Rchr
J-GLOBAL ID:200901068471356290
Update date: Mar. 07, 2024
Irimura Tatsuro
イリムラ タツロウ | Irimura Tatsuro
Affiliation and department:
Job title:
特任教授
Homepage URL (1):
http://www.f.u-tokyo.ac.jp/~cancer/labpage/index.html
Research field (4):
Pathobiochemistry
, Pharmacology
, Pharmaceuticals - health and biochemistry
, Structural biochemistry
Research keywords (6):
糖鎖生物学
, 腫瘍生物学
, 分子免疫学
, Glycobiology
, Cancer Biology
, Molecular Immunology
Research theme for competitive and other funds (48):
- 2014 - 2018 Development of cancer stem cells driven by microenvironment
- 2013 - 2017 MUC21 glycoforms as the target of cancer diagnosis and therapy
- 2012 - 2015 Regulation of IgA responses against influenza virus
- 2009 - 2013 Immune-suppressive function of cancer-associated mucin epiglycanin/Muc21
- 2010 - 2011 A peptide sequence motif which regulates glycoforms
- 2006 - 2007 ガラクトース型C型レクチンによる消化器癌転移の制御とその診断への応用
- 2006 - 2007 Regulation of extracellular matrix structure as a biological response to chemical stimuli and irradiation
- 2005 - 2006 ヘパラナーゼの局在化によるヘパラン硫酸分解活性の制御と生体内の細胞交通の制御
- 2005 - 2005 大腸癌肝転移形成におけるレクチンを介する接着と増殖の制御
- 2004 - 2005 Chemical-induced hypersensitivity, cellular mechanism and its regulation
- 2003 - 2004 ヘパラナーゼの局在化による機能調節:マクロファージ及び類縁細胞における役割
- 2002 - 2004 スキルス胃癌での粘液糖蛋白発現と腹膜播種-MUC1ムチンと糖転移酵素に着目して
- 2000 - 2004 マウスモデルに基づくヒト大腸癌転移形質のバイオインフォーマティックスによる解析
- 2001 - 2003 Mucin glycoproteins in human gallbladder carcinoma and their biological effects on tumor invasion and metastasis capability.
- 2000 - 2003 Structural diversity of mucins : Significance in infection and immunity
- 2001 - 2002 Molecular analyzes of sensitization phase of contact hypersensitivity
- 2001 - 2002 細胞治療に用いる細胞のレクチンライブラリーによる同定と評価
- 1999 - 2002 Establishment of hepatic metastasis model of pancreatic carcinoma and it application to the development of therapeutic agents
- 1999 - 2000 Molecular mechanisms of cancer cell progression during liver metastasis formation
- 1997 - 1999 宿主を重視した転移の分子生物学
- 1998 - 1998 組織の線維化の分子細胞生物学的研究
- 1998 - 1998 加齢病態・疾病発病に関わる神経・免疫・内分泌相関の細胞分子・医療薬学的研究
- 1997 - 1998 Structure and function of a variation of sialyl Lewis X carbohydrate chains on glycoproteins.
- 1995 - 1998 Regulation of cellular trafficking and pathogenesis by mucins
- 1997 - 1997 糖鎖遺伝子とその生物機能
- 1996 - 1996 糖鎖による分子認識と接着
- 1996 - 1996 がんの進展・転移に関与する糖鎖情報
- 1995 - 1996 Development of anti-metastatic agents related to the early event of metastasis : screened by novel imaging thchnique.
- 1995 - 1996 Study of factors that regulates site-specific brain metastasis
- 1994 - 1996 Development of anti-inflammatory drugs affecting functions of platelet adhesion molecules
- 1995 - 1995 がんの進展・転移に関与する糖鎖情報
- 1993 - 1995 Establishment of Detection Systems and Expression Systems for Organ-Specific Mucins
- 1994 - 1994 がんの進展・転移に関与する糖鎖情報
- 1994 - 1994 VLAインテグリンを介したがん細胞の接着と運動
- 1993 - 1993 糖鎖の細胞認識と癌の進展,特性に関する研究
- 1993 - 1993 がん転移に関与する分子とその制御機構
- 1993 - 1993 VLAインテグリンを介したがん細胞運動性の制御
- 1992 - 1993 Cell surface glycoconjugates and adhesion molecules
- 1991 - 1993 New Development in glycobiology
- 1992 - 1992 糖鎖の細胞認識と癌の進展、特性の研究
- 1992 - 1992 がん転移に関与する分子とその制御機構
- 1992 - 1992 糖鎖遺伝子とその生物活性
- ムチン
- がん転移
- マクロファ-ジの分子免疫学
- Mucins
- Cancer Metastasis
- Molecular and Cell Biology of Macrophages
Show all
Papers (260):
-
Yoshiya Horimoto, May Thinzar Hlaing, Harumi Saeki, Kaori Denda-Nagai, Katrin Ishii-Schrade, Haruhiko Fujihira, Masaaki Abe, Miki Noji, Shigeyuki Shichino, Mitsue Saito, et al. Glycosylation profiles of breast cancer cells may represent clonal variations of multiple organ metastases. Clinical & experimental metastasis. 2024
-
Yukari Manome-Zenke, Kaori Denda-Nagai, Ryuichi Murakami, Miki Noji, Naoto Tsuneda, Katrin Beate Ishii-Schrade, Naoki Kanomata, Satoru Arai, Tatsuro Irimura, Shigaku Ikeda. Possible Involvement of Antigen-Presenting Cells Expressing the Macrophage Galactose-Type C-Type Lectin in Inflammatory Skin Diseases. The Journal of investigative dermatology. 2023. 143. 9. 1834-1838
-
Ryoko Semba, Yoshiya Horimoto, Madoka Sakata-Matsuzawa, Yumiko Ishizuka, Kaori Denda-Nagai, Haruhiko Fujihira, Miki Noji, Hiroko Onagi, Miyu Ichida, Hiroyoshi Miura, et al. Possible correlation of apical localization of MUC1 glycoprotein with luminal A-like status of breast cancer. Scientific reports. 2023. 13. 1. 5281-5281
-
May Thinzar Hlaing, Yoshiya Horimoto, Kaori Denda-Nagai, Haruhiko Fujihira, Miki Noji, Hiroyuki Kaji, Azusa Tomioka, Yumiko Ishizuka, Harumi Saeki, Atsushi Arakawa, et al. Tamoxifen-resistant breast cancer cells exhibit reactivity with Wisteria floribunda agglutinin. PLOS ONE. 2022. 17. 8. e0273513-e0273513
-
Ryoka Kokubu, Shiho Ohno, Hirohide Kuratani, Yuka Takahashi, Noriyoshi Manabe, Hiroki Shimizu, Yasunori Chiba, Kaori Denda-Nagai, Makoto Tsuiji, Tatsuro Irimura, et al. O-Glycan-Dependent Interaction between MUC1 Glycopeptide and MY.1E12 Antibody by NMR, Molecular Dynamics and Docking Simulations. International Journal of Molecular Sciences. 2022. 23. 14. 7855-7855
more...
