Rchr
J-GLOBAL ID：200901081920783595
Update date: Apr. 01, 2024
Yoneda Toshiyuki
ヨネダ トシユキ | Yoneda Toshiyuki
Affiliation and department：
Research field (3)：
Oral medicine
, Metabolism and endocrinology
, Molecular biology
Research keywords (6)：
骨破壊
, 情報伝達
, 骨代謝
, Bone Destruction
, Signalling
, Bone Metabolism
Research theme for competitive and other funds (37)：
- 2023 - 2027 骨細胞保護によるがんの骨転移新規治療戦略の開発
- 2021 - 2025 口腔癌骨破壊病変における知覚神経と癌細胞の相互作用メカニズムの解明
- 2020 - 2024 乳酸シャトルによる骨転移進展の制御
- 2017 - 2020 Role of sensory nerve in cancer progession
- 2015 - 2017 Development of a novel mouse model that recapitulates bone invasion of oral cancer
- 2014 - 2017 Biological crosstalk between cancer and bone during bone metastasis
- 2014 - 2016 Development of a novel mouse model that recapitulates bone metastasis seen in human.
- 2011 - 2014 Molecular mechanim of cancer-associated bone pain caused by protons
- 2011 - 2012 Identification of genes involved in biological crosstalk between cancer and bone
- 2010 - 2011 Investigation for development of technique reprogramming of mesenchymal stem cells using epigenetic analyses
- 2008 - 2010 Integrative Study of transcriptional network systems during enchondral ossification
- 2007 - 2009 Transcruptional Regulation of Sox9 during endochondral ossification
- 2007 - 2009 Understanding of molecular basis by which Indian hedgehog signaling regulates osteoblast differentiation
- 2005 - 2009 Cross talk between bone microenvironment and metastatic cancer cell
- 2006 - 2008 Molecular mechanisms of the metastasis of malignant bone tumors and anti-metastasis therapy
- 2006 - 2008 前立腺がんの造骨性骨転移の分子病態の解析
- 2005 - 2007 Investigation of molecular mechanisms of Sox9 transcriptional factory during enchandral ossification
- 2005 - 2006 Regulation of cancer-induced bone pain by inhibition of acid sensing receptor
- 2003 - 2006 Investigation of relationship between Osterix and Cbfal during BMP2-induced osteoblast differentiation
- 2000 - 2004 c-Srcリン酸化を介する転写因子NF-κBの活性化と骨吸収の制御
- 2001 - 2002 破骨細胞の骨吸収エネルギー産生におけるナトリウム依存性リン輸送体の役割
- 2000 - 2002 The Regulation of osteobiastogenesis and adipogenesis by BMP2
- 1999 - 2001 Cloning of the molecules associated with bone metastases of cancers and its characterization
- 1999 - 2001 The Regulation of Bone-Remodeling by Signals mediated by Phosphorylation
- 1999 - 2000 REGULATION OF OSTEOCLASTIC BONE RESORPTION BY RHO
- 1998 - 1999 未分化間葉系細胞の骨芽細胞、及び脂肪細胞への分化の分子細胞生物学的解析
- 1998 - 1999 Role of Cytokines Signaling in Osteoblastic Differentiation
- 1986 - 1986 口腔領域悪性腫瘍患者における高カルシウム血症の発症機序に関する研究
- 1985 - 1986 Mechanism on the rise and fall of NK activity and CTL in tumor bearing mice in comparison with cryosurgery.
