Rchr
J-GLOBAL ID：200901080410886466
Update date: Mar. 10, 2024
Kobayashi Takuya
コバヤシ タクヤ | Kobayashi Takuya
Affiliation and department：
Research field (1)：
Biophysics
Research keywords (7)：
骨格筋
, リアノジン受容体
, 微小管
, ダイナクチン
, ダイニン
, イメージング
, 生物物理学
Research theme for competitive and other funds (5)：
- 2022 - 2025 Elucidation of molecular mechanism for depolarization-induced Ca2+ release using novel reconstitution system
- 2021 - 2024 Structural analysis of the gating mechanism of cardiac ryanodine receptor
- 2020 - 2023 筋構造ー収縮力相関における微小管の役割
- 2019 - 2022 新規リアノジン受容体作用薬を利用したサブタイプ特異的チャネル制御の分子機構
- 2016 - 2019 A study of a mechano-network system based on microtubules by a constructive approach
Papers (20)：
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Kyohei Matsuda, Wonyeong Jung, Yusei Sato, Takuya Kobayashi, Masahiko Yamagishi, Taeyoon Kim, Junichiro Yajima. Myosin-induced F-actin fragmentation facilitates contraction of actin networks. Cytoskeleton. 2024
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Takashi Murayama, Nagomi Kurebayashi, Takuro Numaga-Tomita, Takuya Kobayashi, Satoru Okazaki, Kyosuke Yamashiro, Tsutomu Nakada, Shuichi Mori, Ryosuke Ishida, Hiroyuki Kagechika, et al. A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery. The Journal of general physiology. 2022. 154. 12
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Nagomi Kurebayashi, Takashi Murayama, Ryosaku Ota, Junji Suzuki, Kazunori Kanemaru, Takuya Kobayashi, Seiko Ohno, Minoru Horie, Masamitsu Iino, Fumiyoshi Yamashita, et al. Cytosolic Ca2+-dependent Ca2+ release activity primarily determines the ER Ca2+ level in cells expressing the CPVT-linked mutant RYR2. The Journal of general physiology. 2022. 154. 9
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Takuya Kobayashi, Akihisa Tsutsumi, Nagomi Kurebayashi, Kei Saito, Masami Kodama, Takashi Sakurai, Masahide Kikkawa, Takashi Murayama, Haruo Ogawa. Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations. Nature communications. 2022. 13. 1. 2821-2821
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Toshiko Yamazawa, Takuya Kobayashi, Nagomi Kurebayashi, Takashi Murayama. [Therapeutic effects of novel type1 ryanodine receptor inhibitor on skeletal muscle diseases]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 2022. 157. 1. 15-22
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MISC (19)：
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Hirofumi Shimizu, Takuya Kobayashi, Masayuki Iwamoto, Kentaro Kajiwara, Nagomi Kurebayashi, Haruo Ogawa, Takashi Murayama. Single-Molecule Twisting Motions During Gating of the Human TRPV1 Channel Recorded with Sub-Millisecond Time Resolution. BIOPHYSICAL JOURNAL. 2020. 118. 3. 22A-22A
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Takashi Murayama, Toshiko Yamazawa, Takuya Kobayashi, Nagomi Kurebayashi, Satoru Noguchi, Ichizo Nishino, Shuichi Mori, Hiroyuki Kagechika, Jose R. Lopez, Paul D. Allen. Therapeutic Effects of a Novel RyR1 Inhibitor on Malignant Hyperthermia-Susceptible Model Mice. BIOPHYSICAL JOURNAL. 2020. 118. 3. 98A-98A
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村山 尚, 山澤 徳志子, 小林 琢也, 呉林 なごみ, 野口 悟, 井上 高良, 井上 由紀子, 森 修一, 飯沼 大翔, 間中 紀暁, et al. 悪性高熱症モデルマウスを用いた新規1型リアノジン受容体阻害薬の治療効果の検討. 日本筋学会学術集会プログラム・抄録集. 2019. 5回. 185-185
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Kei Saito, Takashi Murayama, Tomonori Hata, Takuya Kobayashi, Yoko Y. Toyoshima. New Folding Pattern of P150 and "Anntena'' for Dynein Binding. BIOPHYSICAL JOURNAL. 2014. 106. 2. 353A-354A
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Yuta Watanabe, Toshiyuki Kitai, Takuya Kobayashi, Takashi Murayama, Takayuki Takahagi, Yoko Y. Toyoshima. Structural Analysis of Cytoplasmic Dynein Tail Domain. BIOPHYSICAL JOURNAL. 2011. 100. 3. 457-457
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Education (3)：
- 2002 - 2005 東京大学大学院 総合文化研究科 博士課程
- 2000 - 2002 北里大学大学院 基礎生命科学研究科 修士課程
- 1996 - 2000 北里大学 理学部 生物科学科
Professional career (1)：
Work history (6)：
Association Membership(s) (1)：
THE BIOPHYSICAL SOCIETY OF JAPAN
