Rchr
J-GLOBAL ID：200901080887666255   Update date: Apr. 04, 2024

Hakata Yoshiyuki

ハカタ ヨシユキ | Hakata Yoshiyuki
Affiliation and department：
Kindai University Faculty of Medicine Department of Medicine

About Kindai University Faculty of Medicine Department of Medicine


Job title： Associate Professor
Homepage URL  (1)： http://www.med.kindai.ac.jp/immuno/
Research field  (3)： Virology ,  Biochemistry ,  Molecular biology
Research keywords  (16)： オートファジー ,  アポトーシス誘導ペプチドの開発 ,  機能性ペプチドの細胞内送達法の開発 ,  機能性ペプチドの開発 ,  レトロウイルスのGag-Pol前駆体タンパク質切断 ,  viral protein and cellular cofactor interaction ,  autophagy-inducible peptides ,  HIVとSIVのVpr/Vpxタンパク質 ,  AID/APOBEC family ,  retrotransposon ,  retrovirus ,  murine leukemia virus ,  nucleocytoplasmic shuttling ,  viral RNA nuclear export ,  human immunodeficiency virus ,  human T-cell leukemia virus-1
Research theme for competitive and other funds  (18)：
  • 2023 - 2026 抗ウイルス遺伝子産物により誘導される細胞内ウイルスRNA分解の新機構
  • 2022 - 2025 Mechanisms of B-lymphomagenesis in the absence of APOBEC3 cytidine deaminase
  • 2019 - 2022 Identification of host genes that regulate neutralizing antibody production upon retrovirus infections and their mechanisms of action
  • 2016 - 2019 Effective functional improvement of proteins and peptides delivered into cell by peptide zipper method
  • 2016 - 2019 Molecular mechanism of APOBEC3-mediated inhibition on Gag-Pol autoprocessing
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Papers (24)：
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MISC (1)：
  • Shunichi Shiozawa, Ken Tsumiyama, Yumi Miyazaki, Kenichi Uto, Keiichi Sakurai, Toshie Nakashima, Hiroko Matsuyama, Ai Doi, Miho Tarui, Manabu Izumikawa, et al. DOCK8-expressing Tfh cells cause SLE: autoimmunity via repeated TCR stimulation by antigen to levels that surpass system's self-organized criticality. JOURNAL OF IMMUNOLOGY. 2021. 206
Books (1)：
  • The Frontier of peptide Drug Discovery
    2019
Lectures and oral presentations  (38)：
  • Intracellular delivery of functional peptides using heterodimeric leucine zippers containing unnatural amino acids
    (日本化学会春季年会講演予稿集(Web) 2022)
  • Conjugation of a functional peptide with a cell-penetrating peptide via “peptide nucleic acid fastener“ and evaluation of the intracellular activity
    (日本化学会春季年会講演予稿集(Web) 2021)
  • Evaluation of autophagy induction by fragment peptides derived from Vpr protein of immunodeficiency virus
    (日本化学会春季年会講演予稿集(Web) 2021)
  • Synthesis and evaluation of a conjugate of apoptosis-inducing peptide with cell penetrating peptide containing photodegradable linker
    (日本化学会春季年会講演予稿集(Web) 2021)
  • Conjugation of a functional peptide with a cell-penetrating peptide via “peptide fastener“ and evaluation of the intracellular activity
    (日本化学会春季年会講演予稿集(Web) 2021)
ｍore...
Education (4)：
  • - 2002 Kyoto University
  • - 2002 Kyoto University Graduate School, Division of Natural Science Chemistry (Subcellular Biogenesis)
  • - 1996 Doshisha University
  • - 1996 Doshisha University Faculty of Engineering Department of Applied Chemistry
Professional career (2)：
  • Doctor (Science) (Kyoto University)
  • Master (Science) (Kyoto University)
Work history (6)：
  • 2014/04 - 現在 Kindai University Faculty of Medicine・Department of Immunology Lecturer
  • 2008/06 - 2014/03 Kindai University Faculty of Medicine・Department of Immunology Assistant Professor
  • 2006/11 - 2008/05 New York University School of Medicine・Department of Microbiology Postdoctoral Fellow
  • 2005/03 - 2006/10 The Salk institute for biological studies Infectious Disease Laboratory Postdoctoral Fellow
  • 2002/09 - 2005/06 Hokkaido University Institute for genetic medicine Assistant Professor
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Association Membership(s) (1)：
日本ウイルス学会
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