Rchr
J-GLOBAL ID:200901080671475544
Update date: Mar. 26, 2024
Shibayama Naoya
シバヤマ ナオヤ | Shibayama Naoya
Affiliation and department:
Job title:
Professor
Homepage URL (1):
http://www.jichi.ac.jp/divbio/index.html
Research field (2):
Biophysics
, Structural biochemistry
Research keywords (8):
ヘモグロビン
, Hemoglobin
, アロステリー
, Allostery
, X-ray crystallography
, ゾル・ゲル法
, Sol-gel
, Protein folding
Research theme for competitive and other funds (17):
- 2020 - 2023 Determination of single hemoglobin dynamics with x-rays
- 2019 - 2023 ヘモグロビン結晶構造の半網羅的機能決定
- 2016 - 2019 働く最中のヘモグロビン分子内動態の原子レベル追跡
- 2014 - 2019 バイオロジーにおける3D活性サイト科学
- 2015 - 2017 ヘモグロビンの四次構造変化を許容する結晶を用いた時分割構造解析法の開拓
- 2011 - 2013 Elucidation of the true picture of the hemoglobin allosteric equilibrium
- 2008 - 2009 タイマータンパク質EA4の計時機構解明を目指した研究
- 2005 - 2007 Slow motion analysis of the fokling reactions of proteins within wet silica gels
- 2000 - 2002 ゾル・ゲル包括法によるタンパク質分子の構造・機能解析
- 1998 - 1999 多孔性ゲルによるタンパク質の微視的構造状態の機能解析
- 1996 - 1996 多孔性ガラスによるタンパク質の高次構造固定法を用いたタンパク質機能の研究
- 1994 - 1994 多孔性ガラスによるタンパク質の高次構造固定法の開発と2状態モデルの直接的検証
- 1993 - 1993 架橋混成ヘモグロビンを用いたアロステリック効果の研究
- 1992 - 1992 急速凍結X線吸の収スペクトル法による錯体、金属タンパク質の反応過程の解析
- 1991 - 1991 X線吸収スペクトルの時間分解測定による錯体,金属タンパク質の反応過程の解析
- 1990 - 1990 分散型EXAFS法の高感度化とそれによる錯体,金属酵素の反応の動的解析
- 1989 - 1989 金属置換混成ヘモグロビンを用いたヘモグロビンの酸素結合中間状態に関する研究
Show all
Papers (69):
-
Artoni Kevin R Ang, Yasufumi Umena, Ayana Sato-Tomita, Naoya Shibayama, Naohisa Happo, Riho Marumi, Yuta Yamamoto, Koji Kimura, Naomi Kawamura, Yu Takano, et al. Development of serial X-ray fluorescence holography for radiation-sensitive protein crystals. Journal of synchrotron radiation. 2023. 30. Pt 2. 368-378
-
Nagatomo, S, Shoji, M, Terada, T, Nakatani, K, Shigeta, Y, Hirota, S, Yanagisawa, S, Kubo, M, Kitagawa, T, Nagai, M, et al. Heme-bound tyrosine vibrations in hemoglobin M: resonance Raman, crystallography and DFT calculation. Biophys. J. 2022. 121. 14. 2767-2780
-
Naoki Yamamoto, Jiro Kikuchi, Yusuke Furukawa, Naoya Shibayama. Fast in-vitro screening of FLT3-ITD inhibitors using silkworm-baculovirus protein expression system. PLOS ONE. 2022. 17. 5. e0261699-e0261699
-
Naoki Yamamoto, Maiko Kofu, Kenji Nakajima, Hiroshi Nakagawa, Naoya Shibayama. Freezable and Unfreezable Hydration Water: Distinct Contributions to Protein Dynamics Revealed by Neutron Scattering. The Journal of Physical Chemistry Letters. 2021. 12. xxxx. 2172-2176
-
Naoya Shibayama, Ayana Sato-Tomita, Mio Ohki, Kouhei Ichiyanagi, Sam-Yong Park. Direct observation of ligand migration within human hemoglobin at work. Proceedings of the National Academy of Sciences. 2020. 117. 9. 4741-4748
more...
MISC (31):
-
Artoni Kevin R. Ang, Ayana Sato-Tomita, Naoya Shibayama, Yasufumi Umena, Naohisa Happo, Riho Marumi, Koji Kimura, Tomohiro Matsushita, Kazuto Akagi, Takahiko Sasaki, et al. X-ray fluorescence holography for soft matter. Japanese Journal of Applied Physics. 2020. 59. 1
-
Toshiyuki Chatake, Andrii Y. Kovalevsky, Naoya Shibayama, SamYong Park, Takuya Ishikawa, Marat Mustyakimov, Paul Langan, Yukio Morimoto. Time of Flight Neutron Crystallographic Analysis of Human Deoxyhemoglobin. IUCr2008 Satellite symposium. 2008
-
SY Park, N Shibayama, T Hiraki, JRH Tame. Crystal structures of unliganded and half-liganded human hemoglobin derivatives cross-linked between Lys 82 beta(1) and Lys 82 beta(2). BIOCHEMISTRY. 2004. 43. 27. 8711-8717
-
S Saigo, N Shibayama. Highly nonexponential kinetics in the early-phase refolding of proteins at low temperatures. BIOCHEMISTRY. 2003. 42. 32. 9669-9676
-
S Adachi, SY Park, JRH Tame, Y Shiro, N Shibayama. Direct observation of photolysis-induced tertiary structural changes in hemoglobin. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2003. 100. 12. 7039-7044
more...
Lectures and oral presentations (43):
-
Slow Ligand Migration Dynamics in Tetramerio Hemoglobin at Cryogenic Temperature
(物構研サイエンスフェスタ要旨集 2013)
-
セルフタイマーを内蔵するタンパク質EA4
(日本蛋白質科学会年会プログラム・要旨集 2012)
-
3SA4-05 The true nature of the allosteric equilibrium of hemoglobin(3SA4 Hemoglobin revisited,The 47th Annual Meeting of the Biophysical Society of Japan)
(Biophysics 2009)
-
Vibrio parahaemolyticus由来機能未知c<sub>4</sub>-type cytochromeの大腸菌での大量発現,精製と物理化学的性質の決定
(日本農芸化学会大会講演要旨集 2009)
-
パルス中性子源を用いたヒト由来デオキシヘモグロビンの中性子実験
(京都大学原子炉実験所学術講演会報文集 2008)
more...
Education (4):
- - 1985 Osaka University
- - 1985 Osaka University Graduate School, Division of Engineering Science
- - 1983 Osaka University School of Engineering Science Direct Affiliates
- - 1983 Osaka University Faculty of Engineering Science
Professional career (1):
Work history (1):
- Jichi Medical University Lecturer
Committee career (1):
- 2010/01 - 現在 日本生物物理学会 分野別専門委員(アロステリズム)
Association Membership(s) (3):
American Society of Biochemistry and Molecular Biology
, 日本生化学会
, 日本生物物理学会
Return to Previous Page