2021 - 2025 Tailer made-dual directed immunotherapy for pancreatic cancer
2021 - 2024 IL-17とがん幹細胞ニッチをターゲットにした新規分子標的療法の開発
2021 - 2024 網羅的ctDNA変異解析モニタリングによる膵癌個別化集学的治療の開発
2021 - 2024 革新的腫瘍細胞ワクチンを核とした複合免疫療法の開発
2021 - 2024 Development of new synchronized chemotherapy by controlling exercise therapy stress and drug transporter expression vibration
2021 - 2024 Development of novel precision immunotherapy based on the tumor immuno-environment
2021 - 2024 Analysis of molecular mechanisum of pancreatic cancer cell death and immune responce after carbon ion radiiation and its application to surgery
2020 - 2023 Physical and mental function of patients undergoing preoperative chemotherapy for pancreatic cancer and effect of preoperative rehabilitation
2020 - 2023 癌関連線維芽細胞をターゲットとした大腸癌微小環境制御を目指した基礎的研究
2020 - 2023 The novel strategy of ubiquitin-fusion cancer vaccine through the specific delivery to XCR1+ Dendritic cells
2020 - 2023 Development of tailor-made iPS-DC cancer vaccine therapy targeting Neoantigen
2018 - 2022 Elucidation of molecular biological effect of prehabilitation for pancreaticoduodenectomy
2018 - 2021 Development of new pancreatic cancer therapy combined with anti-tumor effect of exercise stress
2018 - 2021 Personalized medicine by monitoring ctDNA for pancreatic cancer
2018 - 2021 Multi-omics analysis for hepato-biliary-pancreatic cancers
2017 - 2021 Exploratory research of driver gene mutation and drug sensitivity-related genes expression changes in hepatocellular carcinoma
2017 - 2021 Cancer vaccine therapy using peptide pulsed iPS derived DCs for pancreas cancer patients
2017 - 2020 The development of a novel whole cell tumor vaccine with selective delivery ability to XCR1+ dendritic cells
2017 - 2020 A basic research of Cancer vaccine therapy using genetically modified iPSDCs expressing WT1 gene
2017 - 2020 Optimal adjustment of clinical application for oncolytic virotherapy against esophageal cancer
2017 - 2020 Cancer vaccine therapy using iPS-DCs expressing TAA and TGF-beta R
2017 - 2020 Development of novel immunotherapy for colon cancer targeting CEACAM1
2017 - 2020 Development of the new cancer immunotherapy using iPS-DC which inhibited immune checkpoint
2016 - 2019 Novel pancreatic cancer treatment combining immune suppression mechanism and autophagy induction virus therapy
2016 - 2019 A novel peptide vaccine therapy using in vivo antigen delivery to XCR1+DCs
2015 - 2019 Immunotherapy using dendritic cell targeting cancer stem cell
2015 - 2018 Low invasive treatment using pancreatic cancer vaccine
2015 - 2018 Development of new cancer immunotherapy focused on the subset of dendritic cell
2015 - 2018 Liquid biopsy sequencing for liver cancer and pancreatic tumor
2014 - 2017 Pathogenesis of cytokine storm in necrotizing enterocolitis develop a treatment strategy
2014 - 2017 Elucidation of the development of necrotizing enterocolitis: an approach using microchimerism visualized rats.
2014 - 2017 Model to predict the risk of intra-abdominal abscess after pancreaticoduodenectomy by analysis of cytokine in bile
2014 - 2017 Relationship between pancreatic cancer and adiponectin
2014 - 2017 The development of molecular target drug through the control of IL23/Th17 pathway in tumor microenvironment.
2014 - 2017 Establishment of therapeutic models using oncolytic viruses for gastric cancer
2014 - 2017 Cancer vaccine therapy using iPS-derived dendritic cells expressing TAA
2014 - 2017 Serum exosomal CEACAM1 as a novel tumor marker for colorectal cancer
2014 - 2017 Development of the new cancer immunotherapy using iPS- derived CTLs for cancer stem cells
2014 - 2017 Development of innovative peptide vaccine therapy using iPS cell-derived dendritic cells against pancreatic cancer patients
2013 - 2016 Immunotherapy for pancreatic cancer using iPS cell-derived dendritic cell and autophagy-inducing oncolytic virus
2013 - 2016 New diagnostic strategy during laparoscopic surgery for patients with colorectal cancer
2012 - 2015 Treatment strategy of pancreatic cancer based on genome-wide profile
2012 - 2015 Development of cancer vaccine therapy by targeting cell cycle of cancer stem cell
2011 - 2014 The new strategy applied with bidirectional peptide vaccine therapy for pancreatic cancer.