- アジュバント性骨転移治療薬の開発
- 骨痛のメカニズム
- 骨代謝とシグナリング
- 癌の骨転移に関する研究
- Development of adjuvantic therapeutic agents for bone metastasis
- Mechanism of bone pain
- Signalling in Bone Metabolism
- Mechanisms of Cancer Metastasis to Bone
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Papers (95)：
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Tatsuo Okui, Masahiro Hiasa, Kenji Hata, G David Roodman, Masako Nakanishi, Toshiyuki Yoneda. The acid-sensing nociceptor TRPV1 controls breast cancer progression in bone via regulating HGF secretion from sensory neurons. Research square. 2023
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Toshiyuki Yoneda, Masahiro Hiasa, Tatsuo Okui, Kenji Hata. Cancer-nerve interplay in cancer progression and cancer-induced bone pain. Journal of bone and mineral metabolism. 2023. 41. 3. 415-427
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Tatsuo Okui, Masahiro Hiasa, Kazuaki Hasegawa, Tomoya Nakamura, Kisho Ono, Soichiro Ibaragi, Takahiro Kanno, Akira Sasaki, Toshiyuki Yoneda. Lactate secreted via MCT4 from bone-colonizing breast cancer excites sensory neurons via GPR81. International journal of oncology. 2023. 62. 3
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Shota Ishihara, Kenji Hata, Katsutoshi Hirose, Tatsuo Okui, Satoru Toyosawa, Narikazu Uzawa, Riko Nishimura, Toshiyuki Yoneda. The lactate sensor GPR81 regulates glycolysis and tumor growth of breast cancer. Scientific Reports. 2022. 12. 1
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Koichiro Ono, Kenji Hata, Eriko Nakamura, Shota Ishihara, Sachi Kobayashi, Masako Nakanishi, Michiko Yoshida, Yoshifumi Takahata, Tomohiko Murakami, Seiichi Takenoshita, et al. Dmrt2 promotes transition of endochondral bone formation by linking Sox9 and Runx2. Communications Biology. 2021. 4. 1
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MISC (103)：
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波多賢二, 高畑佳史, 村上智彦, 西村理行, 米田俊之. 乳酸受容体GPR81は骨における乳がん細胞の増殖を制御する. 日本骨代謝学会学術集会プログラム抄録集(CD-ROM). 2022. 40th
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小野孝一郎, 波多賢二, 中村恵理子, 高畑佳史, 村上智彦, 西村理行, 米田俊之. 転写因子Dmrt2は内軟骨性骨化におけるSox9からRunx2への分子間ネットワークを制御する. 日本軟骨代謝学会プログラム・抄録集. 2018. 31st
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日浅雅博, 日浅雅博, 奥井達雄, 奥井達雄, 米田俊之, 米田俊之. V-ATPaseプロトンポンプおよび酸感受性イオンチャンネルASIC3阻害は多発性骨髄腫の骨痛を緩和する. 日本骨代謝学会学術集会プログラム抄録集. 2017. 35th. 205-205
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波多 賢二, 吉田 倫子, 西村 理行, 米田 俊之. 骨・軟骨分化の制御機構 内軟骨性骨化を制御する転写因子の同定とその分子メカニズムの解明. 日本整形外科学会雑誌. 2016. 90. 8. S1423-S1423
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日浅雅博, 奥井達雄, 永田友貴, 米田俊之, 米田俊之. 骨細胞は痛覚神経を刺激して骨痛を増悪する. 日本骨代謝学会学術集会プログラム抄録集. 2015. 33rd. 166-166
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Patents (3)：
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Dental products comprising bone growth-enhancing peptide.
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Integrin binding motif-containing peptides & methods of treating skeletal diseases
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Methods to ameliorate osteolysis and metastasis
Books (1)：
Works (3)：
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骨形成促進薬剤の開発
2001 -
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転移に対するMMP阻害剤の効果
1999 -
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Effects of MMP inhibitors on bone metastasis
1999 -
Education (4)：
- - 1976 Osaka University
- - 1976 Osaka University Graduate School, Division of Dental Research
- - 1972 Osaka University School of Dentistry School of Dentistry
- - 1972 Osaka University Faculty of Dentistry
Professional career (1)：
- (BLANK) (Osaka University)
Work history (10)：
- 1997 - 2000 Osaka University School of Dentistry
- 1997 - 2000 Osaka Univ. Faculty Dent, Dept. Biochemistry, Professor
- 2000 - - 大阪大学大学院歯学研究科 教授
- 2000 - - Osaka University Graduate School of Dentistry, Professor
- 1995 - 1997 テキサス大学サンアントニオ校医学部内分泌代謝部門 教授
- 1995 - 1997 Univ. TXat San Antonio, Div. Endocrinology, Professor
- 1990 - 1995 テキサス大学サンアントニオ校医学部内分泌代謝部門 助教授
- 1990 - 1995 Univ. TXat San Antonio, Div. Endocrinology, Associate Professor
- 1992 - 1993 Tokyo Medical and Dental University Medical Research Institute
- 1992 - 1993 Tokyo Med. Dent. Univ. Med Res Inst., Professor
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Committee career (1)：
Awards (1)：
Association Membership(s) (4)：
歯科基礎医学会
, 日本骨代謝学会
, 日本癌学会
, 日本生化学会
