Rchr
J-GLOBAL ID：200901084830911593   Update date: Feb. 01, 2024

Fujii Junichi

Fujii Junichi
Affiliation and department：
Yamagata University Graduate School of Medical Science Major of Environmental Life Science Department of Biochemistry and Molecular Biology

About Yamagata University Graduate School of Medical Science Major of Environmental Life Science Department of Biochemistry and Molecular Biology


Job title： Professor
Research field  (2)： Pathobiochemistry ,  Medical biochemistry
Research keywords  (3)： Redox Biology ,  Molecular Biology ,  Biochemistry
Research theme for competitive and other funds  (22)：
  • 2021 - 2022 [大阪大学蛋白質研究所共同研究員]ジペプチダーゼCNDP2による酸化ストレスを起因とする新規細胞死・フェロトーシスからの保護機構の解明
  • 2020 - 2021 [大阪大学蛋白質研究所共同研究員]ジペプチダーゼCNDP2による酸化ストレスを起因とする新規細胞死・フェロトーシスからの保護機構の解明
  • 2019 - 2021 PPAR活性化による酸化ストレス・小胞体ストレス軽減による脂肪性肝疾患の改善
  • 2018 - 2021 Verification of reduction of superoxide toxicity by nitric oxide (NO) synthase and exogenous NO
  • 2019 - 2020 [大阪大学蛋白質研究所共同研究員]ジペプチダーゼCNDP2による酸化ストレスを起因とする新規細胞死・フェロトーシスからの 保護機構の解明
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Papers (129)：
  • Sho Kobayashi, Takujiro Homma, Junichi Fujii. Nitric oxide produced by NOS2 copes with the cytotoxic effects of superoxide in macrophages. Biochemistry and biophysics reports. 2021. 26. 100942-100942
  • Takujiro Homma, Sho Kobayashi, Hideyo Sato, Junichi Fujii. Superoxide produced by mitochondrial complex III plays a pivotal role in the execution of ferroptosis induced by cysteine starvation. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2021. 700. 108775
  • Naoki Ishii, Takujiro Homma, Yuji Takeda, Naing Ye Aung, Ken-Ichi Yamada, Satoshi Miyata, Hironobu Asao, Mitsunori Yamakawa, Junichi Fujii. Developmental retardation in neonates of aldehyde reductase (AKR1A)-deficient mice is associated with low ascorbic acid and high corticosterone levels. The Journal of nutritional biochemistry. 2021. 91. 108604-108604
  • Sho Kobayashi, Yumi Harada, Takujiro Homma, Chikako Yokoyama, Junichi Fujii. Characterization of a rat monoclonal antibody raised against ferroptotic cells. JOURNAL OF IMMUNOLOGICAL METHODS. 2021. 489. 112912
  • Takujiro Homma, Yuji Takeda, Tomoyuki Nakano, Shinya Akatsuka, Daisuke Kinoshita, Toshihiro Kurahashi, Shinichi Saitoh, Ken-Ichi Yamada, Satoshi Miyata, Hironobu Asao, et al. Defective biosynthesis of ascorbic acid in Sod1-deficient mice results in lethal damage to lung tissue. Free radical biology & medicine. 2021. 162. 255-265
ｍore...
MISC (109)：
  • Junichi Fujii, Takujiro Homma, Sho Kobayashi, Prashant Warang, Manisha Madkaikar, Malay B Mukherjee. Erythrocytes as a preferential target of oxidative stress in blood. Free radical research. 2021. 55. 5. 562-580
  • Junichi Fujii. Ascorbate is a multifunctional micronutrient whose synthesis is lacking in primates. Journal of Clinical Biochemistry and Nutrition. 2021
  • Takujiro Homma, Junichi Fujii. Emerging connections between oxidative stress, defective proteolysis, and metabolic diseases. Free radical research. 2020. 54. 11-12. 931-946
  • Ferroptosis caused by cysteine insufficiency and oxidative insult. 2019
