Hanada Nobuhiro

2019 - 2022 摂食機能評価に基づいた栄養食事指導の有効性と体組成改善への影響の検討

2019 - 2022 脳卒中発症に寄与するStreptococcus mutansの病原因子解明

2018 - 2021 Development of Calcium Ion Sustained Release Dental Materials Contributing to the Prevention and Healing of Soft Tissue Diseases

2018 - 2021 Study of prevention of orthodontically induced root resorption; focusing on the role of HSP72.

2018 - 2021 Studies on the accumulation of 90Sr emitted from Fukushima No.1 Nuclear Power Plant accident into human milk teeth

2018 - 2021 Development of a new preventive method for root caries using lipid oxide and its application to fluoride combination therapy

2018 - 2021 酸化脂質を用いた新しい根面齲蝕の予防方法の開発とフッ化物併用療法への応用

2017 - 2020 Establishment of the systematic oral management for oral complications in the hematopoietic stem cells transplantation.

2017 - 2020 Role of oral-care in inflammatory bowel disease patients in remission: an oral and intestinal bacteria-based study

2017 - 2020 Analysis of healthy oral microbiome

2017 - 2020 Effect of Periodontal Health Promotion on Improvement of Endothelial Function: A Randomized Clinical Trial

2017 - 2020 Antibacterial and oral malodour supressing effects of black cumin food materials and elucidation of these mechanisms

2016 - 2020 Challenging to development of pre-emptive dementia prevention method.

2016 - 2019 On the masticatory function recovery by dental prostheses and the improvement of body composition and metabolic parameters

2015 - 2019 Study on the accumulation of human milk teeth released radioactive nuclides by the Fukushima nuclear power plant accident

2015 - 2018 Elucidation of the role of oral-derived endotoxin as a common risk factor for periodontal disease and dementia

2014 - 2017 The effect of HSPA1A on the rate of orthodontic tooth movement.

2013 - 2016 Identification of fluoride transporter that contribute to fluoride resistance in Streptococcus mutans

2013 - 2016 Studies on the adherence factors of mutans streptococci to human oral cavity by comparative investigation among primates

2012 - 2015 New concept of periodontal disease as a life-style related disease

2012 - 2015 Detection method to the oral normal flora with resistance on innate immunity for prevention of aspiration pneumonia.

2012 - 2015 Analysis of gram-positive/negative bacteria ratio and pathogenicity of oral biofilm

2012 - 2015 The relationship between oral health and medical expenses

2012 - 2015 唾液検査とレセプト電算処理システムに基づく新たな口腔と全身状態の関係解明の試み

2011 - 2013 Function of immunocompetent cells in the tension zone of periodontal ligament in tooth movement

2011 - 2013 development of new oral care system utilizing detection of bacteria related with influenza infection as an index

2011 - 2013 The molecular epidemiologic analysis of the mechanism of calculus formation: Role of the bacteria exist in saliva

2010 - 2012 Effects of probiotics in human evolutional model

2009 - 2011 リポソーム法を用いた口腔粘膜細胞からのiPS細胞作製技術の確立

2009 - 2011 iPS細胞の臨床応用における歯科医療安全に関する基礎研究と安全評価方法の検討

2009 - 2011 Basic study to address safety issue of human iPS cells for dental practice

2009 - 2011 Human iPS cells from oral mucosal tissues using the liposome non-viral gene delivery system

2009 - 2011 Construction of mutanase chimer ic enzyme by domain shuffling and degradation of biofilm by the chimeric enzyme

2009 - 2011 Establishment of artificial synthesis of Nano bacteria and dental calculus

2008 - 2011 成人期における歯科疾患のスクリーニング体制の構築に関する研究

2007 - 2009 Metabolome analysis of oral biofilm using CE-TOFMS and its application possibility as an oral health indicator

2007 - 2008 石灰化ナノ粒子(CNPs)による初期齲蝕再石灰化の試み

2007 - 2008 Establishment o f the methodology for the evaluation of the of the de-and re-mineralization by the QLF and ICDAS

2006 - 2008 石灰化ナノ粒子(CNPs)による初期齲蝕再石灰化の試み

2004 - 2006 Studies on Secondary Caries Initiation Mechanism and Finding Prevention Methods Using a Newly Modified Oral Biofilm Reactor

2003 - 2005 Molecular analyses and identifications of new genes to infectious diseases relating with oral biofilm

2003 - 2005 Development of a caries risk assessment system using genetic polymorphisms influencing cariogenicities of mutans streptococci.

2002 - 2003 Probiotics for the preventive dentistry and oral infectious Deseases

2001 - 2002 Study of susceptibility genes for oral infectious diseases relating to biofilm in elderly

2000 - 2002 Establishment of new system to prevent oral infectious diseases relating to oral biofilm

2000 - 2001 Studies on the development of the periodontal examination by using saliva

1999 - 2001 ANALYSIS OF ANTI-MICROBIAL FACTORS OF SALIVA IN ELDERLY

1998 - 2001 Study on health

1999 - 1999 正常口腔細菌叢移行のための植物抗体生産系の確立

1995 - 1997 Study of a new medicine of caries prevention

1992 - 1992 歯周病セルフチェックの開発とその有効性の評価

1989 - 1991 mutans streptococciのグルカン合成酵素を用いた齲蝕ワクチンの開発

1990 - 1990 Bacteroides gingivalisのプロテアーゼ遺伝子のクローニング

1986 - 1986 新たに分離した1,6-α-D-glucan synthaseのう蝕ワクチン利用

Preventive Dentistry

歯周病と認知症の共通リスク因子としての口腔由来エンドトキシンの役割の解明