2011 - 2013 Model for early detection of clinically relevant pancreatic fistula after pancreaticoduodenectomy by analysis of cytokine in drainage fluid
2011 - 2013 New development of a selective oncolytic virotherapy for gastric cancer
2011 - 2013 Composition of fatty acids in phospholipids and functions of neutrophils in patients with malnutrition induced by liver dysfunction after surgery
2011 - 2013 Novel therapeutic starategy for CEACAM1 expressing colorectal cancer cells beyond the invasion front
2011 - 2013 Development of the new cancer immunotherapy using fusion cell-vaccine of iPSDC and cancer stem cell
2011 - 2012 Research and development of an armed oncolytic virus via autophagyfor gastroenterological cancer
2010 - 2012 Diagnosis of malignant pancreatic tumor by the expression of MPF
2010 - 2012 Development of novel therapy targeting IL-17 in tumor microenvironment
2010 - 2012 Preoperative chemo-radiation therapy for rectal cancer by analysis of chemo-radiation sensitizing gene expression
2009 - 2011 Real time measurement of Hydroxylradical following ischemia-reperfusion injury model using rabbit liver.
2009 - 2011 Development of cancer stem cell vaccine therapy based on the Niche theory
2009 - 2010 遺伝子発現プロファイリングを応用した膵癌に対する新規ペプチド免疫療法の開発
2008 - 2010 Development of the new radiation therapy using tumor suppressor gene NPRL2 for esophageal cancer
2008 - 2010 Novel exploitation of hybrid-type armed oncolytic virus for scirrhous gastric cancer
2008 - 2010 Novel differentiation induction therapy for colorectal cancer by targeting to CEACAM1
2008 - 2010 Nutritional effects of the novel fat emulsion emulsified by phosphatidylglycerol after cirrhotic liver resection
2008 - 2010 Development of cancer vaccine therapy using dendritic cells transduced with TGF-βsiRNA for digestive cancer
2007 - 2009 Novel therapeutic target for regulation of inflammation in tumor microenvironment
2007 - 2009 Development of newly immuno-viral therapy incorporated in tumor microenvironment theory for gastrointestinal cancer
2007 - 2008 A study of the molecular biology using Oncostatin M aimed for liver reproduction after the cirrhotic liver resection
2007 - 2008 Exhaustive gene analysis on mechanism of resistance for anti-cancer agents under hypoxic condition
2006 - 2007 Malignat diagnosis of intraductal papillary-mucinous neoplasms by transcriptome analysis of pure pancreatic juice
2006 - 2007 Development of new cancer immunotherapy using activation of Toll like receptor against gastrointestinal cancer
2005 - 2007 Development of molecular therapy targeted for tumor cell and tumor stoma of peritoneal dissemination
2005 - 2007 An experimental study on cancer vaccine therapy using dendritic cells genetically transduced with the tumor antigen gene and the ubiquitin gene
2004 - 2007 In vitro chemosensitivity test to predict chemosensicivity for paclitaxel, using human gastric carcinoma tissues.
