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J-GLOBAL ID：200901074860053138 Update date: Jan. 31, 2024

Minamisawa Susumu

ミナミサワススム | Minamisawa Susumu

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://sminamis.m38.coreserver.jp/Jikei_Cell_Physiology/Welcome.html

Research field (5)： Fetal medicine/Pediatrics , Cardiology , Clinical pharmacy , Physiology , Developmental biology

Research keywords (3)：心臓・血管・発達・医学 , Developmental Biology and Physiology , Cardiovascular Medicine

Research theme for competitive and other funds (33)：

2023 - 2026 Development of a method to inhibit muscle atrophy by targeting direct sarcoplasmic reticulum Ca2+ reuptake mechanism activation by drugs.
2022 - 2025 酸素による内皮細胞を介した解剖学的動脈管閉鎖機構の探索
2021 - 2024 動脈管閉鎖の分子機構解明
2020 - 2023 筋小胞体へのCa2+再取り込み促進を標的とした筋萎縮抑制法の開発
2019 - 2023 酸素による血管リモデリングを標的とした動脈管閉鎖機構の解明

2017 - 2021 Characterization of specificity and pathophysiology in pulmonary veins

2016 - 2019 Troponin T replacement can be a new therapy for dilated cardiomyopathy

2016 - 2019 Microstructual analysis of human ductal tissue using synchrotron-based x-ray phase-contrast tomography and immunohistochemical analyses

2016 - 2018 Elucidation of oxygen-sensing molecular mechanisms on fetal pulmonary artery and ductus arteriosus

2015 - 2018 Biomarkers of cardiac fibrosis in pressure overloaded heart.

2014 - 2017 Molecular mechanisms of ductus arteriosus closure

2014 - 2015 Search for a promoting factor of internal elastic lamina formation derived from endothelial cells

2011 - 2014 Molecular mechanisms of ductus arteriosus closure

2011 - 2013 拍動循環培養システムを用いた心チューブの構築と機能解析

2011 - 2012 The efficacy of the low frequency electrical acupuncture to the disuse muscle atrophy

2010 - 2012 Investigation of the mechanism of ductus arteriosus closure affected by changes in serum osmolality

2010 - 2012 心不全治療にむけた心筋筋小胞体制御機構の解明

2010 - 2011 Mechanical stimulation-induced vascular elastogenesis

2008 - 2010 Molecular mechanisms of closure of the ductus arteriosus

2007 - 2008 Promoting vascular differentiation could be a new therapeutic strategy for patent ductus arteriosus in premature infant s

2007 - 2008 Molecular mechanism of autonomic regulation of cardiac function

2006 - 2007 The effect of aging and pressure overload on the heart of SERCA2a mutant mice

2006 - 2007 GTP結合蛋白によるcAMPシグナルの制御メカニズム

2005 - 2006 Molecular mechanisms for cardiac regulation by the autonomic nervous system

2005 - 2005 細胞内酵素機能障害としてのパーキンソン病の研究

2004 - 2004 がん細胞の増殖とカベオリン

2003 - 2004 The molecular mechanisms for sympathetic regulation of cardiac function

2003 - 2004 Generation of sarcolipin heart-specific transgenic mice and molecular mechanism of atrial chamber-specific expression

2003 - 2003 がん細胞の増殖とカベオリン

2001 - 2002 The elucidation of disease gene and deletion mechanism in del 22q11.2 syndrome.

2001 - 2002 Is the enhancement of the sarcoplasmic reticulum function susceptible to arrhythmias?

