Rchr
J-GLOBAL ID：200901084029782986
Update date: Jan. 31, 2024
Fukunaga Rikiro
フクナガ リキロウ | Fukunaga Rikiro
Affiliation and department：
Job title：
教授
Homepage URL (1)：
http://www.oups.ac.jp/english/index.html
Research field (3)：
Cell biology
, Molecular biology
, Functional biochemistry
Research keywords (5)：
細胞死
, 細胞分化
, 細胞増殖
, 細胞内情報伝達
, Intracellular signal transduction
Research theme for competitive and other funds (23)：
- 2019 - 2022 Crosstalk between the Mnk- and mTOR-signaling pathways in tumor-related translational regulation
- 2018 - 2021 Identification of downstream factors of the ERK-MAP kinase pathway as a putative target for treatment of signal transduction disorders.
- 2015 - 2018 Molecular mechanism of translational regulation mediated by the crosstalk between mTOR and Mnk signaling pathways in tumorigenesis
- 2012 - 2015 Molecular Mechanisms for cell growth regulation by Mnk-mediated translational control
- 2011 - 2013 造血細胞の増殖・分化を制御するクロマチン構造変換の分子機構の解明
- 2011 - 2013 Targeting Mnk/eIF4E pathway for cancer therapy
- 2005 - 2006 The role of MNK1/2 in cardiovascular remodeling
- 2000 - 2004 MOLECULAR MECHANISM OF CELL DEATH AND ITS PHYSIOLOGICAL ROLE
- 2000 - 2001 Molecular mechanism of growth and differentiation of neutrophilic granulocyte mediated by G-CSF
- 1998 - 2001 造血細胞のシグナル伝達
- 1998 - 1999 Molecular mechanism of growth and differentiation of neutrophilic granulocyte mediated by G-CSF
- 1994 - 1999 アポト-シスの分子機構とその生理作用
- 1995 - 1996 G-CSF-induced proliferation and differentiation of neutrophils
- 1992 - 1993 顆粒球コロニー刺激因子受容体の解析
- 1991 - 1991 がんの増殖と分化に関連する遺伝子の発現制御
- 1990 - 1991 Studies on granulocyte colony-stimulating factor receptor
- 1987 - 1988 Mechanism of Antiviral Action of Interferon: Analysis Using 2-5A Synthetase Producing Cells
- 1987 - 1988 Proliferation and differentiation of granulocytes
- 1987 - 1987 インターフェロンにより誘導される2-5A合成酵素の遺伝子発現調節
- 造血細胞の増殖・分化の分子機構
- プロテインキナ-ゼを介した細胞内情報伝達機構の研究
- Molecular Mechanism for Hematopoiesis
- Mechanism of Intracellular Signal Transduction Mediated by Protein Kinases
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Papers (38)：
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Toshihiro Fujii, Naomi Inoue, Takanobu Nobeyama, Junko Inoue, Shin Ogasawara, Yuhei Otani, Shinobu Fujii, Chihiro Ito, Rikiro Fukunaga. A simple, rapid, and efficient method for generating multigene-knockout culture cells by the CRISPR/Cas9 system. Genes to Cells. 2023
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Purev Erdenebaatar, I Ketut Gunarta, Ryusuke Suzuki, Ravdandorj Odongoo, Toshihiro Fujii, Rikiro Fukunaga, Masato T Kanemaki, Katsuji Yoshioka. Redundant roles of extra-cellular signal-regulated kinase (ERK) 1 and 2 in the G1-S transition and etoposide-induced G2/M checkpoint in HCT116 cells. Drug Discoveries & Therapeutics. 2023
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Liu, Dong, Li, Jin, Lin, Hao, Lorsung, Ethan, Le, Nam, Singla, Rubal, Mishra, Abhishek, Fukunaga, Rikiro, Cao, Ruifeng. Circadian activities of the brain MNK-eIF4E signalling axis contribute to diurnal rhythms of some cognitive functions. European Journal of Neuroscience. 2022. 56. 1. 3553-3569
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Manne, Bhanu Kanth, Campbell, Robert A., Bhatlekar, Seema, Ajanel, Abigail, Denorme, Frederik, Portier, Irina, Middleton, Elizabeth A., Tolley, Neal D., Kosaka, Yasuhiro, Montenont, Emilie, et al. MAPK-interacting kinase 1 regulates platelet production, activation, and thrombosis. Blood. 2022. 140. 23. 2477-2489
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Elsesser O, Fröb F, Küspert M, Tamm ER, Fujii T, Fukunaga R, Wegner M. Chromatin remodeler Ep400 ensures oligodendrocyte survival and is required for myelination in the vertebrate central nervous system. Nucleic acids research. 2019. 47. 12. 6208-6224
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MISC (53)：
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Y. Shi, P. Frost, B. Hoang, Y. Yang, R. Fukunaga, J. Gera, A. Lichtenstein. MNK kinases facilitate c-myc IRES activity in rapamycin-treated multiple myeloma cells. Oncogene. 2013. 32. 2. 190-197
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C. Courilleau, L. Mattera, G. Legube, T. Ueda, R. Fukunaga, M. Chevillard-Briet, Y. Canitrot, F. Escaffit, D. Trouche. ATPase p400 module the cellular future through regulation of ROS homeostasis. BULLETIN DU CANCER. 2010. 97. S39-S39
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S Iida, T Kohro, T Kodama, S Nagata, R Fukunaga. Identification of CCR2, flotillin, and gp49B genes as new G-CSF targets during neutrophilic differentiation. JOURNAL OF LEUKOCYTE BIOLOGY. 2005. 78. 2. 481-490
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R Watanabe-Fukunaga, S Iida, Y Shimizu, S Nagata, R Fukunaga. SEI family of nuclear factors regulates p53-dependent transcriptional activation. GENES TO CELLS. 2005. 10. 8. 851-860
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S Iida, T Kohro, T Kodama, S Nagata, R Fukunaga. Identification of CCR2, flotillin, and gp49B genes as new G-CSF targets during neutrophilic differentiation. JOURNAL OF LEUKOCYTE BIOLOGY. 2005. 78. 2. 481-490
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Books (1)：
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"Identifying protein kinase substrates by expression screening with solid-phase phosphorylation". in: Protein Phosphorylation: A Practical Approach, 2nd Ed., (Hardie, D.G., Ed.)
Oxford University Press, Oxford. 1999
Education (4)：
- - 1986 Kyoto University
- - 1986 Kyoto University Graduate School, Division of Natural Science
- - 1981 Kyoto University Faculty of Science
- - 1981 Kyoto University Faculty of Science
Professional career (1)：
- Rigaku-Hakushi (Doctor of Science)
Work history (8)：
- 2021/04 - 現在 Osaka Medical and Pharmaceutical University Faculty of Pharmacy Professor
- 2010/11 - 現在 Osaka University of Pharmaceutical Sciences Department of Biochemistry Professor
- 2007/04 - 2010/10 Kyoto University Graduate School of Medicine Associate Professor
- 2001/04 - 2007/03 :大阪大学生命機能研究科助教授
- 1996/04 - 2001/03 :大阪大学医学部助教授
- 1993/03 - 1996/03 :米国ソーク生物学研究所研究員
- 1988/03 - 1993/02 :(財)大阪バイオサイエンス研究員
- 1986/06 - 1988/02 :京都大学助手(ウイルス研究所)
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Awards (1)：
Association Membership(s) (3)：
日本薬学会
, 日本分子生物学会
, 日本生化学会