MISC (386):
-
岡崎 みさと, 堀本 義哉, 松澤 円佳, 中井 克也, 齊藤 光江, 入村 達郎. トリプルネガティブ乳癌におけるベータ-3-N-アセチルガラクトサミン転移酵素の臨床病理学的重要性. 日本乳癌学会総会プログラム抄録集. 2021. 29回. 105-105
-
松澤 円佳, 堀本 義哉, 岡崎 みさと, 中井 克也, 齊藤 光江, 入村 達郎. 手術検体を用いたレクチンアレイ分析によって明らかになったTNBCの再発しやすい亜集団に特有な糖鎖. 日本乳癌学会総会プログラム抄録集. 2021. 29回. 325-325
-
史 佳, 生田 駿乃介, 福村 修示, 大熊 晴香, 鈴木 聖也, 金田 碧, 福田 明々人, 重田 奈緒, 高橋 勝彦, 奥 輝明, et al. ヘパラナーゼ阻害物質heparastatin(SF4)による結腸癌細胞の増殖抑制効果. 日本薬学会年会要旨集. 2021. 141年会. 27P02-084S
-
徐 暁雨, 玉田 裕, 山下 諒子, 鈴木 明日美, 古市 紗都, 野本 莉紗, 高橋 勝彦, 中島 元夫, 入村 達郎, 東 伸昭. リンパ節転移能を有する卵巣癌細胞株におけるヘパラナーゼの発現と機能の解析. 日本薬学会年会要旨集. 2021. 141年会. 27P02-083S
-
浜田 真美加, 山本 陽香, 高橋 勝彦, 小林 恒雄, 中島 元夫, 入村 達郎, 東 伸昭. ヘパラナーゼは結腸癌細胞によるエクソソーム分泌を調節する. 日本薬学会年会要旨集. 2021. 141年会. 28P02-091S
more...
Patents (12):
Works (4):
-
特許:ヘパラナ-ゼ阻害物質によるがんの抑制
1991 -
-
Patent (US, European, Japanese, Canadian) Prevention of cancer growth by heparanase inhibitors
1991 -
-
特許:エンドグリコシダ-ゼ検出法
1987 -
-
Patent (US, European, Japanese, Canadian) Endoglycosidare assay
1987 -
Education (2):
- 1971 - 1974 The University of Tokyo Graduate School of Pharmaceutical Sciences
- 1967 - 1971 The University of Tokyo Faculty of Pharmaceutical Sciences
Professional career (3):
Work history (10):
- 2022/04 - 現在 Juntendo University Medical School Department of Breast Oncology Visiting Professor
- 2016/02 - 2022/03 Juntendo University Graduate School of Medicine・Faculty of Medicine Project Professor
- 2015/04 - 2016/01 Juntendo University Graduate School of Medicine Visiting Professor
- 2014/04 - 2015/03 St. Luke's International University Institute of Medical Innovation Director
- 2013/04 - 2014/03 St. Luke's International Hospital Institute of Medical Innovation Director
- 1991/07 - 2013/03 The University of Tokyo Graduate School of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences Professor
- 1988/07 - 1991/07 The University of Texas MD Anderson Cancer Center Department of Tumor Biology Associate Professor with tenure
- 1980/09 - 1988/06 The University of Texas MD Anderson Cancer Center Department of Tumor Biology Assistant Professor
- 1980/02 - 1980/08 University of California at Irvine Developmental and Cell Biology Postgraduate Research Assistant
- 1974/10 - 1980/01 The University of Tokyo 薬学部 Assistant Professor
Show all
Committee career (8):
Awards (3):
- 2014/04 - 5th Pharmaceutical Science World Congress Recognition Award
- 2013/09 - International Pharmaceutical Federation FIP Fellow
- 2010/03 - Pharmaceutical Socierty of Japan Pharmaceutical Society Award
Association Membership(s) (7):
International Pharmaeutical Federation
, 国際癌転移研究会
, アメリカ癌学会
, 日本免疫学会
, 日本癌学会
, 日本薬学会
, 日本生化学会
Return to Previous Page