心血管系における細胞内カルシウム制御機構の解明、発達心血管病学

Developmental Cardiovascular Research, Calcium Homeostasis in the Cardiovascular system

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Papers (248)：

Norika Liu, Naofumi Kawahira, Yasuhiro Nakashima, Haruko Nakano, Akiyasu Iwase, Yasunobu Uchijima, Mei Wang, Sean M. Wu, Susumu Minamisawa, Hiroki Kurihara, et al. Notch and retinoic acid signals regulate macrophage formation from endocardium downstream of Nkx2-5. Nature Communications. 2023. 14. 1
Norika Liu, Naofumi Kawahira, Yasuhiro Nakashima, Haruko Nakano, Akiyasu Iwase, Yasunobu Uchijima, Mei Wang, Sean M. Wu, Susumu Minamisawa, Hiroki Kurihara, et al. Notch and retinoic acid signals regulate macrophage formation from endocardium downstream of Nkx2-5. Nature Communications. 2023. 14. 1
Jun Tanihata, Susumu Minamisawa. Urinary titin is not an early biomarker of skeletal muscle atrophy induced by muscle denervation in mice. PloS one. 2023. 18. 8. e0289185
前谷浩史, 山口裕也, 谷端淳, 馬場俊輔, 森本幸生, 南沢享. 野生型トロポニンT過剰発現は,トロポニンT変異型拡張型心筋症を改善する. 東京慈恵会医科大学雑誌. 2022. 137. 6. 125-126
大嶋理香, 宮本汐里, 黒松俊吾, 谷端淳, 暮地本宙己, 南沢享, 寺田昌弘. 宇宙航空科学技術推進委託費事業による有人宇宙医学実習の取り組み. 宇宙航空環境医学. 2022. 59. 1. 23-23

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MISC (246)：

馬場, 俊輔, 赤池, 徹, 暮地本, 宙生, 新庄, 聡子, 南沢, 享, 大石, 公彦, ババ, シュンスケ, アカイケ, トオル, ボチモト, ヒロアキ, シンジョウ, サトコ, et al. 心房特異的Pitx2c過剰発現はカルシウム調節異常により上室不整脈を増加させる (第138回成医会総会一般演題)-Atrial cardiomyocyte-specific Pitx2c overexpression increases atrial arrhythmias through altered calcium regulation. 東京慈恵会医科大学雑誌. 2021. 136. 6. 141-142
竹尾真, 草刈洋一郎, 暮地本宙己, MOHD ZIN Nur Khatijah, 南沢享. Transient myocardial hyperextension via protein kinase A activation increases the relaxation rate of rat cardiac muscle. 東京慈恵会医科大学雑誌. 2021. 136. 6
BABA Shunsuke, AKAIKE Toru, SHINJO Satoko, BOCHIMOTO Hiroki, MINAMISAWA Susumu. Atrium-specific Pitx2c Overexpression Impaired Sinus Node Function and Increased Atrial Arrythmias. Journal of Physiological Sciences (Web). 2021. 71. Supplement 1
SEYA Daiki, AKAIKE Toru, MINAMISAWA Susumu. Transcriptional profiles of the rat pulmonary vein during a perinatal period. Journal of Physiological Sciences (Web). 2021. 71. Supplement 1
YOKOTA Takako, AKAIKE Toru, MINAMISAWA Susumu. The transcription factor Nr4a1 may contribute to anatomical closure of the ductus arteriosus via regulating hyaluronic acid production. Journal of Physiological Sciences (Web). 2021. 71. Supplement 1

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Patents (1)：

ヒアルロン酸合成促進による内膜肥厚及びその利用

Books (19)：

症例問題から学ぶ生理学原書4版
丸善出版 2018
ガイトン生理学原著第13版
エルゼビア・ジャパン株式会社 2018
カラー図解よくわかる生理学の基礎第2版
メディカルサイエンスインターナショナル 2017
Physiologic and Pathologic Angiogenesis - Signaling Mechanisms and Targeted Therapy
InTech - Open Access Publisher 2017
Muscle Contraction and Cell Motility: Fundamentals and Developments
Pan Stanford 2016

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Education (1)：

- 1984 Hirosaki University School of Medicine

Professional career (1)：

MD, PhD

Work history (32)：

2016/04 - 現在 Jikei University
2012/05 - 現在 Jikei University
2013/04 - 2020/03 早稲田大学先進理工学研究科・客員教授(非常勤)
2007/04 - 2015/03 Yokohama City University Graduate School of Medicine, Graduate
2004/01 - 2012/04 Waseda University Faculty of Science and Engineering