2004 - 2006 Investigation for pancreatic cancer associated with hypoxia-inducible factor
2004 - 2006 Basic immunological analyses of vaccine using dendritic cells transfected tumor RNA against digestive cancer
2004 - 2005 Combination gene therapy of HGF and truncated type II TGF-β receptor for rat liver cirrhosis after partial hepatectomy
2003 - 2005 Cancer vaccine therapy using genetically modified dendritic cells expressing tumor-associated antigen and cytokines
2001 - 2003 Prediction of distant metastasis by using reverse transcriptase-polymerase chain reaction for epithelial and variant CD44 mRNA in the blod of the patients with colorectal cancer
2000 - 2002 Development of cancer vaccine therapy targeting CEA and the analysis of its immunologicai responses
2000 - 2002 Experimental study on the vaccine therapy targeting p53 as a tumor antigen
2000 - 2002 An experimental study on antitumor immuno-gene therapy using dendritic cells genetically modified to express the tumor antigen gene and cytokine gene
1999 - 2001 Development of new tumor specific gene therapy in gastrointestinal carcinoma
1997 - 1999 Development for CMV vaccine using the cytotoxic peptide after transplantation
1997 - 1998 遺伝子組み換え抗腫瘍抗体の新らしいヒト型抗体作製法の開発
1995 - 1997 Estasblishment of adoptive immunotherapy for cancer using T lymphocytes engneered by interleukin-2 gene
1991 - 1993 Analysis of the mechanism of defective autologous mixed lymphocyte reaction in cancer patients
1987 - 1989 OK432により誘導される活性化NK細胞の養子免疫療法の確立
膵癌の集学的治療
Multidisciplinary treatment for pancreatic cancer
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Papers (610)：
Hirotaka Kato, Shinya Hayami, Masaki Ueno, Norihiko Suzaki, Masashi Nakamura, Tomohiro Yoshimura, Atsushi Miyamoto, Yoshinobu Shigekawa, Ken-Ichi Okada, Motoki Miyazawa, et al. Histone methyltransferase SUV420H1/KMT5B contributes to poor prognosis in hepatocellular carcinoma. Cancer Science. 2023
Ken-Ichi Okada, Kenjiro Kimura, Yo-Ichi Yamashita, Kazuto Shibuya, Ippei Matsumoto, Sohei Satoi, Kazuhiro Yoshida, Yasuhiro Kodera, Takahiro Akahori, Seiko Hirono, et al. Efficacy and safety of neoadjuvant nab-paclitaxel plus gemcitabine therapy in patients with borderline resectable pancreatic cancer: A multicenter single-arm phase II study (NAC-GA trial). Annals of gastroenterological surgery. 2023. 7. 6. 997-1008
Taichi Terai, Manabu Kawai, Yuji Kitahata, Sohei Satoi, Daisuke Hashimoto, Minako Nagai, Satoshi Nishiwada, Tomohisa Yamamoto, Hiroki Yamaue, Masayuki Sho. Central pancreatectomy might be an acceptable surgical procedure for clinical T1 pancreatic body ductal adenocarcinoma: A multicenter retrospective analysis. Journal of hepato-biliary-pancreatic sciences. 2023
Kota Nakamura, Minako Nagai, Ippei Matsumoto, Sohei Satoi, Fuyuhiko Motoi, Manabu Kawai, Yasuo Hosouchi, Ryota Higuchi, Shugo Mizuno, Takao Ohtsuka, et al. Impact of antithrombotic therapy on postpancreatectomy hemorrhage in 7116 patients: A project study by the Japanese Society of Hepato-Biliary-Pancreatic Surgery. Journal of hepato-biliary-pancreatic sciences. 2023
1975 - 1981 Wakayama Medical University Faculty of Medicine
Professional career (1)：
Doctor(Medicine) (Wakayama Medical University)
Work history (5)：
2022/04 - 現在 Wakayama Medical University Department of Cancer Immunotherapy Professor
2001/06 - 2022/03 Wakayama Medical University Second Department of Surgery Professor
1999/06 - 2001/05 和歌山県立医科大学附属病院 集学的治療・緩和ケア部 助教授
1991/08 - 1999/05 Wakayama Medical University Second Department of Surgery Lecturer
1985/11 - 1991/07 Wakayama Medical University Second Department of Surgery Instructor
Committee career (11)：
日本メディカルAI学会 顧問
日本がん免疫学会 理事
日本バイオセラピィ学会 理事・評議員
日本腹部救急医学会 評議員
日本癌学会 評議員
日本胃癌学会 代議員
日本肝胆膵外科学会 理事・評議員
日本癌治療学会 評議員
日本臨床外科学会 評議員
日本消化器外科学会 理事・評議員
日本外科学会 代議員
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Awards (5)：
2017 - 一般社団法人日本外科学会 2017(平成29)年度日本外科学会臨床研究助成
2017 - The 10th pancreatic cancer international conference in Taiwan The Pin-Wen Lin Award 2017
2011 - 公益法人小林がん学術振興会 平成23年度第5回革新的研究助成
2010 - 財団法人藤井節郎記念 大阪基礎医学研究奨励会 平成22年度研究助成金
1995 - 第1回国際胃癌学会 優秀演題賞
Association Membership(s) (14)：
日本バイオセラピィ学会
, 日本腹部救急医学会
, 日本癌学会
, 日本胃癌学会
, 日本肝胆膵外科学会
, 日本癌治療学会
, 日本臨床外科学会
, 日本消化器外科学会
, 日本外科学会
, The Japanese Association of Hepato-Biliary-Pancreatic Surgery
, Japan Society of Clinical Oncology
, Japan Surgical Association
, The Japan Society of Gastroenterological Surgery
, Japan Surgical Society