  • Sho Kobayashi, Shinji Hamashima, Takujiro Homma, Junichi Fujii, Hideyo Sato. Macrophages from xCT-deficient mice survive under low cysteine/glutathione redox conditions with high oxidative stress. FREE RADICAL BIOLOGY AND MEDICINE. 2017. 108. S52-S52
ｍore...
Books (30)：
  • Ferroptosis in Health and Disease
    Springer Nature 2019
  • Glutathione and related compounds produced by the glutathione-synthesizing pathway
    Nova Science Publisher Inc 2019
  • Oxidative stress and dysfunction of the intracellular proteolytic machinery: a pathological hallmark of nonalcoholic fatty liver disease
    Elsevier 2019
  • ベインズ・ドミニチャク生化学
    エルゼビア・ジャパン 2018 ISBN:9784621301692
  • Superoxide Dismutase (SOD): Sources, Therapeutic Uses and Health Benefits." (Nancy H. Phillips, ed.)
    Nova Science Publishers, Inc 2016
ｍore...
Lectures and oral presentations  (46)：
  • マクロファージNOS2の生成するNOはスーパーオキシドの毒性消去に働く
    (第73回日本酸化ストレス学会・第20回日本NO学会 合同学術集会)
  • アスコルビン酸は遊離鉄の毒性を抑制することによりアセトアミノフェン肝障害を軽減する
    (第73回日本酸化ストレス学会・第20回日本NO学会 合同学術集会)
  • グルタチオン合成阻害環境下における鉄硫黄クラスター形成反応のフェロトーシス感受性への関与
    (第73回日本酸化ストレス学会・第20回日本NO学会 合同学術集会)
  • フェロトーシス細胞を認識するラットモノクローナル抗体の作製とその性質
    (第93回日本生化学会大会)
  • Prevention of diethylnitrosamine-induced hepatic injury and carcinogenesis in mice by vitamin C
    (8th International Translational Cancer Research Conference:Role of Inflammation and Immune System for Cancer Prevention and Treatment)
ｍore...
Works (3)：
  • Involvement of Glycation in Alzheimer Disease
    1998 - 2000
  • Mechanism of FACS onset by SOD1 mutation
    1997 - 2000
  • Roles of Redox System in Spermatogenesis
    1999 -
Education (5)：
  • - 1988 Osaka University Graduate School, Division of Medicine
  • - 1988 Osaka University Graduate School, Division of Medicine
  • - 1984 Shizuoka University Graduate School, Division of Bioresearch
  • - 1982 Shizuoka University Faculty of Science
  • - 1982 Shizuoka University Faculty of Science
Work history (12)：
  • 1999/07 - 現在 Yamagata University Graduate School of Medical Science Major of Environmental Life Science Department of Biochemistry and Molecular Biology Professor
  • 1996 - 1999 Osaka University
  • 1996 - 1999 Osaka University, Associate Professor
  • 1993 - 1996 Osaka University
  • 1993 - 1996 Assistant Professor Osaka University
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Committee career (11)：
  • 2008 - 現在 日本酸化ストレス学会 理事
  • 2001 - 現在 日本酸化ストレス学会 評議員
  • 2000 - 現在 日本生化学会 評議員
  • 2000 - 現在 日本NO学会 評議員
  • 2021/05 - 2021/05 日本酸化ストレス学会 第74回日本酸化ストレス学会学術集会 会長
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Awards (1)：
  • 2020/10 - 日本酸化ストレス学会 2020年日本酸化ストレス学会学会賞
Association Membership(s) (17)：
日本酸化ストレス学会 ,  日本癌学会 ,  日本分子生物学会 ,  日本生化学会 ,  日本NO学会 ,  Society for Free Radical Research Japan ,  Society for Free Radical Biology and Medicine& ,  Society for the Study of Reproduction ,  ˇ ,  Japanese Society of Lipid Peroxide and Free Radical Research ,  Societies for Free Radical Research ,  NO Society of Japan ,  American Society for Biochemistry and Molecular Biology ,  Japanese Cancer Association ,  Japanese Molecular Biological Society ,  Japanese Biophysical Society ,  Japanese Biochemical Society
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