Rchr
J-GLOBAL ID：200901083337927654
Update date: Jan. 30, 2024
Uemura Masako
ウエムラ マサコ | Uemura Masako
Affiliation and department：
Research field (1)：
Pharmaceuticals - analytical and physicochemistry
Research keywords (3)：
がん
, 白金錯体
, 生物無機化学
Research theme for competitive and other funds (5)：
- 2019 - 2023 制がん白金二核錯体の輸送機構の解明とオキサリプラチン耐性大腸がんに対する活性評価
- 2019 - 2022 Development of a next-generation platinum-based drug with a markedly high and long-lasting antitumor efficacy
- 2017 - 2019 Screening for cancer stem cell-targeted dinuclear platinum(II) complex
- 2015 - 2018 Drug discovery research based on dinuclear platinum complexes with markedly high antitumor activity
- 2012 - 2015 Development of next-generation anticancer drugs using dinuclear transition metal complexes
Papers (12)：
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Masako Uemura, Keiichi Hiramoto, Hiroki Yoneyama, Shinya Harusawa, Seiji Komeda. Introduction of Fluorine into Antitumor-Active Dinuclear Platinum(II) Complexes Leads to Modulation of In Vivo Antitumor Activity in Mice. Inorganic chemistry. 2022. 61. 31. 12155-12164
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Seiji Komeda, Hiroki Yoneyama, Masako Uemura, Takahiro Tsuchiya, Miyuu Hoshiyama, Tomoya Sakazaki, Keiichi Hiramoto, Shinya Harusawa. Data on synthesis and structure-activity relationships of tetrazolato-bridged dinuclear platinum(II) complexes. Data in brief. 2022. 40. 107697-107697
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Seiji Komeda, Hiroki Yoneyama, Masako Uemura, Takahiro Tsuchiya, Miyuu Hoshiyama, Tomoya Sakazaki, Keiichi Hiramoto, Shinya Harusawa. Synthesis and structure-activity relationships of tetrazolato-bridged dinuclear platinum(II) complexes: A small modification at tetrazole C5 markedly influences the in vivo antitumor efficacy. Journal of inorganic biochemistry. 2019. 192. 82-86
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Masako Uemura, Seiji Komeda. Kinetic analysis of and platinum(II) migration in the reactions of tetrazolato-bridged dinuclear platinum(II) complexes with nucleotides. Journal of inorganic biochemistry. 2017. 177. 359-367
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Seiji Komeda, Hiroki Yoneyama, Masako Uemura, Akira Muramatsu, Naoto Okamoto, Hiroaki Konishi, Hiroyuki Takahashi, Akimitsu Takagi, Wakao Fukuda, Tadayuki Imanaka, et al. Specific Conformational Change in Giant DNA Caused by Anticancer Tetrazolato-Bridged Dinuclear Platinum(II) Complexes: Middle-Length Alkyl Substituents Exhibit Minimum Effect. Inorganic chemistry. 2017. 56. 2. 802-811
ｍore...
Professional career (2)：
- 修士(薬学) (広島大学)
- 博士(薬科学) (大阪薬科大学)
Association Membership(s) (2)：
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