Kishioka Shiroh

• 2012 - 2012 Identification of crosstalk between pathological angiogenesis and neurons in regulating chronic pain
• 2010 - 2012 Study on pathophysiological mechanism underlying leptin-induced exacerbation of neuropathic pain
• 2009 - 2011 Study on neuropathic pain associated with pre-diabetes and obese
• 2008 - 2010 Involvement of opioid system in nicotine and alcohol dependence
• 2007 - 2008 神経因性疼痛増悪因子としてのアディポサイトカインに関する研究
2006 - 2008 Detection and identification of lipid-derived radicals formed by myoglobin released from damaged skeletal muscles after excessive exercise
2006 - 2007 Ligands for peroxisome proliferaoractivated receptor as possible novel analgesic
2005 - 2007 Comparative study of nicotin and morphine dependence
2006 - Studies of mechanisms of neuropathic pain and its treatment
Research on Mechanism of the development of tolerance to and dependance on opioid analgesics

• Kiguchi N, Ding H, Peters CM, Kock ND, Kishioka S, Cline JM, Wagner JD, Ko MC. Altered expression of glial markers, chemokines, and opioid receptors in the spinal cord of type 2 diabetic monkeys. Biochimica et biophysica acta. 2017. 1863. 1. 274-283
• Norikazu Kiguchi, Haruka Sakaguchi, Yui Kadowaki, Fumihiro Saika, Yohji Fukazawa, Shinsuke Matsuzaki, Shiroh Kishioka. Peripheral administration of interleukin-13 reverses inflammatory macrophage and tactile allodynia in mice with partial sciatic nerve ligation. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2017. 133. 1. 53-56
• Norikazu Kiguchi, Devki D. Sukhtankar, Huiping Ding, Ken-ichi Tanaka, Shiroh Kishioka, Christopher M. Peters, Mei-Chuan Ko. Spinal Functions of B-Type Natriuretic Peptide, Gastrin-Releasing Peptide, and Their Cognate Receptors for Regulating Itch in Mice. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2016. 356. 3. 596-603
• Fumihiro Saika, Norikazu Kiguchi, Shiroh Kishioka. [The role of CC-chemokine ligand 2 in the development of psychic dependence on methamphetamine]. Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence. 2015. 50. 5. 189-95
• Norikazu Kiguchi, Fumihiro Saika, Yuka Kobayashi, Mei-Chuan Ko, Shiroh Kishioka. TC-2559, an alpha 4 beta 2 nicotinic acetylcholine receptor agonist, suppresses the expression of CCL3 and IL-1 beta through STAT3 inhibition in cultured murine macrophages. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2015. 128. 2. 83-86

ｍore...

• Norikazu Kiguchi, Takehiko Maeda, Yuka Kobayashi, Yohji Fukazawa, Shiroh Kishioka. Activation of Extracellular Signal-Regulated Kinase in Sciatic Nerve Contributes to Neuropathic Pain After Partial Sciatic Nerve Ligation in Mice. ANESTHESIA AND ANALGESIA. 2009. 109. 4. 1305-1311
• Takehiko Maeda, Norikazu Kiguchi, Yuka Kobayashi, Toshihiko Ikuta, Masanobu Ozaki, Shiroh Kishioka. Leptin derived from adipocytes in injured peripheral nerves facilitates development of neuropathic pain via macrophage stimulation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009. 106. 31. 13076-13081
• Norikazu Kiguchi, Takehiko Maeda, Yuka Kobayashi, Yohji Fukazawa, Shiroh Kishioka. Leptin enhances CC-chemokine ligand expression in cultured murine macrophage. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2009. 384. 3. 311-315
• Luqing Shang, Hao Fang, Huawei Zhu, Xuejian Wang, Qiang Wang, Jiajia Mu, Binghe Wang, Shiroh Kishioka, Wenfang Xu. Design, synthesis and SAR studies of tripeptide analogs with the scaffold 3-phenylpropane-1,2-diamine as aminopeptidase N/CD13 inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY. 2009. 17. 7. 2775-2784
• Saika F, Kiguchi N, Kobayashi Y, Fukazawa Y, Maeda T, Ozaki M, Kishioka S. Suppressive effect of imipramine on vincristine-induced mechanical allodynia in mice. Biol Pharm Bull. 2009. 32. 7. 1231-1234

ｍore...

• オピオイドの研究の進歩と展望
  ネオメディカル 2004
• ペインクリニシャンのためのオピオイドの基礎と臨床
  真興貿易 2004
• 痛み臨床における鎮痛薬・オピオイドの選択(分担執筆)
  ミクス 2003
• オピオイド治療 課題と新潮流(分担執筆)
  ミクス 2001
• オピオイドの基礎と臨床(分担執筆)
  ミクス 2000

ｍore...

• - 1979 Wakayama Medical University Faculty of Medicine
• - 1979 Wakayama Medical University Faculty of Medicine

• Ph D (Wakayama Medical University)

• 1995 - 1997 Wakayama Medical University
• 1995 - 1997 Wakayama Medical University, Associate Professor
• 1997 - - 和歌山県立医科大学 教授
• 1997 - - Wakayama Medical University, Professor
• 1991 - 1995 Wakayama Medical University
1991 - 1995 Wakayama Medical University, Assistant Professor
1988 - 1991 Wakayama Medical University
1988 - 1991 Wakayama Medical University, Research Assistant
1979 - 1987 Wakayama Medical University
1979 - 1987 Wakayama Medical University, Research Assistant

• 1985 - 和歌山医学会 古武賞

日本依存神経精神科学会 ,  THE JAPANESE SOCIETY FOR THE STUDY OF PAIN ,  JAPAN SOCIETY FOR MEDICAL EDUCATION ,  Society of Neuroscience ,  American Society for Pharmacology and Experimental Therapeutics ,  College on Problems of Drug Dependence ,  日本眼薬理学会 ,  日本臨床薬理学会 ,  日本神経科学学会 ,  日本神経精神薬理学会 ,  日本薬理学会 ,  College on Problems of Drug Dependence