Rchr
J-GLOBAL ID：200901073238384074
Update date: Apr. 01, 2024
Fujii Shinya
フジイ シンヤ | Fujii Shinya
Affiliation and department：
Research field (5)：
Chemical biology
, Functional solid-state chemistry
, Pharmaceuticals - chemistry and drug development
, Bioorganic chemistry
, Structural/physical organic chemistry
Research keywords (5)：
Functional Molecules
, Medicinal Elements Chemistry
, Chemical biology
, Medicinal chemistry
, Organic chemistry
Research theme for competitive and other funds (14)：
- 2019 - 2022 創薬化学の第3のアミド~リン酸アミドが創る新しいケミカルスペースと生物機能性分子
- 2017 - 2022 画期的な医薬分子設計を支援する多元素創薬化学の基盤構築
- 2020 - 細胞増殖シグナル制御化合物と受容体の分子間相互作用の解明
- 2020 - ホスフィンボラン構造を用いた新規ケミカルスペースの開拓と生物活性化合物の創出法の提案
- 2016 - 2018 -
- 2014 - 2017 Polypharmacology based on dynamism of the target protein
- 2013 - 2016 生理活性天然物のファーマコフォア再構築による転写機能調節化合物の創製
- 2010 - 2015 Development of specific modulators for nuclear receptors and elucidation of their functions
- 2011 - 2013 高周期14族元素の生理活性分子疎水性フラグメントとしての展開
- 2011 - 2013 Development of novel vitamin K derivatives and elucidation of their biological functions
- 2008 - 2012 Development of Receptor Regulators Utilizing Novel HydrophobicStructure and Its Application for Medicinal Drug Design
- 2009 - 2011 新規疎水性骨格の開発を基盤とした非セコステロイド型ビタミンD受容体リガンドの創製
- 2008 - 2009 ホウ素クラスターを骨格構造として用いた新規核内受容体機能調節剤の創薬化学研究
- 2006 - 2007 ホウ素クラスターの特異な性質を利用した、新規分子標的制癌化合物の創製研究
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Papers (81)：
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Miyajima, Y, Ochiai, K, Fujii, S. Design, synthesis, and evaluation of B-(trifluoromethyl)phenyl phosphine-borane derivatives as novel progesterone receptor antagonists. Molecules. 2024
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Kotaro Ochiai, Ryo Yonezawa, Shinya Fujii. Structural Development of Androgen Receptor Antagonists Using Phenylferrocene Framework as a Hydrophobic Pharmacophore. ChemMedChem. 2024. 19. 6. e202400040
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Yu Miyajima, Tomomi Noguchi-Yachide, Kotaro Ochiai, Shinya Fujii. Physicochemical characterization of B-hydroxyphenyl phosphine borane derivatives and their evaluation as nuclear estrogen receptor ligands. RSC Medicinal Chemistry. 2024. 15. 1. 119-126
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Yuichiro Matsumoto, Yuichi Hashimoto, Shinya Fujii. Development of subtype-selective estrogen receptor modulators using the bis(4-hydroxyphenyl)silanol core as a stable isostere of bis(4-hydroxyphenyl)methanol. RSC Advances. 2023. 13. 39. 27359-27362
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Kimiko Tanaka, Fumi Takeda, Midori Kanda, Masatoshi Kawahata, Shinya Fujii, Kosuke Katagiri, Hyuma Masu, Hiroyuki Kagechika, Aya Tanatani. Solvent-Dependent Conformational Switching of N-Methyl-N,N′-diarylsquaramide. The Journal of Organic Chemistry. 2023. 88. 17. 12289-12293
ｍore...
MISC (25)：
Patents (3)：
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ニ環性ピリミジン誘導体
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複素環式化合物
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新規アンドロゲン受容体アンタゴニスト
Education (3)：
- 2000 - 2002 東京大学大学院 薬学系研究科 分子薬学専攻
- 1998 - 2000 The University of Tokyo Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences
- 1996 - 1998 The University of Tokyo College of Arts and Sciences
Professional career (1)：
Work history (9)：
- 2019/06 - 現在 Tokyo Medical and Dental University Institute of Biomaterials and Bioengineering
- 2018/04 - 2019/05 The University of Tokyo
- 2013/12 - 2018/03 The University of Tokyo Institute of Molecular and Cellular Biosciences
- 2012/04 - 2013/11 Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University Assistant professor
- 2009/04 - 2012/03 Tokyo Medical and Dental University Assistant professor
- 2007/08 - 2009/03 Tokyo Medical and Dental University Assistant professor
- 2004/04 - 2007/07 Tokushima Bunri University Assistant professor
- 2002/04 - 2004/03 Kyowa Hakko Kogyo Co.Ltd. Researcher
- Tokyo Medical and Dental University Institute of Molecular and Cellular Biosciences Laboratory of Bioorganic Chemistry Others
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Awards (6)：
Association Membership(s) (5)：
THE CHEMICAL SOCIETY OF JAPAN
, Japanese society for retinoid research
, THE VITAMIN SOCIETY OF JAPAN
, JAPANESE SOCIETY FOR CHEMICAL BIOLOGY
, 日本薬学会