2005/07 - 2007/03 Waseda University Consolidated Research Institute for Advanced Science and Medical Care

2004/01 - 2007/03 横浜市立大学大学院医学研究科循環制御医科学・生理学第1講座・助教授

2005/04 - 2006/03 Nagoya University Research Institute of Environmental Medicine

2002/01 - 2003/12 横浜市立大学生理学第1講座・講師

2000/06 - 2001/12 東京女子医大心臓血圧研究所循環器小児科・特任助手

1996/01 - 2000/05 University of California San Diego, Department of Medicine, postdoctoral researcher

1993/04 - 1995/12 Tsurumi University School of Dental Medicine

1991/07 - 1993/03 東京女子医大心臓血圧研究所循環器小児科・練士

1991/04 - 1991/06 横浜市立大学・助手(小児科)

1989/04 - 1991/03 横浜市立大学・医務吏員(小児科)

1986/12 - 1989/03 藤沢市民病院・医師(小児科)

1986/06 - 1986/12 Yokohama City University

1984/06 - 1986/06 横浜市立大学・臨床研修医

4/1/07-present Visiting Professor, Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama

4/1/07-present Professor, department of Life Science and Medical Bio-Science Advanced Science and Engineering, Waseda University, Tokyo

7/1/05-3/31/07 Visiting Professor, Consolidated Research Institute for Advanced Science and Medical Care, Waseda University, Tokyo

University Graduate School of Medicine, Yokohama

1/1/02-3/31/07 Associate Professor, Cardiovascular Research Institute, Yokohama City

6/1/00- 12/31/01 Assistant Professor, Department of Pediatric Cardiology, Tokyo Women's Medical University, The Heart Institute of Japan, Tokyo

1/1/96- 5/31/00 Postdoctoral Researcher, Department of Medicine, University of California, San Diego

4/1/93 - 12/31/95 Assistant Professor, Department of Physiology, Tsurumi University, Yokohama

6/2/91 - 3/31/93 Clinical Fellow in Pediatric Cardiology, Tokyo Women's Medical University, The Heart Institute of Japan, Tokyo

4/1/91 - 6/1/91 Assistant Professor, Department of Pediatrics, Yokohama City University, Yokohama

4/1/89 - 3/31/91 House Staff in Pediatrics, Yokohama City University Hospital, Yokohama

12/2/86 - 3/31/89 House Staff in Pediatrics, Fujisawa Citizen Hospital

6/2/86 - 12/1/86 House Staff in Pediatrics, Yokohama City University Hospital, Yokohama

6/2/84 - 6/1/86 Clinical Fellow, Yokohama City University Hospital, Yokohama

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Committee career (16)：

2018/04 - 現在日本生理学会教育委員会委員長
2018 - 現在日本宇宙航環境空医学会理事
2017/12 - 現在文部科学省科研費委員会専門委員
2017 - 現在日本宇宙航空環境医学会評議員
2016 - 現在日本生理学会入澤記念若手賞選考委員会

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Awards (4)：

2014 - Takao Award
2011 - Japan Pediatric Society Research Award of Japan Pediatric Society
2010/08 - 横浜総合医学振興財団梅原賞
2003/04 - 横浜市立大学医学会賞

Association Membership(s) (19)：

JAPAN SOCIETY OF AEROSPACE AND ENVIRONMENTAL MEDICINE , 日本心不全学会 , 日本心臓病学会 , 日本小児科学会 , 日本循環器学会 , 日本小児循環器学会 , 日本生理学会 , アメリカ心臓協会 , アメリカ生理学会 , The japanese heart Failure Society , The Japanese College of Cardiology , Japan pediatric Society , The japanese Circulation Society , japanese Society of Pediatric Cardiology and Cardiac Surgery , japan Society of Circulation Control in Medicine , Physiological Society of Japan , American Heart Association , American Society for Biochemistry and Molecular Biology , The American Physiological Society

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