Rchr
J-GLOBAL ID：200901082351947203
Update date: Mar. 23, 2024
Niisato Naomi
ニイサト ナオミ | Niisato Naomi
Affiliation and department：
Homepage URL (1)：
http://www.f.kpu-m.ac.jp/k/physiol/
Research field (3)：
Clinical pharmacy
, Physiology
, Cell biology
Research keywords (2)：
分子生理学
, Molecular Physiology
Research theme for competitive and other funds (20)：
- 2015 - 2018 A targeting mechanism of membrane protein to proteasome
- 2013 - 2016 Molecular mechanisms of cancer metastasis induced by disrupting the WNK kinase mediated cytosolic Cl- homeostasis
- 2013 - 2015 Continuous pH measurement of interstitial fluid and clarification of pathogenic mechanism of insulin resistance by ISFET pH sensor
- 2012 - 2015 Inhibitory mechanism of quercetin on ENaC in salt-sensitive hypertension
- 2011 - 2013 Recovery mechanism from LPS-induced lung edema by HGF
- 2012 - 2012 クロライドイオンによる低分子量Gタンパク質の活性制御を介した神経細胞死の抑制
- 2008 - 2011 Regulation of intracellular localization of ENaC by protease
- 2008 - 2010 TLR gene expression in e ndotoxin-induced lung injury
- 2007 - 2008 Cell survival and apoptosis through Cl_-dependent regulation of Akt and JNK in renal epithelium
- 2006 - 2008 Molecular regulation of ENaC in the process of recovery in permeability lung edema
- 2005 - 2007 Investigation of aldosterone action on ENaC in salt-sensitive hypertension
- 2006 - 2006 癌細胞増殖におけるクロライドイオン要求性の分子メカニズム
- 2005 - 2006 Molecular mechanism of osmosensing and ENaC gene expression by src kinase.
- 2003 - 2004 脳浮腫発症に果たすアルドース還元酵素の役割解明と酵素阻害剤による治療の試み
- 2003 - 2004 Regulatory mechanism of Na+ reabsorption by hypotonicity through regulatory volume decrease-dependent dephosphorylation of FAK.
- 2001 - 2002 Regulatory mechanism of CI^- transport via tyrosine phophorylation by cAMP
- ENaC遺伝子発現と腎ナトリウム再吸収制御機構に関する研究
- 細胞内クロライドイオンによるチロシンリン酸化制御機構に関する研究
- Study on the relationship between protein tyrosine kinase activation and cell volume regulation
- Study on regulatory mechanisms of epithelial ion transport
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Papers (77)：
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Shigekuni Hosogi, Atsukazu KUWAHARA, Yuko KUWAHARA, Saori TANAKA, Chikao SHIMAMOTO, Noriko TAGAWA, Ikuo KATO, Kanji YOSHIMOTO, Wataru AOI, Kazuyuki TAKATA, et al. Mumefural prevents insulin resistance and amyloid-beta accumulation in the brain by improving lowered interstitial fluid pH in type 2 diabetes mellitus. Biomedical Research. 2023. 44. 1. 17-29
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NIISATO N, Marunaka Y. Amiloride-sensitive distal nephron controls extracellular fluid volume: ENaC and aldosterone. Kidney and Dialysis. 2022. 93. 5. 690-694
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Yoshinori Marunaka, Naomi Niisato, Xiaobo Zou, Jian Bo Xiao, Takashi Nakahari. Food intake targeting and improving acidity in diabetes and cancer. Food Frontiers. 2020. 1. 1. 9-12
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Ma Z, Taruno A(co-first author, Ohmoto M, Jyotaki M, Lim JC, Miyazaki H, Niisato N, Marunaka Y, Lee RJ, Hoff H, et al. CALHM3 is essential for rapid ion channel-mediated purinergic neurotransmission of GPCR-mediated tastes. Neuron. 2018
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Sasamoto K, Marunaka R, Niisato N, Sun H, Taruno A, Pezzotti G, Yamamoto T, Kanamura N, Zhu W, Nishio K, et al. Analysis of Aprotinin, a Protease Inhibitor, Action on the Trafficking of Epithelial Na+ Channels (ENaC) in Renal Epithelial Cells Using a Mathematical Model. Cellular Physiology and Biochemistry. 2017. 41. 5. 1865-1880
ｍore...
