Murakawa Takeshi

ムラカワタケシ | Murakawa Takeshi

Affiliation and department：
Job title： Others

Research field (1)： Structural biochemistry

Research keywords (2)：酵素 , X線結晶構造解析

Research theme for competitive and other funds (18)：

2023 - 2027 Real-time structural dynamics analysis in protein crystal under controlled environmental conditions (temperature and pH).
2023 - 2026 速度論および熱力学的手法を用いた"in crystallo" 酵素反応解析
2022 - 2024 シリアルフェムト秒結晶構造解析に基づく銅含有アミン酸化酵素の触媒機構の解明
2020 - 2023 非凍結結晶を用いた“in crystallo”酵素反応解析
2020 - 2022 シリアルフェムト秒結晶構造解析による銅含有アミン酸化酵素の触媒機構の解明

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Papers (39)：

Takeshi Murakawa, Kazuo Kurihara, Mitsuo Shoji, Naomine Yano, Katsuhiro Kusaka, Yoshiaki Kawano, Mamoru Suzuki, Yasuteru Shigeta, Takato Yano, Motoyasu Adachi, et al. Neutron Crystallography of a Semiquinone Radical Intermediate of Copper Amine Oxidase Reveals a Substrate-Assisted Conformational Change of the Peptidyl Quinone Cofactor. ACS Catalysis. 2023. 12403-12413
Kenji Fukui, Tatsuya Yamamoto, Takeshi Murakawa, Seiki Baba, Takashi Kumasaka, Takato Yano. Catalytic mechanism of the zinc-dependent MutL endonuclease reaction. Life Science Alliance. 2023. 6. 10. e202302001-e202302001
Seiki BABA, Takeshi MURAKAWA. X-ray Crystallographic Analysis of Copper Amine Oxidase in Physiological Environments using Humid Air and Glue-coating(HAG)Method. Nihon Kessho Gakkaishi. 2022. 64. 4. 285-289
Yasuo Watanabe, Youichi Suzuki, Akino Emi, Takeshi Murakawa, Takayuki Hishiki, Fumihiro Kato, Shoichi Sakaguchi, Hong Wu, Takato Yano, Chang-Kweng Lim, et al. Identification of the corticotropin-releasing factor receptor 1 antagonists as inhibitors of Chikungunya virus replication using a Gaussia luciferase-expressing subgenomic replicon. Biochemical and Biophysical Research Communications. 2022. 637. 181-188
Takeshi Murakawa, Mamoru Suzuki, Kenji Fukui, Tetsuya Masuda, Michihiro Sugahara, Kensuke Tono, Tomoyuki Tanaka, So Iwata, Eriko Nango, Takato Yano, et al. Serial femtosecond X-ray crystallography of an anaerobically formed catalytic intermediate of copper amine oxidase. Acta Crystallographica Section D Structural Biology. 2022. 78. Pt 12. 1428-1438

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MISC (16)：

中原駿哉, 中谷茉矢, 福井健二, 村川武志, 矢野貴人, 増井良治. 高度好熱菌Thermus thermophilus HB8の脂肪酸キナーゼ触媒サブユニットFakAのATP結合ドメインの結晶構造解析. 日本生化学会大会プログラム・講演要旨集. 2021. 94回. [1T15m-208)]
井上葵, 高尾和也, 福井健二, 村川武志, 矢野貴人, 増井良治. RHH型DNA結合タンパク質がもつC末端ヘリックスのリン酸化制御への関与. 日本生化学会大会プログラム・講演要旨集. 2021. 94回. [P-227]
村川武志, 岡島俊英. 宙に浮く水素イオン?!-大型タンパク質の中性子結晶構造解析で見えた特異な世界-(4月28日、プレス発表). J-PARC News. 2020. 181. 2-2
村川武志, 馬場清喜, 河野能顕, 林秀行, 矢野貴人, 熊坂崇, 山本雅貴, 谷澤克行, 岡島俊英. 銅含有アミン酸化酵素触媒機構の“in crystallo“熱力学的解析. 日本細胞生物学会大会(Web). 2019. 71st
岡島俊英, 村川武志, 栗原和男, 安達基泰, 柴崎千枝, 玉田太郎, 林秀行, 谷澤克行. Active-site structure of copper amine oxidase determined by high-resolution X-ray and neutron crystallography. 量子ビームサイエンスフェスタ(Web). 2017. 2016

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Professional career (1)：

博士(理学) (大阪大学)

Work history (1)：

2006/04 - 現在大阪医科大学

Association Membership(s) (4)：

THE VITAMIN SOCIETY OF JAPAN , THE CHEMICAL SOCIETY OF JAPAN , THE JAPANESE BIOCHEMICAL SOCIETY , PROTEIN SCIENCE SOCIETY OF JAPAN

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