-Type C-Type Lectin in Inflammatory Skin Diseases. The Journal of investigative dermatology. 2023. 143. 9. 1834-1838
  • Ryoko Semba, Yoshiya Horimoto, Madoka Sakata-Matsuzawa, Yumiko Ishizuka, Kaori Denda-Nagai, Haruhiko Fujihira, Miki Noji, Hiroko Onagi, Miyu Ichida, Hiroyoshi Miura, et al. Possible correlation of apical localization of MUC1 glycoprotein with luminal A-like status of breast cancer. Scientific reports. 2023. 13. 1. 5281-5281
  • May Thinzar Hlaing, Yoshiya Horimoto, Kaori Denda-Nagai, Haruhiko Fujihira, Miki Noji, Hiroyuki Kaji, Azusa Tomioka, Yumiko Ishizuka, Harumi Saeki, Atsushi Arakawa, et al. Tamoxifen-resistant breast cancer cells exhibit reactivity with Wisteria floribunda agglutinin. PLOS ONE. 2022. 17. 8. e0273513-e0273513
  • Ryoka Kokubu, Shiho Ohno, Hirohide Kuratani, Yuka Takahashi, Noriyoshi Manabe, Hiroki Shimizu, Yasunori Chiba, Kaori Denda-Nagai, Makoto Tsuiji, Tatsuro Irimura, et al. O-Glycan-Dependent Interaction between MUC1 Glycopeptide and MY.1E12 Antibody by NMR, Molecular Dynamics and Docking Simulations. International Journal of Molecular Sciences. 2022. 23. 14. 7855-7855
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MISC (386):
  • 岡崎 みさと, 堀本 義哉, 松澤 円佳, 中井 克也, 齊藤 光江, 入村 達郎. トリプルネガティブ乳癌におけるベータ-3-N-アセチルガラクトサミン転移酵素の臨床病理学的重要性. 日本乳癌学会総会プログラム抄録集. 2021. 29回. 105-105
  • 松澤 円佳, 堀本 義哉, 岡崎 みさと, 中井 克也, 齊藤 光江, 入村 達郎. 手術検体を用いたレクチンアレイ分析によって明らかになったTNBCの再発しやすい亜集団に特有な糖鎖. 日本乳癌学会総会プログラム抄録集. 2021. 29回. 325-325
  • 史 佳, 生田 駿乃介, 福村 修示, 大熊 晴香, 鈴木 聖也, 金田 碧, 福田 明々人, 重田 奈緒, 高橋 勝彦, 奥 輝明, et al. ヘパラナーゼ阻害物質heparastatin(SF4)による結腸癌細胞の増殖抑制効果. 日本薬学会年会要旨集. 2021. 141年会. 27P02-084S
  • 徐 暁雨, 玉田 裕, 山下 諒子, 鈴木 明日美, 古市 紗都, 野本 莉紗, 高橋 勝彦, 中島 元夫, 入村 達郎, 東 伸昭. リンパ節転移能を有する卵巣癌細胞株におけるヘパラナーゼの発現と機能の解析. 日本薬学会年会要旨集. 2021. 141年会. 27P02-083S
  • 浜田 真美加, 山本 陽香, 高橋 勝彦, 小林 恒雄, 中島 元夫, 入村 達郎, 東 伸昭. ヘパラナーゼは結腸癌細胞によるエクソソーム分泌を調節する. 日本薬学会年会要旨集. 2021. 141年会. 28P02-091S
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Patents (12):
Works (4):
  • 特許:ヘパラナ-ゼ阻害物質によるがんの抑制
    1991 -
  • Patent (US, European, Japanese, Canadian) Prevention of cancer growth by heparanase inhibitors
    1991 -
  • 特許:エンドグリコシダ-ゼ検出法
    1987 -
  • Patent (US, European, Japanese, Canadian) Endoglycosidare assay
    1987 -
Education (2):
  • 1971 - 1974 The University of Tokyo Graduate School of Pharmaceutical Sciences
  • 1967 - 1971 The University of Tokyo Faculty of Pharmaceutical Sciences
Professional career (3):
  • (BLANK)
  • (BLANK)
  • Ph.D
Work history (10):
  • 2022/04 - 現在 Juntendo University Medical School Department of Breast Oncology Visiting Professor
  • 2016/02 - 2022/03 Juntendo University Graduate School of Medicine・Faculty of Medicine Project Professor
  • 2015/04 - 2016/01 Juntendo University Graduate School of Medicine Visiting Professor
  • 2014/04 - 2015/03 St. Luke's International University Institute of Medical Innovation Director
  • 2013/04 - 2014/03 St. Luke's International Hospital Institute of Medical Innovation Director
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Committee career (8):
  • 2016/09 - 2020/09 International Pharamceutical Federation Chair of Board of Pharmaceutical Sciences
  • 2012/06 - 2016/03 Pharmaceutical and Medical Devise Agency Chair of Science Board
  • 2012/04 - 2016/03 Science Council of Japan Adjunct member
  • 1998 - 2004 Metastasis Research Society Board Member
  • 1997 - 2000 Ministry of Health Member of Health Science Committee
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Awards (3):
  • 2014/04 - 5th Pharmaceutical Science World Congress Recognition Award
  • 2013/09 - International Pharmaceutical Federation FIP Fellow
  • 2010/03 - Pharmaceutical Socierty of Japan Pharmaceutical Society Award
Association Membership(s) (7):
International Pharmaeutical Federation ,  国際癌転移研究会 ,  アメリカ癌学会 ,  日本免疫学会 ,  日本癌学会 ,  日本薬学会 ,  日本生化学会
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