Ishimaru Naozumi

イシマルナオズミ | Ishimaru Naozumi

Affiliation and department：
Other affiliations (2)：

The University of Tokushima
Tokushima University Hospital Department of Pathology

Homepage URL (1)： https://ishimarun.wixsite.com/oralpathol

Research field (3)： Immunology , Surgical dentistry , Oral medicine

Research keywords (9)：診断病理学 , 免疫制御 , 腫瘍免疫 , アレルギー , 自己免疫疾患 , 免疫学 , 病理学 , Immunology , Pathology

Research theme for competitive and other funds (31)：

2023 - 2027 Novel pathogenesis and therapeutic strategy of autoimmunity based on immune-tuning molecules
2021 - 2024 Common molecular mechanisms underlying age- and autoimmune-related disturbance of salivary secretion
2019 - 2024 臓器間コミュニケーションを介した自己免疫疾患発症機序の解明
2021 - 2023 唾液腺ムチンタンパクの糖鎖形成異常を介した自己免疫疾患の新たな発症機序の解明
2019 - 2022 Establishment of novel oral cancer stem cell model mimicking human oral cancer by reprogramming and insertion of gene mutation

2017 - 2020 Development of a novel treatment method for xerostomia by dental pulp stem cell-derived humoral factor

2018 - 2020 自己免疫性胚中心反応の分子機序の解明と新たな自己免疫疾患治療戦略

2017 - 2019 Establishment of highly metastatic mice model of oral squamous cell carcinoma

2017 - 2019 Study on the generation of oral cancer stem cell and analysis of its nature

2016 - 2019 Clarification of the mechanism of oral carcinogenesis by the defect of degradation of chromosome passenger complex protein

2016 - 2019 Analysis of autoimmunity caused by environmental factors~New pathogenesis of autoimmune disease~

2015 - 2019 環境因子を介した自己免疫疾患の病態解明

2015 - 2018 Analysis of migration factor expressed in dendritic cells during metal allergy development

2015 - 2018 Analysis of molecular mechanisms of sensitization phase to develop effective treatments against metal allergy

2015 - 2017 Explore for master regulator of EMT in oral cancer

2016 - 2017 自動組織薄切装置の開発

2015 - 2016 エストロゲン関連分子を用いたシェーグレン症候群の特異的診断法の開発

2011 - 2014 イメージング技術を用いた臓器特異的自己免疫疾患の病態解明

2010 - 2011 新規バイオマーカーを用いたシェーグレン症候群の確定診断法の開発

2009 - 2011 自己免疫疾患における標的臓器と免疫ネットワークの解明と新規治療法の開発

2009 - 2011 The analysis of Ni allergy development and the therapeutic strategy in prosthodontics

2009 - 2011 Immunotherapeutic analysis using newly established murine models for Sjogren' s syndrome

2008 - 2010 Effect of estrogen deficiency on the development of autoimmune diseases

2007 - 2008 調節性T細胞を制御する新規免疫調節機構の解明

2005 - 2008 自己免疫疾患におけるNF-kBを介したT細胞活性化機構

2005 - 2008 The role of NF-kB for T cell activation in autoimmune disease

2005 - 2008 Molecular analysis of pathogenesis on Sjogren's syndrome and its application of new diagnosis and therapy

2006 - 2007 Effect of Sex Hormone on the Development of Autoimmune Diseases

2003 - 2003 Fasリガンド分子制御によるシェーグレン症候群治療法の研究開発

2000 - 2002 自己免疫疾患におけるエストロジェンを介したアポトーシス調節機構の解析

2000 - 2001 自己免疫疾患老化モデルにおけるp16の解析

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Papers (159)：

Aya Ushio, Mami Matsuda-Lennikov, Felix Kalle-Youngoue, Akihide Shimizu, Abdalla Abdelmaksoud, Michael C Kelly, Naozumi Ishimaru, Yousuke Takahama. Functionally diverse thymic medullary epithelial cells interplay to direct central tolerance. Cell reports. 2024. 43. 4. 114072-114072
Hiroaki Tawara, Takaaki Tsunematsu, Shojiro Kitajima, Ruka Nagao, Shigefumi Matsuzawa, Kunihiro Otsuka, Aya Ushio, Naozumi Ishimaru. The noncanonical function of borealin, a component of chromosome passenger complex, promotes glycolysis via stabilization of survivin in squamous cell carcinoma cells. Biochemical and biophysical research communications. 2024. 706. 149741-149741
Daishiro Kobayashi, Masaya Deda, Junya Hayashi, Kota Hidaka, Yutaka Kohmura, Takaaki Tsunematsu, Kohei Nishino, Harunori Yoshikawa, Kento Ohkawachi, Kiyomi Nigorikawa, et al. Sulfoxide-mediated Cys-Trp-selective bioconjugation that enables protein labeling and peptide heterodimerization. 2024
Shengjian Jin, Takaaki Tsunematsu, Taigo Horiguchi, Yasuhiro Mouri, Wenhua Shao, Keiko Miyoshi, Hiroko Hagita, Motoharu Sarubo, Natsumi Fujiwara, Guangying Qi, et al. Involvement of the OTUB1-YAP1 axis in driving malignant behaviors of head and neck squamous cell carcinoma. Cancer medicine. 2023
Asuna Sugimoto, Kokoro Iwata, Rika Kurogoushi, Manami Tanaka, Yumiko Nakashima, Yoshihito Yamakawa, Atsushi Oishi, Keigo Yoshizaki, Satoshi Fukumoto, Akihito Yamamoto, et al. C-terminus of PIEZO1 governs Ca2+ influx and intracellular ERK1/2 signaling pathway in mechanotransduction. Biochemical and Biophysical Research Communications. 2023. 682. 39-45

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MISC (194)：

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Education (2)：

1994 - 1998 The University of Tokushima
1988 - 1994 The University of Tokushima Faculty of Dentistry School of Dentistry

Professional career (1)：

Ph.D. (Tokushima University)

Work history (11)：

2018/10 - 現在 The University of Tokushima
2011/05 - 現在 The University of Tokushima
2003/10 - 現在 The University of Tokushima
2017/04 - 2021/03 The University of Tokushima Faculty of Dentistry
2012/04 - 2021/03 The University of Tokushima Faculty of Dentistry

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Committee career (15)：

2023/07 - 現在 Japanese Dental Science Review Associate Editor
2022/07 - 現在 Frontiers in Immunology Associate Editor
2022/04 - 現在先端歯学国際教育研究ネットワーク議長
2020/04 - 現在日本口腔科学会理事
2019/10 - 現在日本口腔組織培養学会編集委員長

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Awards (7)：

2015/09 - 日本シェーグレン症候群学会学会賞
2011/09 - 日本歯科基礎医学会ライオン学術賞
2008/03 - 徳島大学学長特別表彰
2007/12 - 日本病理学会学術研究賞
2007/04 - 内閣府文部大臣表彰若手科学者賞

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Association Membership(s) (7)：

日本分子生物学会 , 日本歯科基礎医学会 , JAPANESE STOMATOLOGICAL SOCIETY , 日本シェーグレン症候群学会 , 日本口腔外科学会 , 日本免疫学会 , 日本病理学会

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