MISC (132)：
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Yoshinori Marunaka, Naomi Niisato, Hongxin Sun, Toshio Inui. INSULIN AND THE CFTR CHLORIDE CHANNEL. PEDIATRIC PULMONOLOGY. 2016. 51. 177-177
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Yoshinori Marunaka, Kouhei Sasamoto, Naomi Niisato, Akiyuki Taruno. Simulation of Cl- secretion in epithelial tissues. FASEB JOURNAL. 2016. 30
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笹本 浩平, 新里 直美, 丸中 良典. 上皮組織クロライドイオン分泌に寄与する電気的中性クロライドイオン輸送体活性の電気生理学的測定の新展開 : 数学的シミュレーション活用による新測定法の確立 (第13回肺サーファクタント分子病態研究会). 分子呼吸器病. 2015. 19. 1. 130-134
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Maki Kitagawa, Naomi Niisato, Shigekuni Hosogi, Atsushi Shiozaki, Eigo Otsuji, Yoshinori Marunaka. A role of K+-Cl- cotransporter in the cell cycle regulation of breast cancer MDA-MB-231 cells. JOURNAL OF PHYSIOLOGICAL SCIENCES. 2013. 63. S137-S137
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Hiroaki Miyazaki, Naomi Niisato, Yoshinori Marunaka. Oscillatory changes in the activity of Na+/K+/2Cl(-) co-transporter control cell cycle progression via changes in the intracellular concentration of Cl- in MKN28 human gastric cancer cells. JOURNAL OF PHYSIOLOGICAL SCIENCES. 2013. 63. S200-S200
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Books (4)：
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Ion Transport: Calcium Channels. In: Janes SM. (Ed.), Encyclopedia of Respiratory Medicine
Elsevier, Academic Press 2022
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Osmotransduction through volume-sensitive Cl- channels. In: Kamkin A & Kiseleva I (Eds.), Mechanosensitive Ion Channels.
Springer 2007 ISBN:9781402064258
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Ion Transport: Calcium Channels. In: Janes, S.M. (Ed.), Encyclopedia of Respiratory Medicine
Elsevier, Academic Press 2006
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Catecholamine regulation of amiloride-sensitive Na+transport in the fetal rat alveolar epithelium. In Current Topic in Membrane.
Academic Press 1999 ISBN:0121533476
Lectures and oral presentations (3)：
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MKP-1-dependent ERK dephosphorylation stimulates Na+ reabsorption through beta- and gamma-ENaC expression in hypotonic stress
(<p> 36th International Congress of Physiological Sciences (IUPS)</p> 2009)
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ERK dephosphorylation by MKP-1 stimulates Na+ reabsorption through beta- and gamma-ENaC expression in hypotonic stress
(<p>Satellite Symposium of International Union of Physiological Sciences (IUPS)-2009 "Epithelial Ion Transport in Health and Disease" </p> 2009)
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Dephosphorylation of ERK by MKP-1 stimulates beta- and gamma-ENaC mRNA expression of renal A6 cells in hypotonic stress
(<p> 40th NIPS International Symposium</p> <p>International Joint Symposium 2009 " Physiology of Anion Transporter" and " Cell Volume Regulation"</p> <p> </p> 2009)
Professional career (1)：
- Ph. D. (Tokyo Institute of Technology)
Committee career (1)：
Association Membership(s) (4)：
日本腎臓学会
, 日本生化学会
, 日本生理学会
, 分子生物学会
